The podcast also features Loretta Nastoupil, MD, Southwest Oncology, Durango, CO, Lorenzo Falchi, MD, Memorial Sloan Kettering Cancer Center, New York, NY, and Jason Westin, MD, FACP, The University of Texas MD Anderson Cancer Center, Houston, TX, who discuss the expanding role of T-cell engagers in follicular lymphoma and large B-cell lymphoma, including mosunetuzumab-based combinations and the growing number of frontline bispecific antibody trials in diffuse large B-cell lymphoma.

Pieter Sonneveld, MD, PhD, Erasmus MC, Rotterdam, The Netherlands, reviews evolving frontline treatment strategies, including quadruplet regimens, combination maintenance, and the growing role of sustained MRD negativity. Rakesh Popat, MBBS, MRCP, FRCPath, PhD, University College London Hospitals, London, UK, discusses BCMA-targeted therapies, including findings from the DREAMM-6 (NCT03544281) and REALiTEC-2 (NCT06285318) studies evaluating belantamab mafodotin and teclistamab in relapsed/refractory multiple myeloma. Finally, Nikhil Munshi, MD, Dana-Farber Cancer Institute, Boston, MA, explores evolving concepts of cure and the role of sustained MRD negativity in defining long-term remission in multiple myeloma.

The discussion highlights efficacy and safety outcomes, as well as key challenges in clinical practice, including rapid manufacturing, the role of bridging therapy, toxicity management, and optimizing patient selection. The panel also reflects on the importance of interpreting CAR T-cell trial results within the context of differing study designs and inclusion criteria.

Rabi Hanna, MD, Cleveland Clinic, Cleveland, OH, outlines key considerations for selecting patients with SCD and thalassemia for gene therapy, discusses strategies to optimize the treatment pathway from stem cell mobilization to long-term follow-up, and reviews results from the RUBY trial (NCT04853576) of gene editing therapy in severe SCD. Zachary Crees, MD, Washington University School of Medicine, St. Louis, MO, also highlights emerging mobilization approaches, including motixafortide-based strategies to improve stem cell collection for gene therapy.

Michael Wang, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, outlines the importance of frontline treatment in achieving long-term disease control. You will also hear from David Lewis, MBChB, PhD, FRCPath, Plymouth University, Plymouth, UK, Tycel Phillips, MD, City of Hope, Duarte, CA, and Krish Patel, MD, Sarah Cannon Research Institute, Nashville, TN, who share perspectives on patient selection for therapy, biological risk factors, and how treatment decisions differ between academic and community settings.

Experts discuss the growing importance of donor germline genetics, updated guidance for Hodgkin lymphoma transplantation, the shifting role of CAR T‑cell therapy in non‑Hodgkin lymphoma, and how measurable residual disease (MRD) is shaping transplant decisions and post‑transplant care.

Overall, the episode highlights how these developments are improving personalization and outcomes in haemopoietic stem cell transplantation.

The panel explores the evolving classification of myeloid neoplasms, including the shift from morphology to molecular genetics, key differences between the WHO and ICC systems, and areas of ongoing debate such as MDS, AML, and overlap syndromes. They also discuss the process of harmonising these frameworks, the clinical implications for diagnosis, trial design, and patient care, and how CAM recommendations are expected to inform a future unified WHO classification.

Ciara Freeman, MD, PhD, Moffitt Cancer Center, Tampa, FL, examines multimodal AI for predicting CAR T-cell outcomes, while Zinaida Good, PhD, Stanford University, Stanford, CA, and Andrea Schmidts, MD, Technical University of Munich, Munich, Germany, explore AI applications in CAR T-cell design. Gianluca Asti, MSc, Humanitas Clinical and Research Center, IRCCS, Rozzano, Italy, discusses federated learning for data sharing, and Amin Turki, MD, PhD, Ruhr-University Hospital Bochum and University Hospital Essen, Essen, Germany, highlights challenges in real-world AI implementation.

Amin Turki, MD, PhD, Ruhr-University Hospital Bochum and University Hospital Essen, Essen, Germany, highlights the integration of MRD into risk stratification, while Wendy Stock, MD, University of Chicago Medical Center, Chicago, IL, reviews MRD detection methods, emerging technologies, and practical implementation in ALL.

First, Erik Aerts, RN, University of Zurich, Zurich, Switzerland, will walk through the CAR T-cell process from a nursing perspective, and Mairéad Ní Chonghaile, RGN, BNS, MSc, St James’s Hospital, Dublin, Ireland, will emphasize the importance of a true collaborative approach to care in the CAR-T process and discuss how to appropriately address fears or misconceptions patients may have. You will then hear from Thomas Jezequel, MSc, Nantes University Hospital, Nantes, France, who will comment on the role of social media in a patient’s CAR T-cell therapy journey and share messages for young nurses in the cellular therapy space. Finally, Jemma Stewart, nurse educator, and Ella Weisser, clinical nurse specialist, Peter MacCallum Cancer Centre, Melbourne, Australia, will provide insight into the recommended frequency of Immune Effector Cell-Associated Encephalopathy (ICE) assessment in patients receiving CAR-T.

First, you will hear updates in mantle cell lymphoma (MCL) trials from Michael Wang, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Austin Kim, MD, Dana-Farber Cancer Institute, Boston, MA, and Tycel Phillips, MD, City of Hope, Duarte, CA. Following this, Chan Cheah, MBBS, FRACP, FRCPA, DMSc, Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia, and Jorge Castillo, MD, Dana-Farber Cancer Institute, Boston, MA, share BTKi trial updates in Waldenström’s macroglobulinemia (WM). Finally, Lorenzo Falchi, MD, Memorial Sloan Kettering Cancer Center, New York, NY, discusses the preliminary results of the MITHIC-FL2 trial (NCT05389293) investigating mosunetuzumab plus zanubrutinib in newly diagnosed high-burden follicular lymphoma (FL), and Jason Westin, MD, FACP, The University of Texas MD Anderson Cancer Center, Houston, TX, presents the primary analysis of the Smart Stop trial (NCT04978584), which evaluated a four-drug combination in newly diagnosed diffuse large B-cell lymphoma (DLBCL).

Vaishali Sanchorawala, MD, Boston University School of Medicine, Boston, MA, presents Phase II AQUARIUS trial (NCT05250973) data evaluating daratumumab-VCd dosing in newly diagnosed disease and shares Phase I trail (NCT06158854) results of the BCMA x CD3 bispecific antibody etentamig in relapsed or refractory AL amyloidosis. Heather Landau, MD, Memorial Sloan Kettering Cancer Center, New York, NY, reviews early results from the NEXICART-2 trial (NCT06097832) of the BCMA-directed CAR T-cell therapy NXC-201. Andrew Staron, MD, Boston Medical Center, Boston, MA, discusses the prognostic significance of sustained MRD negativity, while Matthew Rees, MD, St. Vincent’s Hospital, Melbourne, Australia, presents real-world data on BCMA-directed CAR T-cell and bispecific therapies in systemic AL amyloidosis.

Alexander Perl, MD, University of Pennsylvania, Philadelphia, PA, reviews the Phase I/II VICEROY study (NCT05520567) of venetoclax, azacitidine, and gilteritinib in newly diagnosed FLT3-mutated AML ineligible for intensive therapy. Naval Daver, MD, MD Anderson Cancer Center, Houston, TX, presents a Phase Ib/II trial (NCT04086264) of pivekimab sunirine plus azacitidine and venetoclax in unfit newly diagnosed AML. Wei-Ying Jen, MA, BM BCh, M Med, MRCP, FRCPath, shares results of the Phase II SAVE study (NCT05360160) exploring an all-oral revumenib, decitabine/cedazuridine, and venetoclax regimen, while Mohammad Maher Abdul-Hay, MD, NYU Langone Health, New York City, NY, discusses early data from the Phase I trial (NCT05143996) of the FLT3 x CD3 bispecific CLN-049 in relapsed or refractory AML.

In DLBCL, Matthew Matasar, MD, Memorial Sloan Kettering Cancer Center, New York, NY, reviews the Phase III OLYMPIA-3 trial (NCT06091865), Jason Westin, MD, MD Anderson Cancer Center, Houston, TX, discusses the Smart Stop study (NCT04978584), and Umberto Vitolo, MD, University of Turin, Italy, with Lorenzo Falchi, covers fixed-duration epcoritamab from the EPCORE DLBCL-3 (NCT05660967) and EPCORE NHL-2 (NCT04663347) trials. Saurabh Dahiya, MD, shares early CAR T-cell data with KITE-753 and KITE-363, Michael Wang, MD, presents Phase I/II sonrotoclax results in MCL (NCT05471843), and Nirav Shah, MD, reviews Phase Ia/b bexobrutideg data in Waldenström’s macroglobulinemia (NCT05131022).

Updates on CAR T-cell therapies are given by Shambavi Richard, MD, Mount Sinai, New York City, NY, Krina Patel, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Samir Parekh, MD, Icahn School of Medicine at Mount Sinai, New York City, NY.

Finally, Salomon Manier, MD, PhD, Lille Hospital University, Lille, France, Dickran Kazandjian, MD, University of Miami Sylvester Comprehensive Cancer Center, Miami, FL, Shahzad Raza, MD, Cleveland Clinic, Cleveland, OH, Luciano Costa, MD, PhD, UAB School of Medicine, Birmingham, AL, and Amrita Krishnan, MD, City of Hope, Duarte, CA, discuss T-cell engaging antibodies.

Carsten Niemann, MD, PhD, Copenhagen University Hospital, Copenhagen, Denmark, shares long-term follow-up results from the GAIA/CLL13 (NCT02950051) trial. Paolo Ghia, MD, Vita-Salute San Raffaele University, Milan, Italy, shares insights into the Phase III ​BELLWAVE-010 study (NCT05947851), followed by Jennifer Woyach, MD, The Ohio State University, Columbus, OH, who discusses Phase I results (NCT04775745) of a novel BTK inhibitor rocbrutinib.

Finally, Chan Cheah, MBBS, FRACP, FRCPA, DMSc, Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia, discusses the CaDAnCe-104 trial (NCT06634589) of the BTK degrader BGB-16673, and Barbara Eichhorst, MD, University Hospital Cologne, Cologne, Germany, shares two-year follow-up results from the EPCORE CLL-1 trial (NCT04623541) of epcoritamab monotherapy in Richter’s transformation.

First, in an interview with Anand Patel, MD, University of Chicago Medical Center, Chicago, IL, you will hear about the diagnosis, risk stratification, and therapeutic strategies being explored for patients with MPN-AP/BP. Dr Patel will also comment on the role and timing of allogeneic stem cell transplantation (alloSCT) in this patient population.

Following this, experts Adam Mead, MA, BM, BCh, MRCP, FRCPath, PhD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, Charlotte Brierley, MA, BM BCh, MRCP, DPhil, FRCPath, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, and Juan Carlos Hernández-Boluda, MD, PhD, Hospital Clinic of Valencia, Valencia, Spain, will discuss the challenges of managing MPN-AP/BP, highlighting the need for biomarkers to identify patients at risk of aggressive disease progression. 

The discussion features insights from Ty Simpson, BN, MNP, Alfred Health, Melbourne, Australia, who is a CAR-T nurse practitioner, and Frederick Vonberg, MD, University College London Hospitals NHS Foundation Trust, London, UK, who is a neurologist with a primary research interest in the neurotoxic effects of CAR T-cell therapy. This is followed by Angela Halley, MBBS, BSc, MSc, FRCP, Royal Marsden Hospital, London, UK, who is a consultant in palliative medicine with an interest in developing early integrated palliative care in hematology, including patients undergoing CAR-T treatment and stem cell transplant.

The experts focus on the impact of MYD88 and TP53 alterations, current treatment approaches including the use of BTK inhibitors (BTKis), and strategies for patients who discontinue BTKis. They then go on to discuss clinical trial advances, including the BRAWM trial (NCT04624906) and BTK degraders.

Following this, Alexander Lyon, MA, BM, BCh, PhD, FRCP, FHFA, Royal Brompton Hospital, London, UK, discusses cardiovascular health in patients with MPNs, and Adrián Mosquera Orgueira, MD, PhD, Santiago Clinic Hospital CHUS, Santiago, Spain, provides insight into the application of artificial intelligence (AI) in the MDS/MPN setting.

Joining the discussion are leading experts George Vassiliou, MBBS, PhD, The University of Cambridge, Cambridge, UK, Sanam Loghavi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Mrinal Patnaik, MBBS, Mayo Clinic, Rochester, MN, Susan Slager, PhD, Mayo Clinic, Rochester, MN, and Anton Langerak, PhD, Erasmus MC, Rotterdam, The Netherlands. Together, they delve into recent advances in our understanding of CHIP and CCUS, touch on monoclonal B-cell lymphocytosis as another precursor condition, and share their insights on the potential value of early intervention in these pre-malignant states.

The conversation covers early clinical signs that clinicians often overlook, key differences in presentation between subtypes, recommendations for initial diagnostic work-up, and the barriers that often delay timely diagnosis.

First, Jens Panse, MD, Aachen University Hospital, Aachen, Germany, Richard Kelly, MBChB, PhD, St James’s University Hospital, Leeds, UK, and Benjamin Chin-Yee, MD, MA, FRCPC, Western University, London, Canada, provide insight into challenging situations in the current era of PNH treatment, including switching from anti-C5 to proximal complement inhibition, discontinuing anticoagulation, and the management of pregnant patients with PNH. Following this, Austin Kulasekararaj, MBBS, MD, MRCP, FRCPath, King’s College Hospital NHS Foundation Trust, London, UK, discusses the role of ravulizumab in this disease, and Dr Kelly and Catherine Flynn, MD, St James’s Hospital, Dublin, Ireland, outline findings from the COMMODORE 1 and 2 trials. Finally, Jeff Szer, MBBS, FRACP, Peter MacCallum Cancer Centre, Melbourne, Australia, comments on the clinical problem of thrombosis in patients with PNH, highlighting how this complication can be prevented.

Dr Collins discusses the significant shifts in treatment approaches for patients with advanced-stage classical Hodgkin lymphoma over the past decade. He also explores the excitement around newer regimens, including nivolumab-AVD, BV-AVD, and more. To conclude, Dr Collins shares his approach to treating patients with relapsed disease, drawing focus on the role of autologous stem cell transplantation. 

Michael Hudecek, MD, University of Würzburg, Würzburg, Germany, then provides insight into his keynote talk on accelerating CAR T-cell therapeutics with small molecules and CRISPR 2.0 gene editing. This is followed by Krish Patel, MD, Sarah Cannon Research Institute, Nashville, TN, Tara Graff, DO, MS, Mission Cancer and Blood, Des Moines, IA, and Caron Jacobson, MD, Dana-Farber Cancer Institute, Boston, MA, who share their perspectives on how to improve access and delivery of T-cell engaging therapies in the community.

First, you will hear from Rafael Fonseca, MD, Mayo Clinic, Phoenix, AZ, Ola Landgren, MD, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, Thomas Martin, MD, University of California San Francisco, San Francisco, CA, and Adriana Rossi, MD, Mount Sinai, New York City, NY, who share updates with the use of several agents in multiple myeloma. Damian Green, MD, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, and Rachid Baz, MD, Moffitt Cancer Center, Tampa, FL, will then discuss practical considerations when using T-cell therapies, including managing adverse events and improving access.

Tune in as experts Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, and Arnon Nagler, MD, Chaim Sheba Medical Center, Tel-Aviv, Israel, provide insights into current treatment approaches for acute and chronic GvHD, discussing the advent of new therapies. Following this, you’ll hear about cytomegalovirus (CMV) management from Per Ljungman, MD, PhD, Karolinska Institute, Stockholm, Sweden, and human herpesvirus 6 (HHV-6) diagnosis from Eleftheria Kampouri, MD, University of Lausanne, Lausanne, Switzerland, and Raffaella Greco, MD, PhD, San Raffaele Hospital, Milan, Italy.

Finally, Manuela Spadea, MD, University of Turin, Turin, Italy, comments on ushering in the era of the hematologist-AI alliance, and Adrián Mosquera-Orgueira, MD, PhD, Santiago Clinic Hospital CHUS, Santiago, Spain, highlights the potential for harnessing machine learning to predict post-SCT outcomes in patients with myelofibrosis (MF).

Stay tuned to learn more about these promising approaches from experts Chan Cheah, MBBS, FRACP, FRCPA, DMSc, Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia, Armin Ghobadi, MD, Washington University School of Medicine, St. Louis, MO, Evandro Bezerra, MD, The Ohio State University Comprehensive Cancer Center, Columbus, OH, Nirav Shah, MD, Medical College of Wisconsin, Milwaukee, WI, Manali Kamdar, MD, University of Colorado Cancer Center, Denver, CO, and Valentín Ortiz-Maldonado, MD, Hospital Clinic Barcelona, Barcelona, Spain.

The experts discuss key trials in this space, including venetoclax combined with intensive induction chemotherapy, a Phase II study comparing midostaurin with gilteritinib in FLT3-mutated AML (NCT03836209), and the combination of ziftomenib with intensive chemotherapy. They also examine the role of CPX-351 in induction therapy and its potential combination with gemtuzumab ozogamicin.

In this podcast, you will hear from Krish Patel, MD, Sarah Cannon Cancer Institute, Nashville, TN, Yucai Wang, MD, PhD, Mayo Clinic, Rochester, MN, Julie Vose, MD, University of Nebraska Medical Center, Omaha, NE, Adrian Minson, MBBS, Peter MacCallum Cancer Centre and Royal Melbourne Hospital, Melbourne, Australia, and David Lewis, MD, Plymouth University, Plymouth, UK. The experts cover a variety of topics, exploring the role of BTK inhibitors in R/R MCL, promising combinations being explored, and strategies to overcome resistance.

Featuring experts Karthik Ramasamy, MBBS, MRCP, FRCPath, PhD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, Tarek Mouhieddine, MD, Mount Sinai Medical Center, New York City, NY, Mateo Mejia Saldarriaga, MD, Weill Cornell Medicine, New York, NY, Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, Joseph Mikhael, MD, MeD, FRCPC, FACP, Translational Genomics Research Institute (TGen), Phoenix, AZ, & International Myeloma Foundation, Studio City, CA, Ola Landgren, MD, PhD, Sylvester Comprehensive Cancer Center & University of Miami, Miami, FL, P. Joy Ho, MBBS, DPhil, FRACP, FRCPA, FFSc(RCPA), Royal Prince Alfred Hospital & University of Sydney, Sydney, Australia, Enrique Ocio, MD, PhD, Marquis of Valdecilla University Hospital, Santander, Spain, and Joselle Cook, MBBS, Mayo Clinic, Rochester, MN.

First, you will hear from Valentín Ortiz-Maldonado, MD, Hospital Clinic Barcelona, Barcelona, Spain, who shares the results of the pivotal CART19-BE-02 trial (NCT04778579), a multicenter study investigating varnimcabtagene autoleucel (var-cel) in adult patients with relapsed/refractory (R/R) B-cell ALL (B-ALL). Following this, Pere Barba, MD, PhD, Vall d’Hebron University Hospital, Barcelona, Spain, and Jae Park, MD, Memorial Sloan Kettering Cancer Center, New York, NY, provide valuable insight into findings from the FELIX trial (NCT04404660), the results of which led to the FDA approval of obecabtagene autoleucel (obe-cel) for adult patients with R/R B-ALL in November 2024. Next, Ibrahim Muhsen, MD, Baylor University Medical Center, Dallas, TX, shares the findings of a retrospective analysis evaluating the efficacy and safety of brexucabtagene autoleucel (brexu-cel) in older patients with R/R B-ALL. Finally, you will hear some updates of trials assessing novel CAR-T approaches in ALL from Armin Ghobadi, MD, Washington University School of Medicine, St. Louis, MO, and Evandro Bezerra, MD, The Ohio State University Comprehensive Cancer Center, Columbus, OH.

First, Sophia Delicou, MD, Hippokration General Hospital, Athens, Greece, will provide an update on the HIBISCUS (NCT04624659) trial of etavopivat in SCD, and Rabi Hanna, MD, Cleveland Clinic, Cleveland, OH, will present updated results of the RUBY (NCT04853576) trial investigating reni-cel in severe SCD. This will be followed by an update of a trial being conducted in patients with transfusion-dependent thalassemia, the ENERGIZE-T study (NCT04770779), from Maria Domenica Cappellini, MD, University of Milan, Milan, Italy. Finally, you will hear the results of the explorer7 trial (NCT04083781) in hemophilia A and B from Amy Shapiro, MD, Indiana University Hemophilia Center, Indianapolis, IN.

The discussion covers updates on smoldering myeloma, including the practice-changing results of the AQUILA (NCT03301220) study, as well as the latest advances in bispecific antibodies for relapsed/refractory multiple myeloma. The experts also highlight exciting research to watch for in 2025. Finally, they provide guidance on the use of measurable residual disease (MRD) and address the ongoing challenge of treating high-risk multiple myeloma.

You will hear insights into novel approaches to frontline chemotherapy and BCL2 inhibition from experts Ioannis Mantzaris, MD, Montefiore Medical Center/Albert Einstein College of Medicine, New York City, NY, Tapan Kadia, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Chong Chyn Chua, MBBS, FRACP, FRCPA, The Alfred Hospital and Monash University, Melbourne, Australia. 

Eunice Wang, MD, Roswell Park Comprehensive Cancer Center, Buffalo, NY, Emma Searle, MBChB, MA, MRCP, FRCPath, PhD, The Christie NHS Foundation Trust, Manchester, UK, Joshua Zeidner, MD, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, and Amer Zeidan, MBBS, MHS, Yale University and Yale Cancer Center, New Haven, CT, will then go on to share updates on the use of menin inhibitors in relapsed/refractory (AML).

This will be followed by Mark Levis, MD, PhD, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, and Nicholas Short, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, who discuss the management of FLT3-ITD+ AML.

First, you will hear key trial updates in myelofibrosis (MF) from Andrew Kuykendall, MD, Moffitt Cancer Center, Tampa, FL, Lucia Masarova, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Francesco Passamonti, MD, University of Milan, Milan, Italy. Following this, Marina Kremyanskaya, MD, PhD, Icahn School of Medicine at Mount Sinai, New York, NY, will present initial results from the Phase I/II SANRECO trial (NCT05499013) evaluating divesiran in patients with polycythemia vera (PV). Firas El Chaer, MD, University of Virginia, Charlottesville, VA, and Claire Harrison, MD, FRCP, FRCPath, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, will then give updates on trials exploring novel approaches for patients with relapsed/refractory (R/R) myelofibrosis. Finally, you will hear an update on the BOREAS trial (NCT03662126) from Prithviraj Bose, MD, The University of Texas MD Anderson Cancer Center, Houston, TX.

First, you will hear from Gilles Salles, MD, PhD, Memorial Sloan Kettering Cancer Center, New York, NY, Catherine Diefenbach, MD, NYU Langone, New York, NY, and Jia Ruan, MD, PhD, Weill Cornell Medical College, New York City, NY, who discuss novel combinations being explored in the frontline setting for diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). Sattva Neelapu, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Paolo Strati, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Nirav Niranjan Shah, MD, Medical College of Wisconsin, Milwaukee, WI, will then give updates on the use of CAR T-cells in the relapsed/refractory (R/R) setting for NHL, including follicular lymphoma (FL) and DLBCL. This will be followed by Catherine Diefenbach, MD, NYU Langone, New York, NY, and Taylor Brooks, MD, Cleveland Clinic, Cleveland, OH, who discuss the use of bispecific antibodies, and Julio Chavez, MD, Moffitt Cancer Center, Tampa, FL, who shares data on CELMoDs under investigation for the treatment of FL and DLBCL.

You will hear insights into managing anemia in lower-risk MDS (LR-MDS) from Sophie Park, MD, CHU Grenoble Alpes, Grenoble, France, Esther Oliva, MD, Grande Ospedale Metropolitano Bianchi Melacrino Morelli, Reggio Calabria, Italy, and Uwe Platzbecker, MD, University of Leipzig, Leipzig, Germany. They share data from the EPO-Pretar trial (NCT03223961), which is investigating early versus late onset of epoetin alfa treatment, an analysis of patient-reported outcomes in the COMMANDS trial (NCT03682536), and the effect of prior therapies on the activity of imetelstat in the IMerge trial (NCT02598661).

Andrius Žučenka, MD, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania, and Marina Konopleva, MD, PhD, Albert Einstein College of Medicine, New York City, NY, then go on to discuss novel approaches to managing higher-risk MDS (HR-MDS), including an individualized allogeneic stem cell transplantation (alloSCT) approach and novel non-transplant treatment approaches.

You will hear from experts Jeff Sharman, MD, Willamette Valley Cancer Institute, Eugene, OR, Jennifer Brown, MD, PhD, Dana-Farber Cancer Institute, Boston, MA, Alexey Danilov, MD, PhD, City of Hope, Duarte, CA, Nirav Niranjan Shah, MD, Medical College of Wisconsin, Milwaukee, WI, and Chan Cheah, MBBS, FRACP, FRCPA, DMSc, Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia. They discuss key updates on the use of BTK inhibitors in CLL, including the BRUIN CLL-321 (NCT04666038) and AMPLIFY (NCT03836261) trials, as well as the BTK degraders NX-2127 and NX-5948. They then go on to speak about novel approaches being explored, including treatment with the bispecific antibody epcoritamab in the EPCORE-CLL1 (NCT04623541) trial, and the use of sonrotoclax in the BGB-11417-101 (NCT04277637) trial. 

In this podcast episode, you will hear updates on menin inhibitors in AML from the 6th International Workshop on Acute Leukemias (iwAL), which took place in Phoenix, AZ. Experts Joshua Zeidner, MD, UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, and Eunice Wang, MD, Roswell Park Comprehensive Cancer Center, Buffalo, NY, delve into current data on the four menin inhibitors being investigated in AML. They then go on to discuss the development of resistance to this drug class and the potential value of these agents in the post-transplant setting. 

You will also hear from Stephen Ansell, MD, PhD, Mayo Clinic, Rochester, MN, Marion Subklewe, MD, Ludwig-Maximilians-University of Munich, Munich, Germany, Martin Hutchings, MD, PhD, Copenhagen University Hospital, Copenhagen, Denmark, and Krish Patel, MD, Swedish Cancer Institute, Seattle, WA, who share insights into the use of bispecific antibodies in the treatment of NHL. Their discussion focuses on comparisons between CAR-T and bispecifics and the unique challenges of using bispecific antibodies, including mitigating toxicities. They also mention exciting combination approaches with antibody-drug conjugates and co-stimulatory agents.

This episode focuses on the role of artificial intelligence (AI) in personalizing blood cancer care. Carsten Niemann, MD, PhD, Copenhagen University Hospital, Copenhagen, Denmark, discusses the value of AI in hematological oncology and how it is currently used in the clinic. He then shares details of a treatment infection model for chronic lymphocytic leukemia (CLL) that has been deployed in his institution. Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone, New York City, NY, delves into the role of AI in the classification of multiple myeloma and the prediction of patients who will need transplantation. He also touches on the use of AI to better understand genomic data.

The focus of this episode is pediatric acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). You will hear from Michele Redell, MD, Texas Children’s Cancer Center, Baylor College of Medicine, Houston, TX, who shares insights into the Pediatric Acute Leukemia (PedAL) Screening Trial and challenges that remain in the treatment of AML. Mark Litzow, MD, Mayo Clinic, Rochester, MN, discusses a study investigating drug responses in children compared to adults. Christina Peters, MD, St. Anna Children’s Hospital, Vienna, Austria, speaks on the FORUM trial (NCT01949129) and CAR-T therapy for pediatric patients. 

Today's episode focuses on the psychosocial impacts of living with blood cancer. First, you will hear from Lorna Warwick, BA, Lymphoma Coalition, Toronto, Canada, who shares the work of the Lymphoma Coalition Global Patient Survey. Next, you will hear insights from Surabhi Chaturvedi, MBACP, King’s College Hospital NHS Foundation Trust, London, UK, who is a senior psychotherapist in hematological oncology. Finally, Charlie Craddock, CBE, FRCP, FRCPath, University of Birmingham, Birmingham, UK, will discuss the psychosocial impacts of transplantation in acute myeloid leukemia (AML). 

This episode focuses on global perspectives of blood cancers and addresses the disparities that exist in awareness, diagnosis, and treatment. First, Lalit Kumar, MD, MBBS, Artemis Hospital, New Delhi, India, discusses challenges that exist in the management of blood cancers in India, and programs that are in place to address these. Joseph Mikhael, MD, MEd, FRCPC, FACP, Translational Genomics Research Institute (TGen), Phoenix, AZ, then goes on to address racial disparities in the treatment of multiple myeloma in America. Amrutha Sridhar, MBBS, University College London Hospitals, London, UK, discusses socioeconomic and racial disparities in myeloma trial recruitment, followed by Brian Koffman, MDCM (retired), MS Ed, CLL Society, Inc., Chula Vista, CA, who shares insights into a survey investigating global disparities in access to treatment and resources for patients with chronic lymphocytic leukemia in low-income countries.

In this podcast, experts Andrew Kuykendall, MD, Moffitt Cancer Center, Tampa, FL; Lucia Masarova, MD, The University of Texas MD Anderson Cancer Center, Houston, TX; and Kristen Pettit, MD, University of Michigan, Ann Arbor, MI, share insights into the management of PV and ET. They focus on treating the adolescent and young adult (AYA) population, defining goals when treating patients, and the feasibility of assessing long-term outcomes in clinical trials. Additionally, they emphasize collaborative research approaches and explore the potential for early interventions at the stage of clonal hematopoiesis in AYA patients.

You hear from experts Omolade Awodu, MBChB, MD, FMCPath, University of Benin, Benin City, Nigeria, who discusses key hemophilia clinical trials in 2024, Radek Kaczmarek, PhD, Indiana University School of Medicine, Indianapolis, IN, who gives an overview of gene therapies for hemophilia, and Matteo Luciani, MD, Bambino Gesù Children’s Hospital, Rome, Italy, who shares insights into the remaining challenges for patients with hemophilia.

This podcast episode features experts Andrew Wei, MBBS, PhD, Alfred Hospital and Monash University, Melbourne, Australia, Aditi Shastri, MD, Montefiore Medical Center, Bronx, NY, Uwe Platzbecker, MD, University of Leipzig, Leipzig, Germany, and Amer Zeidan, MBBS, Yale University and Yale Cancer Center, New Haven, CT. They discuss the role of inflammation and immune interventions from the 2nd International Workshop on Myelodysplastic Syndromes and Myeloproliferative Neoplasms (iwMDS) 2024, held in Boston, MA. They focus on the targeting of STAT and IRAK4, the pivotal Phase III STIMULUS-MDS2 trial (NCT04266301) of sabatolimab, and lessons that can be learned from clinical trial failures. 

The experts share key trial updates, including the Phase I/II RUBY trial (NCT04853576) of renizgamglogene autogedtemcel (reni-cel) for SCD, and the Phase III ENERGIZE trial (NCT04770779), investigating the safety and efficacy of mitapivat in non-transfusion-dependent (NTD) alpha- or beta-thalassemia. They also speak on unmet needs and challenges with gene therapies for these patients.

This week’s podcast features a discussion from the International Workshop on Myelodysplastic Syndromes & Myeloproliferative Neoplasms (iwMDS 2024) held in Boston, MA. You will hear from Naveen Pemmaraju, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Abdulraheem Yacoub, MD, The University of Kansas, Westwood, KS, Aaron Gerds, MD, MS, Cleveland Clinic, Cleveland, OH, and Claire Harrison, MD, FRCP, FRCPath, Guy’s & St Thomas’ NHS Foundation Trust, London, UK, who discuss unmet treatment needs in MF. They focus on the management of prefibrotic MF and thrombocytopenia, novel agents beyond the JAK/STAT pathway, and endpoints for clinical trials. 

Tune in as Manali Kamdar, MD, University of Colorado Cancer Center, Denver, CO, Tycel Phillips, MD, City of Hope, Duarte, CA, Chan Cheah, MBBS, Linear Clinical Research and Sir Charles Gairdner Hospital, Perth, Australia, and Alexey Danilov, MD, PhD, City of Hope, Duarte, CA, share insights into the impact of BTK inhibitors on patient outcomes, the nuances between covalent and non-covalent BTK inhibitors, and further discuss ongoing trials evaluating these agents.

You will hear from experts Amer Zeidan, MBBS, Yale University and Yale Cancer Center, New Haven, CT, Rena Buckstein, MD, FRCPC, Odette Cancer Research Program, Sunnybrook Research Institute, Toronto, Canada, Guillermo Garcia-Manero, MD, University of Texas MD Anderson Cancer Center, Houston, TX, and Andrew Brunner, MD, Massachusetts General Hospital, Boston, MA. They discuss important considerations for physicians when treating LR-MDS, providing valuable insights into some of the common pitfalls in clinical practice which may lead to suboptimal responses in patients.

You will hear from Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, who discusses updated data from the MagnetisMM-3 trial (NCT04649359) of elranatamab and real-world findings from a French compassionate use program using this agent. Rahul Banerjee, MD, FACP, Fred Hutchinson Cancer Center, Seattle, WA, provides insights into the real-world step-up dosing of teclistamab to mitigate toxicities. Finally, Sundar Jagannath, MD, Tisch Cancer Institute at Mount Sinai, New York, NY, discusses a matched adjusted indirect comparison (MAIC) of the novel bispecific linvoseltamab with teclistamab, and the sequencing of bispecific antibodies with CAR T-cells. 

You will hear from experts Toby Eyre, MBChB (Hons), DipMedEd, MRCP (UK), FRCPath (UK), MD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, and Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, who will discuss combinations of BTK and BCL2 inhibitors, the efficacy of BTK degraders in CLL, and the role of epcoritamab in the treatment of RT. 

Join leading experts Mario Nuvolone, MD, PhD, University of Pavia, Pavia, Italy, Vaishali Sanchorawala, MD, Boston University School of Medicine, Boston, MA, Patrick Hagen, MD, Loyola University Medical Center, Chicago, IL, and Efstathios Kastritis, MD, University of Athens School of Medicine, Athens, Greece, as they discuss the critical importance of early diagnosis in AL amyloidosis, exciting clinical trials in progress, patient selection for stem cell transplantation (SCT), and more.

In this podcast, experts Amer Zeidan, MBBS, Yale Cancer Center, New Haven, CT, Valeria Santini, MD, University of Florence, Florence, Italy, and Courtney DiNardo, MD, MSCE, The University of Texas MD Anderson Cancer Center, Houston, TX, delve into the historical context of treatment developments, sharing insights on the emergence of novel agents like luspatercept and imetelstat. They explore the current paradigm for managing LR-MDS, including the strategic use of hypomethylating agents (HMAs) and other innovative therapies. The experts also touch on the future of clinical trials and the importance of early intervention in improving quality of life (QoL) and survival for patients.

In this podcast, Naveen Pemmaraju, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Marina Konopleva, MD, PhD, Albert Einstein College of Medicine, New York City, NY, and Emanuele Angelucci, MD, Armando Businco Oncology Hospital, Sardegna, Italy, discuss the treatment and monitoring of BPDCN. They highlight the role of CD123-targeting agents, including tagraxofusp, the involvement of the central nervous system (CNS), and share strategies for treating adolescents and young adults (AYAs) with this aggressive disease.

This podcast features experts Anna Sureda, MD, PhD, Catalan Institute of Oncology, Duran I Reynals Hospital, Barcelona, Spain, who discusses the future of CAR-T therapy and the risk of secondary malignancies, and Manali Kamdar, MD, University of Colorado Cancer Center, Denver, CO, who gives an overview of the currently approved CAR-T products and bispecific antibodies in large B-cell lymphoma, and the optimal sequencing of these agents. 

In this episode, Ola Landgren, MD, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, Suzanne Lentzsch, MD, PhD, Columbia University, New York, NY, Thomas Martin, MD, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, and Suzanne Trudel, MSc, MD, Princess Margaret Cancer Centre, Toronto, Canada, discuss the use of various agents in myeloma, including the suitability of bisphosphonates to treat bone disease, and updates with the use of isatuximab and belantamab mafodotin. The experts also share their thoughts on the benefits of using measurable residual disease (MRD) as a surrogate endpoint in clinical trials.

Today's VJHemOnc podcast features experts Mary Frances McMullin, MD, Queen’s University, Belfast, UK, who discusses strategies to manage anemia in MF, and Claire Harrison, MD, FRCP, FRCPath, Guy’s & St Thomas’ NHS Foundation Trust, London, UK, who gives a comprehensive overview of promising MPN clinical trials in the UK, and further discusses how to approach young patients with MPNs.

Tune in as experts Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, Ernst Holler, MD, University Hospital Regensburg, Regensburg, Germany, and Florent Malard, MD, PhD, Saint-Antoine Hospital and Sorbonne University, Paris, France, provide insights into current and emerging treatment approaches for acute and chronic GvHD, discussing the advent of new therapies. Following this, you'll learn about the importance of the gut microbiome in the severity of GvHD and how this can be manipulated to improve patient outcomes.

In this podcast, Daniel Lenihan, MD, FACC, Saint Francis Healthcare System, Cape Girardeau, MO, Raul Cordoba, MD, PhD, University Hospital Fundación Jiménez Díaz, Madrid, Spain, and Iskra Pusic, MD, MSCI, Washington University School of Medicine, St. Louis, MO, unravel the critical relevance of cardio-oncology, stressing the significance of multidisciplinary teams (MDTs) and the application of the ESC 2022 guidelines. Discussing their experiences from different healthcare institutions across the globe, the experts underscore the importance of cooperation between cardiologists and hematologists as they navigate difficult medical decisions for patients with specific complications.

In this week's podcast, you will hear from Shaji Kumar, MD, Mayo Clinic, Rochester, MN, Elena Zamagni, MD, PhD, University of Bologna, Bologna, Italy, and Bruno Paiva, PhD, University of Navarra, Pamplona, Spain, who discuss novel technologies being explored to risk stratify individuals with SMM and MGUS. Following this, Irene Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA, Kwee Yong, PhD, FRCP, FRCPath, University College London, London, UK, and Omar Nadeem, MD, Dana-Farber Cancer Institute, Boston, MA, discuss the possibility of early interception in SMM, highlighting ongoing trials in the field. This episode is part of our podcast series from the 2024 Intercepting Blood Cancers (IBC) Workshop, which was held in Lisbon, Portugal.

In this podcast, Uma Borate, MD, The Ohio State University, Columbus, OH, Kelly Bolton, MD, PhD, Washington University School of Medicine, St. Louis, MO, and Eric Padron, MD, Moffitt Cancer Center, Tampa, FL, discuss knowledge gaps in the field, share insights from ongoing trials, and further emphasize the importance of multidisciplinary teamwork in managing CHIP and CCUS. This episode is part of our podcast series from the 2024 Intercepting Blood Cancers (IBC) Workshop, which was held in Lisbon, Portugal.

In this podcast, Stephen Ansell, MD, PhD, Mayo Clinic, Rochester, MN, Paolo Ghia, MD, Vita-Salute San Raffaele University, Milan, Italy, Andrew Rawstron, PhD, Leeds Teaching Hospitals NHS Trust, Leeds, UK, and Anton Langerak, MD, PhD, Erasmus Medical Center and University, Rotterdam, The Netherlands, discuss the biology, classification, and possible interventions for MBL. This discussion took place at the 2024 Intercepting Blood Cancers Workshop in Lisbon, Portugal. 

In this podcast, Maria-Victoria Mateos, MD, PhD, University of Salamanca, Salamanca, Spain, Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD, University College London Hospitals, London, UK, and Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, discuss the significance of CAR-T therapy in myeloma, how to select patients for CAR-T therapy, the evolving role of autologous stem cell transplantation (autoSCT), and more. 

In this podcast, you will hear from Morie Gertz, MD, MACP, Mayo Clinic, Rochester, MN, Ashutosh Wechalekar, MBBS, MD, FRCP, FRCPath, DM, University College London Hospitals NHS Foundation Trust, London, UK, and Daniel Lenihan, MD, FACC, Saint Francis Health System, Cape Girardeau, MO, who discuss the significant role of cardio-oncology in amyloidosis, currently available therapies, diagnostic approaches being explored, and more.

In this podcast, you will hear from Ulrich Jäger, MD, Medical University of Vienna, Vienna, Austria, who discusses the importance of lymphodepletion in CAR-T therapy, Kai Rejeski, MD, Memorial Sloan Kettering Cancer Center, New York, NY, who updates us on ICAHT, and Gérard de Pouvourville, PhD, ESSEC Business School, Cergy, France, who shares his thoughts on the cost effectiveness of these agents.

In this podcast, André Baruchel, MD, PhD, Hospital Robert Debré AP-HP, Paris, France, Pere Barba, MD, PhD, Vall d’Hebron University Hospital, Barcelona, Spain, and Alex Rampotas, MD, University College London, London, UK, cover several topics, including challenges with administering CAR-T therapy in B- and T-ALL, the possibility of exploring dual-targeting of CD19 and CD22 to overcome resistance, considerations for managing patients with B-ALL prior to CAR-T therapy, and more.

In this podcast, Mark Levis, MD, PhD, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, Ghayas Issa, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Ibrahim Aldoss, MD, City of Hope, Duarte, CA, and Aaron Goldberg, MD, PhD, Memorial Sloan-Kettering Cancer Center, New York, NY, comment on the growing role of targeted agents in AML. The experts draw focus on the promise of menin inhibitors, highlighting findings from the AUGMENT-101 (NCT04065399) and KOMET-008 (NCT05735184) trials.

In this podcast, you will hear from leading experts who discuss several topics in LR-MDS and HR-MDS. Rena Buckstein, MD, FRCPC, Sunnybrook Research Institute, Toronto, Canada, and Valeria Santini, MD, University of Florence, Florence, Italy, discuss challenges in LR-MDS, including red blood cell transfusion dependence and approaching patients who fail erythropoiesis‑stimulating agents (ESAs). You will also hear from Amer Zeidan, MBBS, Yale Cancer Center, New Haven, CT, Aditi Shastri, MD, Montefiore Medical Center, Bronx, NY, and David Sallman, MD, Moffitt Cancer Center, Tampa, FL, who discuss novel targets in HR-MDS, moving past hypomethylating agents (HMAs), and ongoing trials in the field. 

In this podcast, you will hear from experts Maria Domenica Cappellini, MD, University of Milan, Milan, Italy, and Kevin Kuo, MD, MSc, FRCPC, University Health Network, Toronto, Canada, who discuss recent updates in thalassemia presented at the 2023 ASH Annual Meeting. The experts cover several topics, including the promise of novel gene therapies, the BEYOND trial (NCT03342404), and more.

In this podcast, you will hear from Naveen Pemmaraju, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Nerses Ghahramanyan, MD, Yeolyan Hematology and Oncology Center, Yerevan, Armenia, Marco Herling, MD, University of Leipzig, Leipzig, Germany, and Claudio Cerchione, MD, PhD, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST), Meldola, Italy, who discuss promising therapies emerging in the field, current challenges, and more. 

In this podcast, Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, Bruno Paiva, PhD, University of Navarra, Pamplona, Spain, and Benjamin Derman, MD, University of Chicago, Chicago, IL, discuss several interesting topics in myeloma, including the challenges associated with sequencing anti-BCMA therapies, the prognostic value of circulating tumor cells (CTCs), and the growing role of quadruplet therapies in myeloma, with updates in this space from the 2023 ASH Annual Meeting.

In this podcast, leading experts Rabi Hanna, MD, Cleveland Clinic, Cleveland, OH, and Josu de la Fuente, PhD, FRCP, FRCPI, FRCPCH, FRCPath, Imperial College London, London, UK, discuss key updates in SCD presented at the 2023 ASH Annual Meeting and Exposition. The experts cover several topics, including the pathogenesis of SCD, novel agents being explored, and the growing role of gene therapies.

In this podcast, you will hear from experts Ashutosh Wechalekar, MBBS, MD, FRCP, FRCPath, DM, University College London Hospitals NHS Foundation Trust, London, UK, and Vaishali Sanchorawala, MD, Boston University School of Medicine, Boston, MA, who discuss the latest updates in the treatment and management of AL amyloidosis at the 65th ASH Annual Meeting and Exposition.

At the 65th ASH Annual Meeting and Exposition, leading experts Ruben Mesa, MD, Levine Cancer Institute, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston Salem, NC, Claire Harrison, MD, FRCP, FRCPath, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, and Jean-Jacques Kiladjian, MD, PhD, Saint-Louis Hospital & Paris Diderot University, Paris, France, shared their key highlights in MPNs, commenting on ongoing trials and promising combinations being explored, as well as future outlooks.

In this podcast, David Maloney, MD, PhD, Fred Hutchinson Cancer Research Center, Seattle, WA, Jason Westin, MD, FACP, The University of Texas MD Anderson Cancer Center, Houston, TX, and David Miklos, MD, PhD, Stanford University, Stanford, CA, discuss the growing role of CAR-T therapy in NHL and further comment on how to expand the CAR platform in this disease setting.

Tune in as we share some key highlights from this year's meeting. In this podcast, a variety of topics are covered, including the role of continuous BTK inhibitors (BTKis) in CLL, the importance of investigating the biology of Richter's transformation (RT), and the need to address the underrepresentation of elderly patients in CLL clinical trials. You will hear from several leading experts, including Kerry Rogers, MD, Ohio State University, Columbus, OH, Brian Koffman, MDCM (retired), DCFP, FCFP, DABFP, MSEd, CLL Society, Inc., Chula Vista, CA, Raul Cordoba, MD, PhD, University Hospital Fundación Jiménez Díaz, Madrid, Spain, and Adam Kittai, MD, Ohio State University, Columbus, OH.

In this podcast, Tanya Siddiqi, MD, City of Hope, Duarte, CA, and Nirav Shah, MD, Medical College of Wisconsin, Milwaukee, WI, discuss the role of BTK inhibitors and degraders in NHL. Following this, you will hear from Martin Hutchings, MD, PhD, Copenhagen University Hospital, Copenhagen, Denmark, Marion Subklewe, MD, Ludwig-Maximilians University, Munich, Germany, Mazyar Shadman, MD, Fred Hutchinson Cancer Research Center, Seattle, WA, and Krish Patel, MD, Swedish Cancer Institute, Seattle, WA, who discuss the growing role of bispecific antibodies, including glofitamab, epcoritamab and odronextamab, in this disease setting.

In this podcast, Angela Dispenzieri, MD, Mayo Clinic, Rochester, MN, Paolo Lopedote, MD, St Elizabeth’s Medical Center, Boston, MA, Vaishali Sanchorawala, MD, Boston University School of Medicine, Boston, MA, and Efstathios Kastritis, MD, University of Athens, Athens, Greece, discuss unmet needs in AL amyloidosis, as well as novel immunotherapy strategies being explored. The experts also highlight the prevalence of clonal hematopoiesis of indeterminate potential (CHIP) in this disease setting.

In this podcast, John Gribben, MD, DSc, FRCPath, FRCP, FMedSci, Barts Cancer Institute, London, UK, Laurie Sehn, MD, University of British Columbia, Vancouver, Canada, Andrew Davies, MRCP, PhD, University of Southampton, Southampton, UK, and Sven De Vos, MD, PhD, David Geffen School of Medicine at UCLA, Los Angeles, CA, discuss novel therapies in NHL, drawing focus on the role of antibody-drug conjugates (ADCs).

In this podcast, Lucia Masarova, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Anthony Hunter, MD, Winship Cancer Institute of Emory University, Atlanta, GA, Jean-Jacques Kiladjian, MD, PhD, Saint-Louis Hospital & Paris Diderot University, Paris, France, and John Mascarenhas, MD, Mount Sinai Medical Center, New York, NY, discuss several updates in the field of MPNs. Topics covered include novel agents being explored in PV, clinical guidance for the use of JAK inhibitors in MF, and the growing role of combination approaches.

In this podcast, Stephen Ansell, MD, PhD, Mayo Clinic, Rochester, MN, Marek Trněný, MD, PhD, Charles University, Prague, Czech Republic, John Kuruvilla, MD, Princess Margaret Cancer Centre, Toronto, Canada, and Yucai Wang, MD, PhD, Mayo Clinic, Rochester, MN, share some insights into the evolving treatment landscape in mantle cell lymphoma (MCL), commenting on the changing role of transplantation and the impact of novel agents.

In this podcast, Francine Foss, MD, Yale School of Medicine, New Haven, CT, Laurence de Leval, MD, PhD, Lausanne University Hospital, Lausanne, Switzerland, Francois Lemonnier, MD, PhD, Henri Mondor University Hospital, Créteil, France, and Steven Horwitz, MD, Memorial Sloan Kettering Cancer Center, New York City, NY, discuss recent updates in the biology and treatment of T-cell lymphoma.

In this podcast, Charles Craddock, CBE, FRCP(UK), FRCPath, DPhil, University of Birmingham, Birmingham, UK, David Sallman, MD, Moffitt Cancer Center, Tampa, FL, Mark Levis, MD, PhD, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, and Nelli Bejanyan, MD, Moffitt Cancer Center, Tampa, FL, discuss the most recent updates in transplantation and immunotherapies in AML, and further comment on how to improve outcomes for patients.

In this podcast, Pallawi Torka, MD, Memorial Sloan Kettering Cancer Center, New York City, NY, and Jonathan Friedberg, MD, MMSc, University of Rochester, Rochester, NY, discuss challenges with classifying frailty in elderly patients with diffuse large B-cell lymphoma (DLBCL) and HL, as well as treatment options available to these patients.

In this podcast, you will hear from Sanam Loghavi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Rami Komrokji, MD, Moffitt Cancer Center, Tampa, FL, who discuss recent updates in the diagnosis, risk stratification and treatment of LR-MDS. This discussion was filmed at the Eleventh Annual Meeting of the Society of Hematologic Oncology (SOHO 2023) held in Houston, TX.

In this podcast, Andrew Wei, MBBS, PhD, Peter MacCallum Cancer Centre and the Royal Melbourne Hospital, Melbourne, Australia, and Sanam Loghavi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discuss the relevance of TP53 mutation in AML, highlighting prognostic approaches and therapeutic strategies for this patient population. 

In this podcast, Naval Daver, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Gail Roboz, MD, Weill Cornell Medicine, New York City, NY, Harry Erba, MD, PhD, Duke University, Durham, NC, and Jessica Altman, MD, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, discuss new treatments in AML, drawing focus on FLT3 inhibitors, novel combinations, and treating patients with relapsed disease.

In this podcast, Ravi Majeti, MD, PhD, Stanford University, Stanford, CA, Courtney DiNardo, MD, MSCE, The University of Texas MD Anderson Cancer Center, Houston, TX, Uma Borate, MBBS, The Ohio State University Comprehensive Cancer Center, Columbus, OH, and Koichi Takahashi, MD, PhD, The University of Texas MD Anderson Cancer Center, Houston, TX, discuss clonal hematopoiesis (CH) in AML, early detection and intervention, and potential therapeutic strategies.

In this podcast, you will hear from Meral Beksac, MD, Ankara University, Ankara, Turkey, Luciano Costa, MD, PhD, UAB School of Medicine, Birmingham, AL, and Bruno Paiva, PhD, University of Navarra, Pamplona, Spain, who discuss the exciting potential applications of MRD in multiple myeloma and share insights from recent clinical trials.

While both CAR-T cells and bispecific antibodies have their benefits, there are several factors to consider when evaluating their curative potential in R/R DLBCL. In this podcast, you will hear from Manali Kamdar, MD, University of Colorado, Aurora, CO, Anna Sureda, MD, PhD, Catalan Institute of Oncology, Duran I Reynals Hospital, Barcelona, Spain, and Gloria Iacoboni, MD, Vall d’Hebron Institute of Oncology, Barcelona, Spain, who share some insights into the value of CAR-T cells and bispecifics in R/R DLBCL, the benefits and drawbacks of these agents, and further comment on their efficacy and curative potential.

In this podcast, you will hear from Moshe Mittelman, MD, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, and Klaus Metzeler, MD, University of Leipzig Medical Center, Leipzig, Germany, who discuss approaches used to identify patients with pre-MDS states, the importance of early intervention, and challenges with distinguishing these conditions. The experts also highlight strategies that may be used to improve diagnosis, and further discuss treatment approaches being explored for these individuals.

In this podcast, Anand Patel, MD, University of Chicago, Chicago, IL, Andrew Kuykendall, MD, Moffitt Cancer Center, Tampa, FL, and Jan Philipp Bewersdorf, MD, Memorial Sloan Kettering Cancer Center, New York City, NY, discuss the mutational landscape of MPN-AP, and further highlight challenges with treating patients. The experts also comment on novel therapeutic strategies being explored in this space.

In this podcast, experts Salomon Manier, MD, PhD, Lille University Hospital, Lille, France, Surbhi Sidana, MD, Stanford University, Stanford, CA, and Hermann Einsele, MD, FRCP, University of Würzburg, Würzburg, Germany, share some interesting insights into the optimal sequencing of bispecific antibodies and CAR-T cells in myeloma, highlighting data from recent clinical trials.

In this podcast, you will hear from Edward Cliff, MPH, MBBS, Brigham and Women’s Hospital, Boston, MA, and Natacha Bolaños, Lymphoma Coalition Europe, Madrid, Spain, who discuss two major barriers to CAR-T therapy: the high cost of CAR-T cells and the need to improve access to these agents.

In this podcast, you will hear from Ruben Mesa, MD, Levine Cancer Institute, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston Salem, NC, Lucia Masarova, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Jeanne Palmer, MD, Mayo Clinic, Phoenix, AZ, who discuss the importance of understanding and addressing QoL in patients with MPNs, and further highlight strategies to improve symptom management.

In this podcast, experts Meral Beksac, MD, Ankara University, Ankara, Turkey, Shaji Kumar, MD, Mayo Clinic, Rochester, MN, and Efstathios Kastritis, MD, University of Athens School of Medicine, Athens, Greece, discuss recent updates in the treatment and management of amyloidosis, and further highlight the importance of the MDT in this disease.

In this podcast, you will hear from Michiel Coppens, MD, PhD, Amsterdam UMC, Amsterdam, The Netherlands, and Johannes Oldenburg, MD, University Clinic Bonn, Bonn, Germany, who discuss the current standard of care in hemophilia and share some insights into the value of gene therapies. 

In this podcast, you will hear from Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, and Othman-Al Sawaf, MD, University Hospital of Cologne, Cologne, Germany, who discuss the latest updates with the use of BTK inhibitors in CLL. Topics addressed include the management of double-refractory patients, the efficacy and toxicity of covalent and non-covalent BTK inhibitors, the sequencing of these agents, and more. 

In this podcast, you will hear from Jesús San Miguel, MD, University of Navarra, Pamplona, Spain, and Enrique Ocio, MD, PhD, Marqués de Valdecilla University Hospital, Santander, Spain, who share some updates from the CARTITUDE-4 and CARTITUDE-1 trials (NCT04181827; NCT03548207), and further comment on current and emerging uses of measurable residual disease (MRD) in clinical practice.

In this podcast, you will hear from Gloria Iacoboni, MD, Vall d’Hebron University Hospital, Barcelona, Spain, and Paolo Strati, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, who share some insights into recent advances in CAR-T therapy and bispecific antibodies in the treatment of LBCL. Topics covered include the sequencing of these agents, bridging therapies, and managing toxicities and cytopenias after CAR-T therapy. 

In this podcast, you will hear from John Gribben, MD, DSc, FRCP, FRCPath, FMed Sci, Barts Cancer Institute, London, UK, Joseph Melenhorst, PhD, Cleveland Clinic, Cleveland, OH, and Tanya Siddiqi, MD, City of Hope, Duarte, CA, who discuss challenges with implementing CAR-T therapy in CLL, ongoing clinical trials, and research exploring combination approaches with CAR-T cells and Bruton's tyrosine kinase (BTK) inhibitors.

In this podcast, you will hear from Amer Zeidan, MBBS, Yale University and Yale Cancer Center, New Haven, CT, and Valeria Santini, MD, University of Florence, Florence, Italy, as they discuss the management of anemia in LR-MDS and strategies to overcome treatment failure in HR-MDS. This discussion was filmed at the 17th International Congress on Myelodysplastic Syndromes (MDS) 2023, held in Marseille, France.

In this podcast, you will hear from David Sallman, MD, Moffitt Cancer Center, Tampa, FL, Marion Subklewe, MD, Ludwig-Maximilians University, Munich, Germany, and Roman Shapiro, MD, Dana-Farber Cancer Institute, Boston, MA, who discuss major challenges with CAR-T therapy in AML, strategies to improve outcomes for patients, and more. 

In this podcast, you will hear from leading experts Bijal Shah, MD, Moffitt Cancer Center, Tampa, FL, Rebecca Gardner, MD, Seattle Children's Hospital, Seattle, WA, Claire Roddie, MD, PhD, University College London Hospitals NHS Foundation Trust, London, UK, and Nirav Shah, MD, Medical College of Wisconsin, Milwaukee, WI, who discuss the latest updates with CAR-T therapy in ALL. The experts share some insights into challenges with implementing CAR-T therapy in this disease, and further explain strategies to improve the efficacy of these agents. 

In this podcast, you will hear from Loretta Nastoupil, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Tycel Phillips, MD, City of Hope, Duarte, CA, and Mazyar Shadman, MD, Fred Hutchinson Cancer Research Center, Seattle, WA, who share some updates on CAR-T therapy in lymphoma, and further discuss where bispecific antibodies may fit in the treatment landscape.

In this podcast, Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone, New York City, NY, Pieter Sonneveld, MD, PhD, Erasmus University, Rotterdam, The Netherlands, and Sagar Lonial, MD, Winship Cancer Institute of Emory University, Atlanta, GA, discuss the possibility of reaching a cure in multiple myeloma, and further highlight concepts that need to be addressed to deliver this to patients.

In this podcast, you will hear from Ruben Mesa, Levine Cancer Institute, Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, NC, Jeanne Palmer, MD, Mayo Clinic, Phoenix, AZ, Claire Harrison, MD, FRCP, FRCPath, Guy’s & St Thomas’ NHS Foundation Trust, London, UK, and Haris Ali, MD, City of Hope, Duarte, CA, who discuss the current role of alloSCT in MPNs and how this may change with novel agents.

In this podcast, Irene Ghobrial, MD, Dana-Farber Cancer Institute, Boston, MA, Paola Neri, MD, PhD, University of Calgary, Calgary, AB, Canada, Lawrence Boise, PhD, Winship Cancer Institute of Emory University, Atlanta, GA, and Charlotte Pawlyn, BA, MBBChir, MRCP, PhD, FRCPath, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK, discuss the tumor microenvironment, the immune microenvironment, and mechanisms of resistance to agents including IMiDs, bispecifics and CAR-T cells.

In this podcast, Leif Bergsagel, MD, Mayo Clinic, Phoenix, AZ, Francesco Maura, MD, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, Jill Corre, PharmD, PhD, The Cancer University Institute of Toulouse Oncopole (IUCT), Toulouse, France, and Niels Weinhold, PhD, University Hospital Heidelberg, Heidelberg, Germany, discuss the genomics of high-risk multiple myeloma and smoldering myeloma. Topics covered include the importance of next-generation sequencing (NGS), the role of del(17p) and TP53 mutations, and more.

In this podcast, you will hear from Charles Craddock, CBE, FRCP(UK), FRCPath, DPhil, University of Birmingham, Birmingham, UK, and Christopher Hourigan, MD, DPhil, National Institutes of Health, Bethesda, MD, who discuss the important role of transplantation in AML, the value of pre-transplant MRD, and more. This discussion was filmed at the 18th International Symposium on Acute Leukemias (ISALXVIII), held in Munich, Germany. 

In this podcast, you will hear from Anna Sureda, MD, PhD, Catalan Institute of Oncology, Duran I Reynals Hospital, Barcelona, Spain, who shares some insights into the current role of chemotherapy in HL and various subtypes of NHL, and further explains how novel therapies, including CAR-T cells and antibodies, are changing the treatment landscape of these diseases.

In this podcast, experts Amer Zeidan, MBBS, Yale University and Yale Cancer Center, New Haven, CT, Sanam Loghavi, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Rami Komrokji, MD, and Somedeb Ball, MD, Moffitt Cancer Center, Tampa, FL, discuss the latest updates in the classification of MDS and share some insights into how these may impact clinical practice.

In this podcast, you will hear from experts Eleni Gavriilaki, MD, PhD, G. Papanikolaou Hospital, Thessaloniki, Greece, Kevin McNerney, MD, MSc, Johns Hopkins All Children’s Hospital, St. Petersburg, FL, and Andriyana Bankova, MD, University Hospital Zurich, Zurich, Switzerland, who share some insights into the treatment and management of these common toxicities.

In this podcast, experts Arnon Nagler, MD, Chaim Sheba Medical Center, Tel-Aviv, Israel, Maksim Mamonkin, PhD, Baylor College of Medicine, Houston, TX, Nicholas Short, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Ryan Cassaday, MD, University of Washington, Seattle, WA, share some insights into the growing role of immunotherapy in ALL. Topics covered include the value of novel agents, targeting CD7 in T-ALL, and the possibility of moving away from stem cell transplantation (SCT). 

In this podcast, you will hear from John Gribben, MD, DSc, FRCP, FRCPath, FMed Sci, Barts Cancer Institute, London, UK, Marco Ruella, MD, University of Pennsylvania, Philadelphia, PA, and Adam Kittai, MD, Ohio State University, Columbus, OH, who share some insights into the current status of CAR-T therapy in CLL. The experts discuss challenges with developing efficacious CAR-T products for CLL, the possibility of combining CAR-T cells with ibrutinib, and further comment on the latest advances in CAR-T therapy for Richter's transformation.

In this podcast, you will hear from experts Charles Craddock, CBE, FRCP (UK), FRCPath, DPhil, University of Birmingham, Birmingham, UK, Shernan Holtan, MD, University of Minnesota, Minneapolis, MN, Anna Sureda, MD, PhD, Catalan Institute of Oncology, Duran I Reynals Hospital, Barcelona, Spain, and Christopher Kanakry, MD, National Cancer Institute, Bethesda, MD, who discuss the importance of addressing post-transplant complications, and further highlight current approaches to GvHD prophylaxis and treatment.

In this podcast, you will hear from experts Francesco Maura, MD, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, Mattia D’Agostino, MD, University of Turin, Turin, Italy, and Karthik Ramasamy, MBBS, MRCP, FRCPath, PhD, Oxford University Hospitals NHS Foundation Trust, Oxford, UK, who discuss the prognostic role of MRD in multiple myeloma, the value of MRD-guided treatment, and clinical trials in this space. 

In this podcast, you will hear from experts David Sallman, MD, Moffit Cancer Center, Tampa, FL, Eric Padron, MD, Moffitt Cancer Center, Tampa, FL, and Jacqueline Garcia, MD, Dana-Farber Cancer Institute, Boston, MA, who discuss novel immune therapies being explored in MDS, emphasizing the challenges and opportunities for CAR-T therapy in this space.

In this podcast, you will hear from experts Michael Dickinson, MBBS, DMedSc, FRACP, FRACPA, Peter MacCallum Cancer Centre, Melbourne, Australia, and Tycel Phillips, MD, City of Hope, Duarte, CA, who share their highlights in non-Hodgkin lymphoma (NHL). Topics covered include updates from the TRIANGLE trial (NCT02858258), the changing role of transplantation, and novel immunotherapies in the field.

In this podcast, you will hear from experts Aaron Gerds, MD, Cleveland Clinic, Cleveland, OH, and Lucia Masarova, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, who discuss key updates in myeloproliferative neoplasms (MPNs) presented at this year's meeting. Topics covered include updates from the MOMENTUM trial (NCT04173494), the importance of combination approaches, and novel agents being explored, including calreticulin (CALR)-targeting antibodies. 

In this podcast, you will hear from experts Kate Cwynarski, FRCP, FRCPath, PhD, University College Hospitals London NHS Foundation Trust, London, UK, and Swaminathan Iyer, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, who discuss key updates in T-cell lymphoma. Topics covered include the importance of real-world data (RWD) in this space, addressing CNS relapse, and novel treatment approaches being explored.

In this exclusive podcast, you will hear from Naval Daver, MD, University of Texas MD Anderson Cancer Center, Houston, TX, Uwe Platzbecker, MD, University of Leipzig, Leipzig, Germany, and David Sallman, MD, Moffit Cancer Center, Tampa, FL, who discuss the important role of CD47 in MDS, agents under investigation, and other targets of interest in this space. 

In this podcast, you will hear from Matthew Davids, MD, Dana-Farber Cancer Institute, Boston, MA, and Lindsey Roeker, MD, Memorial Sloan Kettering Cancer Center, New York, NY, who discuss recent updates in chronic lymphocytic leukemia (CLL). The experts comment on the role of doublet and triplet therapies in CLL, clinical trial updates, and further highlight the impact of novel Bruton's tyrosine kinase (BTK) inhibitors in this space.

In this podcast, Yi Lin, MD, PhD, Mayo Clinic, Rochester, MN, and Krina Patel, MD, Msc, The University of Texas MD Anderson Cancer Center, Houston, TX, share key updates in multiple myeloma presented at this year’s meeting. The experts comment on real-world experiences with access to CAR-T therapy, the importance of optimizing the sequencing of therapies, ongoing clinical trials in high-risk disease, and more.

In this podcast, David Sallman, MD, Moffitt Cancer Center, Tampa, FL, and Andrew Brunner, MD, Massachusetts General Hospital, Boston, MA, discuss key updates in myelodysplastic syndromes (MDS) presented at this year's meeting. Topics covered include the treatment of lower-risk and higher-risk disease, novel classification systems, clinical trial updates, and treatment options after failure to hypomethylating agents (HMAs).

In this podcast, Laurie Sehn, MD, BC Cancer Agency, Vancouver, Canada, Carmelo Carlo Stella, MD, PhD, Humanitas Cancer Center, IRCCS Humanitas Research Hospital, Milan Italy, and David Straus, MD, Memorial Sloan Kettering Cancer Center, New York, NY, share some insights into novel therapies in non-Hodgkin lymphoma (NHL), drawing focus on the role of antibody-drug conjugates (ADCs). The experts discuss updates on the use of several ADCs, including brentuximab vedotin, loncastuximab tesirine, polatuzumab vedotin, and camidanlumab tesirine, and where these agents fit in the treatment landscape.

In this podcast, Naval Daver, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, Paresh Vyas, MRCP, FRCP, FRCPath, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK, Alexander Perl, MD, University of Pennsylvania, Philadelphia, PA, and Carsten Müller-Tidow, MD, University Hospital Heidelberg, Heidelberg, Germany, discuss mechanisms of resistance to targeted therapies in AML, and the role of epigenetics. 

In this podcast, you will hear from Lydia Scarfò, MD, Vita-Salute San Raffaele University & IRCCS San Raffaele Scientific Institute, Milan, Italy, Nitin Jain, MD, University of Texas MD Anderson Cancer Center, Houston, TX, Richard Rosenquist, MD, PhD, Karolinska Institute, Stockholm, Sweden, Florence Cymbalista, MD, Hôpital Avicenne, Bobigny, France, and Paolo Ghia, MD, Università Vita-Salute San Raffaele, Milan, Italy, who discuss the importance of genomic testing in CLL and how this impacts treatment decisions.

In this podcast, Catherine Bollard, MBChB, MD, FRACP, FRCPA, Children's National Health System, Washington, DC, Jeremy Abramson, MD, Massachusetts General Hospital Cancer Center, Boston, MA, Barbara Savoldo, MD, PhD, UNC School of Medicine, Chapel Hill, NC, and Maksim Mamonkin, PhD, Baylor College of Medicine, Houston, TX, discuss the latest updates in T-cell therapies for the treatment of NHL, commenting on real-world data on CD19-directed CAR-Ts, and exploring the potential of other T-cell therapies including CD30, CD20, and CD5-directed CAR-Ts in T-cell lymphomas. 

In this podcast, leading experts Nitin Jain, MD, University of Texas MD Anderson Cancer Center, Houston, TX, and Catherine Coombs, MD, UC Irvine Health, Orange, CA, discuss key updates in CLL, including the changing role of chemotherapy in the era of novel agents, the promise of next-generation BTK inhibitors, and more. This discussion took place at the 10th Annual Meeting of the Society of Hematologic Oncology (SOHO), which was held in Houston, TX, from September 28-October 1.

In this podcast, you will hear from Bijal Shah, MD, H. Lee Moffitt Cancer Center, Tampa, FL, Sabina Chiaretti, MD, PhD, Sapienza University of Rome, Rome, Italy, Elias Jabbour, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Nicolas Boissel, MD, PhD, Saint-Louis Hospital, Paris, France, who discuss the evolving treatment landscape in ALL, debating the role of immunotherapies, including antibody-drug conjugates (ADCs) and CAR-T cells.

This podcast episode focuses on the optimal management of relapsed/refractory (R/R) follicular lymphoma (FL), where you will hear from Laura Pasqualucci, MD, Columbia University Irving Medical Center, New York, NY, Jessica Okosun, MA, MB BChir, MRCP, FRCPath, PhD, Barts Cancer Institute, Queen Mary University of London, London, UK, and David Qualls, MD, Memorial Sloan Kettering Cancer Center, New York, NY. The experts debate on how to best treat, combine, and sequence therapies in R/R FL, and further comment on the role of epigenetic alterations in this disease. 

In this podcast, Richard Stone, MD, Dana-Farber Cancer Institute, Boston, MA, David Sallman, MD, H. Lee Moffitt Cancer Center, Tampa, FL, and Thomas Cluzeau, MD, PhD, Central University Hospital of Nice, Nice, France, discuss novel targets and combinations in AML, treatment approaches for patients with TP53-mutated disease, and more. 

In this podcast, you will hear from experts Jorge Cortes, MD, Augusta University, Augusta, GA, and Mhairi Copland, MB ChB, PhD, University of Glasgow, Glasgow, UK, who discuss the latest in chronic myeloid leukemia (CML), including treatment strategies for patients with multiple refractory disease, and novel agents in the field. The experts also comment on clinical trial updates, including data from the OPTIC trial (NCT02467270) and the ASCEMBL trial (NCT03106779).

The second session from iwNHL focused on the role of the tumor immune microenvironment in lymphoma. In this podcast, John Gribben, MD, DSc, FRCP, FRCPath, FMed Sci, Barts Cancer Institute, London, UK, Stephen Ansell, MD, PhD, Mayo Clinic, Rochester, MN, John Kuruvilla, MD, FRCPC, Princess Margaret Cancer Center, Toronto, Canada, and Gaël Roué, PhD, Josep Carreras Leukemia Research Institute, Barcelona, Spain, discuss the importance of understanding the tumor immune microenvironment in NHL. The experts outline strategies to engage the innate and adaptive anti-tumor immune response, and explain how this can be used to enhance the efficacy of immune therapies. 

In this podcast, Robin Foà, MD, Sapienza University of Rome, Rome, Italy, Rob Pieters, MD, PhD, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands, Nicholas Short, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and Nicolas Boissel, MD, PhD, Saint-Louis Hospital, Paris, France, discuss novel treatment strategies in ALL, including the role of combination approaches and antibody drug conjugates, and more.

In this podcast, you will hear from leading experts Rafael Bejar, MD, PhD, University of California San Diego, San Diego, CA, Rashmi Kanagal-Shamanna, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, and David Sallman, MD, Moffitt Cancer Center, Tampa, FL, who discuss the role of the innate immune system in MDS, and further highlight the role of chronic inflammation in this disease, as well as future therapeutic strategies. 

The first session from iwAL focused on the standard of care in AML in 2022. In this podcast, Mark Levis, MD, PhD, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, Eunice Wang, MD, Roswell Park Comprehensive Cancer Center, Buffalo, NY, Jessica Altman, MD, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, and Charles Craddock, CBE, FRCP, FRCPath, DPhil, University of Birmingham, Birmingham, UK, discuss and debate the current standard of care in AML in 2022, commenting on the role of transplantation and novel agents, as well as treatment approaches for relapsed FLT3-mutated disease.

The first session from iwNHL focused on advances in the treatment and management of T-cell lymphoma. In this podcast, Laurence de Leval, MD, PhD, Lausanne University Hospital, Lausanne, Switzerland, Steven Horwitz, MD, PhD, Memorial Sloan-Kettering Cancer Center, New York, NY, François Lemonnier, MD, Henri Mondor University Hospital, Créteil, France, and David Sibon, MD, PhD, Henri Mondor University Hospital, Créteil, France, discuss the safety and efficacy of brentuximab vedotin in enteropathy-associated T-cell lymphomas (EATL), epigenetic drugs and TRBC1-directed CAR-T therapy in T-cell lymphoma, and novel developments in the field of cutaneous T-cell lymphoma (CTCL). 

In this exclusive podcast, you will hear from experts Shaji Kumar, MD, Mayo Clinic, Rochester, MN, and Ashutosh Wechalekar, MBBS, MD, FRCP, FRCPath, DM, University College London, London, UK, as they share their highlights from this year's meeting. Topics covered in this podcast include the evolution of diagnostic approaches in light chain (AL) amyloidosis, advances in imaging techniques, and the role of hematopoietic stem cell transplantation (HSCT) in the era of daratumumab-based therapies. 

In this exclusive podcast, Charlotte Pawlyn, BA, MBBChir, MRCP, PhD, FRCPath, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK, and Rakesh Popat, BSc, MBBS, MRCP, FRCPath, PhD, University College London Hospitals NHS Foundation Trust, London, UK, hold a fascinating discussion on the management of high-risk patients, highlighting data from several UK clinical trials. The experts also discuss the prognostic value of MRD and its application in clinical practice, the management of frail patients, and further comment on the recent approval of teclistamab by the European Medicines Agency (EMA). 

In this exclusive podcast, you will hear from experts Andrew Kuykendall, MD, H. Lee Moffitt Cancer Center, Tampa, FL, and Angela Fleischman, MD, PhD, University of California Irvine, Irvine, CA, as they share some insights into disease progression in MPNs, the importance of early intervention, and future targets.

In this podcast, Amer Zeidan, MBBS, Yale School of Medicine, New Haven, CT, Rena Buckstein, MD, FRCPC, Sunnybrook Health Sciences Centre, Toronto, Canada, and Valeria Santini, MD, University of Florence, Florence, Italy, share key highlights from this year's workshop. The experts comment on the importance of improving clinical trial design and therapeutic options for patients, as well challenges in the field. 

In this podcast, Heinz Ludwig, MD, Wilhelminen Cancer Research Institute, Wilhelminenspital, Vienna, Austria, and Meral Beksac, MD, Ankara University, Ankara, Turkey, hold a fascinating discussion on identifying high-risk myeloma patients, and parameters that can be used to define high-risk disease. The experts also comment on treatment strategies for this patient population, emphasizing the promise of CAR-T therapy and bispecific antibodies. This discussion took place at the 19th International Myeloma Society (IMS) Annual Meeting held in Los Angeles, CA.

In this podcast, leading experts Hetty Carraway, MD, Cleveland Clinic, Cleveland, OH, Justin Taylor, MD, Sylvester Comprehensive Cancer Center, Miami, FL, Andrew Brunner, MD, Massachusetts General Hospital, Boston, MA, and Olatoyosi Odenike, MD, UChicago Medicine, Chicago, IL, share their thoughts on how to improve the efficiency of drug approvals in MDS. The experts cover several interesting topics, including the challenges associated with treating high-risk disease, novel targets of interest, and more. This discussion took place at the 1st International Workshop on Myelodysplastic Syndromes (iwMDS) held in Miami, FL.

In this exclusive podcast, leading experts Ruben Mesa, MD, UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, and Naveen Pemmaraju, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, share key updates in the treatment and management of essential thrombocythemia (ET), polycythemia vera (PV), and myelofibrosis (MF), and more highlights from this year's meeting.

In this exclusive podcast, you will hear from Uwe Platzbecker, MD, University of Leipzig, Leipzig, Germany, Daniel Starczynowski, PhD, Cincinnati Children’s Hospital, Cincinnati, OH, Naval Daver, MD, University of Texas MD Anderson Cancer Center, Houston, TX, and David Sallman, MD, Moffit Cancer Center, Tampa, FL, who share their thoughts on why there are fewer treatment options for MDS patients compared to other hematological malignancies, the promise of CAR-T therapy and CD47 antibodies in MDS treatment, and more. 

In this podcast, Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone Health, New York, NY, Rafael Fonseca, MD, Mayo Clinic, Phoenix, AZ, Leif Bergsagel, Mayo Clinic, Phoenix, AZ, and Keith Stewart, MB, ChB, Princess Margaret Cancer Centre, Toronto, Canada, share their highlights from day two of the Myeloma 2022 meeting. The experts cover several topics, including the biology behind BCL2 inhibitors, T-cell exhaustion and its role in resistance to immunotherapies, and more.

In this exclusive podcast, you will hear from experts John Gribben, MD, DSc, FRCP, FRCPath, FMed Sci, Barts Cancer Institute, London, UK, Saar Gill, MD, PhD, University of Pennsylvania, Philadelphia, PA, and Mazyar Shadman, MD, MPH, Fred Hutchinson Cancer Research Center, Seattle, WA, who discuss the challenges of implementing CAR-T therapy in CLL, the promise of these agents, and more. This discussion took place at the 4th International Workshop on CAR-T (iwCAR-T) meeting held in Tampa, FL.

In this podcast, you will hear from experts Mrinal Patnaik, MBBS, Mayo Clinic, Rochester, MN, Zhuoer Xie, MD, MSCR, Moffitt Cancer Center, Tampa, FL, and Eric Padron, MD, Moffitt Cancer Center, Tampa, FL, who discuss clonal hematopoiesis and the impact of mutations in MDS, as well as the importance of better understanding precursor states. This discussion took place at the 1st International Workshop on Myelodysplastic Syndromes (iwMDS) held in Miami, FL.

In this exclusive podcast, leading experts Hermann Einsele, MD, FRCP, University of Würzburg, Würzburg, Germany, Nina Shah, MD, University of California, San Francisco, CA, and Thomas Martin, MD, University of California, San Francisco, CA, discuss the current challenges and future applications of T-cell engagers in multiple myeloma, the role of maintenance and transplantation, and more. This discussion took place at The International Workshop on Myeloma 2022, held in Scottsdale, AZ.

In this exclusive podcast, you will hear from leading experts Uwe Platzbecker, MD, University of Leipzig, Leipzig, Germany, Naval Daver, MD, University of Texas MD Anderson Cancer Center, Houston, TX, Andrew Brunner, MD, Massachusetts General Hospital, Boston, MA, and Justin Taylor, MD, Sylvester Comprehensive Cancer Center, Miami, FL, who discuss the current state of the art in high-risk MDS, unmet needs, and future therapeutic approaches. 

The MDS Podcasts on VJHemOnc are supported by Gilead Oncology. Gilead Oncology has no influence over the production of the content. 

In this exclusive podcast, Kedar Kirtane, MD, Laura Oswald, PhD, and Heather Jim, PhD, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, discuss the importance of investigating patient-reported outcomes in CAR-T recipients. This discussion took place at the 4th International Workshop on CAR-T (iwCAR-T) meeting held in Tampa, FL.

In this exclusive podcast, Yi Lin, MD, PhD, Mayo Clinic, Rochester, MN, Suzanne Trudel, MD, MSc, Princess Margaret Cancer Centre, Toronto, Canada, Frederick Locke, MD, H. Lee Moffitt Cancer Center, Tampa, FL, and Krina Patel, MD, MSc, The University of Texas MD Anderson Cancer Center, Houston, TX, share key updates from the lymphoma and myeloma sessions held at this year’s meeting. The experts discuss several topics, including the benefit of CAR-T in second-line diffuse large B-cell lymphoma (DLBCL), strategies to overcome the challenges of CAR-T therapy in myeloma, patient selection for CAR-T therapy, and more.

In this podcast, you will hear from leading experts John DiPersio, MD, PhD, Washington University School of Medicine, Saint Louis, MO, Saar Gill, MD, PhD, University of Pennsylvania, Philadelphia, PA, and Rizwan Romee, MD, Dana-Farber Cancer Institute, Boston, MA, who share some insights on the challenges of CAR-T therapy in AML and strategies to overcome these. The experts also discuss CAR-NK therapy, NK-cell transduction, patient response to CAR-T therapy, and more. This discussion took place at the 4th International Workshop on CAR-T (iwCAR-T) meeting held in Tampa, FL.

In this exclusive podcast, leading experts David Maloney, MD, PhD, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle, WA, Caron Jacobson, MD, MMSc, Dana-Farber Cancer Institute, Boston, MA, and Loretta Nastoupil, MD, The University of Texas MD Anderson Cancer Center, Houston, TX, discuss the current state of CAR-T therapy in lymphoma. The experts comment on moving CAR-T therapy into earlier lines of treatment, and discuss clinical trial updates, including results from the TRANSFORM study (NCT03575351) and the ZUMA-12 study (NCT03761056). This discussion took place at the 4th International Workshop on CAR-T (iwCAR-T) meeting held in Tampa, FL.

In this exclusive podcast, Mohamad Mohty, MD, PhD, Saint-Antoine Hospital, Paris, France, and Saad Usmani, MD, MBA, FACP, Memorial Sloan Kettering Cancer Center, New York, NY, discuss key advances in myeloma treatment from this year’s EHA meeting, drawing focus on the DETERMINATION trial (NCT01208662) and the promise of novel immunotherapies.

In this podcast, leading experts Rafael Bejar, MD, PhD, University of California San Diego, San Diego, CA, Aziz Nazha, MD, Amazon Web Services, Westlake, OH, Robert Hasserjian, MD, Massachusetts General Hospital, Boston, MA, and Jane Churpek, MD, MS, University of Wisconsin School of Medicine, Madison, WI, discuss updates in classification and risk stratification in MDS, including the value of the novel IPSS-M and the MDS Clinical Research Consortium Molecular Prognostic Tool. This discussion took place at the 1st International Workshop on Myelodysplastic Syndromes (iwMDS) held in Miami, FL.

In this exclusive podcast, Keith Stewart, MB, ChB, Princess Margaret Cancer Centre, Toronto, Canada, Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone, New York, NY, and Faith Davies, MBBCh, MRCP, MD, FRCPath, NYU Langone, New York, NY, share some key highlights from day one at this year's meeting. The experts talk on updates in MRD and prognosis, antibody therapy for amyloidosis, and more. 

In this exclusive podcast, you will hear from leading experts Uwe Platzbecker, MD, Leipzig University Hospital, Leipzig, Germany, Alan List, MD, Precision BioSciences, Durham, NC, David Sallman, MD, Moffitt Cancer Center, Tampa, FL, and Daniel Starczynowski, PhD, Cincinnati Children’s Hospital, Cincinnati, OH, as they discuss immune dysregulation and targeting in MDS. This discussion took place at the 1st International Workshop on Myelodysplastic Syndromes (iwMDS) held in Miami, FL. 

In this exclusive podcast, you will hear from experts Noelle Frey, MD, MSCE, University of Pennsylvania, Philadelphia, PA, Bijal Shah, MD, Moffitt Cancer Center, Tampa, FL, and Shannon Maude, MD, PhD, Children's Hospital of Philadelphia, Philadelphia, PA, who discuss the future of CAR-T therapy in ALL, highlighting the impact of the approval of tisagenlecleucel (tisa-cel) in adult patients, the promise of allogeneic products, and more. This discussion took place at the 4th International Workshop on CAR-T (iwCAR-T) meeting held in Tampa, FL.

In this exclusive podcast, leading experts Lawrence Boise, PhD, Winship Cancer Institute of Emory University, Atlanta, GA, and Paola Neri, MD, PhD, University of Calgary, Calgary, AB, Canada, discuss novel targets in multiple myeloma, including RAS and PIKfyve, and further comment on the epigenomics and epigenetics of resistance to proteasome inhibitors and IMiDs, as well as PROTAC therapy for difficult to manipulate targets.

In this exclusive podcast, leading experts Claire Harrison, MD, DM, FRCP, FRCPath, Guy’s and St Thomas’ NHS Foundation Trust, London, UK, Ruben Mesa, MD, UT Health San Antonio MD Anderson Cancer Center, San Antonio, TX, and Jean-Jacques Kiladjian, MD, PhD, Saint-Louis Hospital & Paris Diderot University, Paris, France, hold a fascinating discussion on current developments in the management and treatment of MPNs.

In this exclusive podcast, Angela Dispenzieri, MD, Mayo Clinic, Rochester, MN, shares some insights into the treatment and management of light chain (AL) amyloidosis, highlighting the importance of early diagnosis and raising awareness of this disease. Dr Dispenzieri also discusses important clinical trials, unmet needs and challenges in the field, and the promise of novel agents being evaluated for the treatment of this disease.