TheSugarScience Podcast- curating the scientific conversation in type 1 diabetes

Heard on the Street: Christopher Emfinger, PhD, University of Wisconsin-Madison

Tue, 16 Jul 2024 10:37:17 -0700

Check out “Heard on the Street” recorded during Day 1 of the Midwest Islet Club Meeting 2024. Hear from Dr. Christopher Emfinger at University of Wisconsin-Madison as he shares his poster titled "Identifying Conditional Dependence of Proteins Regulating Islet Biology with Machine Learning".

Heard on the Street: Jeong Hun Jo, PhD, Washington University in St. Louis

Mon, 15 Jul 2024 19:24:49 -0700

Check out “Heard on the Street” recorded during Day 1 of the Midwest Islet Club Meeting 2024. Hear from Dr. Jeong Hun Jo at Washington University in St. Louis as he shares his poster titled "Wnt4 controls insulin biosynthesis, processing, and secretion in pancreatic beta cells".

Heard on the Street: Christopher Acree, PhD Candidate, Vanderbilt University Medical Center

Wed, 10 Jul 2024 22:24:39 -0700

Check out “Heard on the Street” recorded during Day 1 of the Midwest Islet Club Meeting 2024. Hear from Christopher Acree at Vanderbilt University Medical Center who gave the talk "High-resolution mapping of glucose-derived 13C in pancreatic islets using MIMS-EM: Unraveling organelle interactions and metabolic flux" at the MIC 2024 meeting. He discusses some of the technology and techniques in the Rafael Arrojo e Drigo lab.

Heard on the Street: Noyonika Mukherjee, PhD, Indiana Biosciences Research Institute

Wed, 10 Jul 2024 22:02:25 -0700

Check out “Heard on the Street” recorded during Day 1 of the Midwest Islet Club Meeting 2024. Hear from Dr. Noyonika Mukherjee at Indiana Biosciences Research Institute as she shares her poster titled "RIPK1 kinase activity mediates TNFα+IFNγ-induced inflammation and β-cell cytotoxicity".

Heard on the Street: Debjyoti Kundu, PhD, Indiana Biosciences Research Institute

Wed, 10 Jul 2024 21:53:46 -0700

Check out “Heard on the Street” recorded during Day 1 of the Midwest Islet Club Meeting 2024. Hear from Dr. Debjyoti Kundu at Indiana Biosciences Research Institute's as he shares his poster titled "Pivotal role of NADH:ubiquinone oxidoreductase assembly factor 8 in beta cell stress adaptation".

Heard on the Street: Michael Kalwat, PhD, Indiana Biosciences Research Institute's Diabetes Center

Wed, 10 Jul 2024 21:44:50 -0700

Check out “Heard on the Street” recorded during Day 1 of the Midwest Islet Club Meeting 2024. Hear from Dr. Michael Kalwat at Indiana Biosciences Research Institute's Diabetes Center as he shares his poster titled "Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning".

Heard on the Street: Bart Roep, MD, Leiden University Medical Center

Mon, 26 Feb 2024 13:59:31 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Bart Roep at Leiden University Medical Center as he shares his thoughts on the key points of the nPOD meeting.

Heard on the Street: Noel Morgan, PhD, University of Exeter

Thu, 22 Feb 2024 14:50:05 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Noel Morgan at University of Exeter as he shares highlights from the meeting and talks about his current work.

Heard on the Street: Richard Oram, PhD, University of Exeter

Thu, 22 Feb 2024 14:29:06 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Richard Oram at University of Exeter as he shares highlights from the meeting.

Heard on the Street: Tim Tree, PhD, Kings College London

Thu, 22 Feb 2024 09:56:02 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Tim Tree at Kings College London as he shares key takeaways from the meeting.

Heard on the Street: Leeana Peters, PhD, University of Florida

Thu, 22 Feb 2024 09:50:15 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting poster session. Hear from Dr. Leeana Peters at University of Florida as she shares her poster with us.

Heard on the Street: Georgia Fousteri, PhD, Dompé

Wed, 21 Feb 2024 18:55:07 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Georgia Fousteri at Dompé as she shares her current role and take aways from the meeting.

Heard on the Street: Teresa Mastracci, PhD, Indiana University

Wed, 21 Feb 2024 18:43:02 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Teresa Mastracci at Indiana University as she shares her key takeaways from the meeting.

Heard on the Street: Nick Thomas, MD PhD, University of Exeter

Wed, 21 Feb 2024 18:35:48 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Nick Thomas at University of Exeter as he talks about the work he presented as well as thoughts on work presented during the meeting.

Heard on the Street: Rupangi Vasavada, PhD, City of Hope

Wed, 21 Feb 2024 18:27:17 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Rupangi Vasavada at City of Hope as she talks about a recent clinical trial grant they received for testing Denosumab.

Heard on the Street: Richard David Leslie, MD, University of London

Wed, 21 Feb 2024 18:19:59 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Richard David Leslie at University of London as he shares thoughts on the scientific meeting as well as his current work.

Heard on the Street: Yuval Dror, PhD, Hebrew University

Wed, 21 Feb 2024 18:10:59 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Yuval Dror at Hebrew University shares about their current work.

Heard on the Street: Geetha Mylvaganam, PhD, Grace Voorhees, MS, and Timothy Nelson, MS, Abata Therapeutics

Wed, 21 Feb 2024 17:43:53 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Geetha Mylvaganam, Grace Voorhees, MS, and Timothy Nelson, MS, all at Abata Therapeutics as they share takeaways and future directions from nPOD 2024.

Heard on the Street: Raghu Mirmira, MD PhD, University of Chicago

Wed, 21 Feb 2024 17:21:58 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Dr. Raghu Mirmira at University of Chicago as he shares work they presented at the meeting discussing their patent-pending nanoparticle technology targeting beta cells and thoughts on other work presented during the meeting.

Heard on the Street: Melanie Shapiro PhD, Denise Drotar PhD, Leeana Peters PhD, Victoria Kuznetsova PhD Candidate, Becca Davidson PhD, Chaitra Rao PhD, and Jacob Enriquez PhD

Wed, 21 Feb 2024 16:54:35 -0800

Check out “Heard on the Street” recorded during Day 3 of the nPOD 2024 scientific meeting. Hear from Drs. Melanie Shapiro (University of Florida), Denise Drover (University of Florida), Leeana Peters (University of Florida), Becca Davidson (University of Michigan), Chaitra Rao (Indiana University), and Jacob Enriquez (UChicago) as well as PhD Candidate Victoria Kuznetsova (UMiami) as they share exciting take aways from the meeting.

Heard on the Street: Julia Panzer, PhD, City of Hope

Tue, 20 Feb 2024 16:35:44 -0800

Check out “Heard on the Street” recorded during Day 2 of the nPOD 2024 scientific meeting. Hear from Dr. Julia Panzer at City of Hope as she shares takeaways from a recent session.

Heard on the Street: Barbara Ehall, PhD Candidate, Medical University of Graz

Tue, 20 Feb 2024 14:04:14 -0800

Check out “Heard on the Street” recorded during Day 1 of the nPOD 2024 scientific meeting. Hear from Dr. Barbara Ehall at Medical University of Graz as she shares her current work on the NOD diabetic mouse model.

Episode 190: Bruce Verchere, PhD, University of British Columbia

Fri, 22 Dec 2023 00:35:08 -0800

In this episode, Monica Westley, PhD, catches up with Bruce Verchere, PhD, the winner of the 2023 Lifetime Achievement Award in Diabetes.

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet and exchange with thought leaders in the field of type 1 diabetes. Link below to sign up for a seat in the cafe!

Heard on the Street: Vit Neuman, MD PhD, Charles University in Prague

Tue, 27 Jun 2023 17:54:15 -0700

Check out “Heard on the Street” recorded during the ADA 2023 Conference. Hear from Dr. Vit Neuman at Charles University in Prague as he shares his poster: changes in gut bacterium composition in low-carbohydrate diet in children with type 1 diabetes.

Heard on the Street: Guanlan Xu, PhD, University of Alabama

Tue, 27 Jun 2023 17:50:35 -0700

Check out “Heard on the Street” recorded during the ADA 2023 Conference. Hear from Dr. Guanlan Xu at University of Alabama as he shares his poster: Verapamil prevents decline of IGF-1 in subjects with T1D.

Heard on the Street: Caroline Miranda, PhD, University of Gothenburg

Tue, 27 Jun 2023 17:47:56 -0700

Check out “Heard on the Street” recorded during the ADA 2023 Conference. Hear from Dr. Caroline Miranda at University of Gothenburg as she shares her poster: Alpha-cell heterogeneity contributes to phasic glucagon release.

Heard on the Street: Katy Digovich, CEO, and Sapna Puri, VP and PhD, Minutia

Tue, 27 Jun 2023 17:41:39 -0700

Check out “Heard on the Street” recorded during the ADA 2023 Conference. Hear from CEO Katy Digovich and Dr. Sapna Puri both at Minutia as they share about what is going on at Minutia. Check out more about minutia: https://www.minutia.co.

Heard on the Street: Corentin Cros-Méneur, PhD, University of Michigan Medical School

Tue, 27 Jun 2023 17:29:25 -0700

Check out “Heard on the Street” recorded during the ADA 2023 Conference. Hear from Dr. Corentin Cras-Méneur at University of Michigan Medical School as he shares his poster: novel imaging platform highlights the disconnect between beta cell mass and glucose control in type 1 diabetes.

Heard on the Street: Aaron Cox, PhD, Baylor College of Medicine

Tue, 27 Jun 2023 17:22:09 -0700

Check out “Heard on the Street” recorded during the ADA 2023 Conference. Hear from Dr. Aaron Cox at Baylor College of Medicine as he shares his poster: Leptin regulates delta cell secretion of somatostatin from human mouse islets

Heard on the Street: Jason Gaglia, MD, Joslin Diabetes Center

Tue, 27 Jun 2023 17:18:12 -0700

Check out “Heard on the Street” recorded during the ADA 2023 Conference. Hear from Dr. Jason Gaglia at Joslin Diabetes Center as he shares his exciting poster: Novel autologous dendritic cell therapy AVT001 for type 1 diabetes.

Heard on the Street: Shilton Dhaver, Joslin Diabetes Center

Tue, 27 Jun 2023 16:56:06 -0700

Check out “Heard on the Street” recorded during the ADA 2023 Conference. Hear from Shilton Dhaver at Joslin Diabetes Center as he shares his poster: relationship between glycemic control and body weight in non-alcoholic fatty liver disease in patients with type 1 diabetes.

Heard on the Street: Faisal Malik, MD, T1D Exchange

Tue, 27 Jun 2023 16:51:51 -0700

Check out “Heard on the Street” recorded during the ADA 2023 Conference. Hear from Dr. Faisal Malik at T1D Exchange as he talks about initiatives of the T1D exchange and ADA's involvement.

Heard on the Street: Jessica Dunne, PhD, Novo Nordisk

Tue, 27 Jun 2023 16:45:12 -0700

Check out “Heard on the Street” recorded during the ADA 2023 Conference. Hear from Dr. Jessica Dunne the director of T1D research at Novo Nordisk as she shares her highlights of the conference and future directions of T1D research.

Heard on the Street: Elsa McCallan, PhD Candidate, and Richard Oram, PhD, University of Exeter

Thu, 22 Jun 2023 17:13:10 -0700

Check out “Heard on the Street” recorded during Day 3 of Islet Study Group 2023. Hear from Dr. Richard Oram and his graduate student Elsa McCallan from University of Exeter.

Heard on the Street: Hazem Ibrahim, PhD Researcher, University of Helsinki

Thu, 22 Jun 2023 17:09:25 -0700

Check out “Heard on the Street” recorded during Day 1 of Islet Study Group 2023. Hear from Hazem Ibrahim from University of Helsinki.

Heard on the Street: Bruno Freitas, PhD Candidate, University of British Columbia

Thu, 22 Jun 2023 17:04:36 -0700

Check out “Heard on the Street” recorded during Day 2 of Islet Study Group 2023. Hear from Bruno Freitas from University of British Columbia.

Heard on the Street: Olof Idevall-Hagren, PhD, Uppsala University

Thu, 22 Jun 2023 17:02:18 -0700

Check out “Heard on the Street” recorded during Day 3 of Islet Study Group 2023. Hear from Dr. Olof Idevall-Hagren from Uppsala University.

Heard on the Street: David Lorberbaum, PhD, University of Michigan Medical School

Thu, 22 Jun 2023 16:58:58 -0700

Check out “Heard on the Street” recorded during Day 2 of Islet Study Group 2023. Hear from Dr. David Lorberbaum from University of Michigan Medical School.

Heard on the Street: Deasung Jang, PhD Candidate, University of British Columbia

Thu, 22 Jun 2023 16:56:48 -0700

Check out “Heard on the Street” recorded during the poster session at the Islet Study Group 2023. Hear from Deasung Jang from University of British Columbia as he discusses his poster: single cell glucose-stimulated insulin secretion assay using nanowell-in-microwell plates.

Heard on the Street: Jelena Kolic, PhD, UBC

Thu, 22 Jun 2023 16:46:21 -0700

Check out “Heard on the Street” recorded during Day 2 of Islet Study Group 2023. Hear from Dr. Jelena Kolic from University of British Columbia as she speaks about her talk at the conference.

Heard on the Street: Bruce Verchere, PhD, University of British Columbia

Thu, 22 Jun 2023 16:40:51 -0700

Check out “Heard on the Street” recorded during Day 2 of Islet Study Group 2023. Hear from Dr. Bruce Verchere from University of British Columbia.

Heard on the Street: Accalia Fu, PhD, UMass Chan Medical School

Thu, 22 Jun 2023 16:37:25 -0700

Check out “Heard on the Street” recorded during Day 2 of Islet Study Group 2023. Hear from Dr. Accalia Fu from UMass Chan Medical School.

Heard on the Street: Daniel Luciano, PhD, University of British Columbia

Wed, 21 Jun 2023 17:17:19 -0700

Check out “Heard on the Street” recorded during Day 2 of Islet Study Group 2023. Hear from Dr. Dan Luciano from University of British Columbia as he discusses his lab's work and future directions.

Heard on the Street: Rana Minab, PhD Candidate, University of British Columbia

Wed, 21 Jun 2023 17:13:58 -0700

Check out “Heard on the Street” recorded during the Day 2 poster session at Islet Study Group 2023. Hear from Rana Minab from University of British Columbia as she discusses her poster: Using Fecal microbiome transplantation for type 1 diabetes therapy.

Heard on the Street: Jim Johnson, PhD, University of British Columbia

Wed, 21 Jun 2023 17:09:42 -0700

Check out “Heard on the Street” recorded during Day 2 of Islet Study Group 2023. Hear from Dr. Jim Johnson from University of British Columbia and the organizer of the conference as he discusses his thoughts on the conference thus far and the research going on his lab.

Heard on the Street: Burcak Yesildag, PhD, InSphero

Wed, 21 Jun 2023 17:03:35 -0700

Check out “Heard on the Street” recorded during Day 2 of Islet Study Group 2023. Hear from Dr. Burcak Yesildag from InSphero as she discusses offers from the company.

Heard on the Street: Patrick MacDonald, PhD, University of Alberta

Wed, 21 Jun 2023 16:59:28 -0700

Check out “Heard on the Street” recorded during Day 1 of Islet Study Group 2023. Hear from Dr. Patrick MacDonald from University of Alberta as he discusses his lab and his takeaways from the conference thus far.

Heard on the Street: Manuj Bandral, PhD Candidate, TU Dresden

Wed, 21 Jun 2023 16:53:51 -0700

Check out “Heard on the Street” recorded during the Day 1 Poster session at Islet Study Group 2023. Hear from Manuj Bandral from TU Dresden as he discusses his poster: Islet clusters as mini-organs for diabetes therapies.

Heard on the Street: Mark Andrade, MD PhD Candidate, University of Washington

Tue, 20 Jun 2023 20:45:56 -0700

Check out “Heard on the Street” recorded during Day 1 of the Islet Study Group 2023 poster session. Hear from Mark Andrade a MD PhD Candidate at University of Washington as he discusses his poster: Unlocking beta-cell replication through the manipulation of αΕ-catenin function.

Heard on the Street: Vira Kravets, PhD, UCSD

Tue, 20 Jun 2023 20:36:44 -0700

Check out “Heard on the Street” recorded during Day 1 of Islet Study Group 2023. Hear from Dr. Vira Kravets from UCSD as she discusses her lab's work and highlights from her talk happening Day 2 of the conference.

Heard on the Street: Saleth Sidharthan, McGill University

Tue, 20 Jun 2023 20:26:44 -0700

Check out “Heard on the Street” recorded during Day 1 of the Islet Study Group 2023 poster session. Hear from Saleth Sidharthan a MS student at McGill University as he discusses his poster: A perfusable bioartificial islet encapsulation device to treat type-1 diabetes.

Heard on the Street: Francis Lynn, PhD, University of British Columbia

Tue, 20 Jun 2023 20:18:50 -0700

Check out “Heard on the Street” recorded during Day 1 of Islet Study Group 2023. Hear from Dr. Francis Lynn from University of British Columbia as he discusses his thoughts on the conference so far.

Heard on the Street: Julie Sneddon, PhD, UCSF

Tue, 20 Jun 2023 20:01:19 -0700

Check out “Heard on the Street” recorded during Day 1 of Islet Study Group 2023. Hear from Dr. Julie Sneddon from UCSF as she discusses highlights of her talk at the conference, about the Cell finder tool, and the future of the lab.

Heard on the Street: Teresa Rodriguez-Calvo, PhD, Helmholtz Munich - Institute of Diabetes Research

Tue, 20 Jun 2023 19:39:54 -0700

Check out “Heard on the Street” recorded during Day 1 of Islet Study Group 2023. Hear from Dr. Teresa Rodriguez-Calvo from Helmholtz Munich - Institute of Diabetes Research as she discusses her research.

Heard on the Street: Barak Blum, PhD, University of Wisconsin-Madison

Tue, 20 Jun 2023 19:15:13 -0700

Check out “Heard on the Street” recorded during Day 1 of Islet Study Group 2023. Hear from Dr. Barak Blum from university of wisconsin-madison as he discusses his research.

Heard on the Street: Peter Thompson, PhD, University of Manitoba

Tue, 20 Jun 2023 19:09:16 -0700

Check out “Heard on the Street” recorded during Day 1 of Islet Study Group 2023. Hear from Dr. Peter Thompson from University of Manitoba as he discusses his research and thoughts on the conference.

Heard on the Street: Jim Johnson, PhD, Vancouver, BC

Sun, 04 Jun 2023 18:50:10 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Dr. Jim Johnson from University of British Columbia as he discusses his thoughts on the conference and the Western Islet Study Group.

Heard on the Street: David Klatzmann, MD PhD, Paris, France

Sun, 04 Jun 2023 18:50:03 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Dr. David Klatzmann from Sorbonne University as he discusses his thoughts on the conference and discusses his thoughts on new treatments for type one diabetes.

Heard on the Street: Emma Hamilton-Williams, PhD, Brisbane, Australia

Sun, 04 Jun 2023 18:49:52 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Dr. Emma Hamilton-Williams from University of Queensland as she discusses her thoughts on the conference.

Heard on the Street: Raffael Ott, PhD, Oberschleißheim, Germany

Sun, 04 Jun 2023 18:49:44 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Dr. Raffael Ott from Helmholtz Munich as he discusses his poster on Maternal type 1 diabetes is associated with blood DNA methylation changes in young offspring.

Heard on the Street: Gabriele Sassi, PhD Candidate, Leuven, Belgium

Sun, 04 Jun 2023 18:49:35 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from PhD student Gabriele Sassi from KU Leuven as he discusses his thoughts on the conference.

Heard on the Street: Irina Buckle, PhD, Brisbane, Australia

Sun, 04 Jun 2023 18:49:26 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Dr. Irina Buckle from University of Queensland as she discusses her poster on Targeting RAGE using an oral antagonist to prevent Type 1 diabetes in NOD mice.

Heard on the Street: David Repaske, MD PhD, Charlottesville, Virginia

Sun, 04 Jun 2023 18:49:19 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Dr. David Repaske from University of Virginia as he discusses his thoughts on the conference.

Heard on the Street: Coralie Alabert and Mathias Høj Jensen

Sun, 04 Jun 2023 18:49:11 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Ms. Coralie Alabert and Mr. Mathias Høj Jensen as they share their thoughts on the conference from a patient perspective.

Heard on the Street: Chantal Mathieu, MD PhD, Leuven, Belgium

Sun, 04 Jun 2023 18:49:03 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Dr. Chantal Mathieu from Katholieke Universiteit as she discusses her thoughts on the conference and the next steps for INNODIA.

Heard on the Street: Lauren Higdon, PhD, San Francisco, California

Sun, 04 Jun 2023 18:48:54 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Dr. Lauren Higdon from the Immune Tolerance Network as she discusses her poster on Aged T cells are increased in new onset type 1 diabetes patients.

Heard on the Street: Mathias Høj Jensen, PhD Candidate, Copenhagen, Denmark

Sun, 04 Jun 2023 18:48:44 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from PhD candidate Mathias Jensen from University of Copenhagen as he discusses his poster on Pancreatic dysregulation of innate antiviral immune pathways in type 1 diabetes.

Heard on the Street: Matthew Brown and Mollie Huber, Gainesville, Florida

Sun, 04 Jun 2023 18:48:38 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Matthew Brown and Mollie Huber from University of Florida as they share their thoughts on the conference.

Heard on the Street: Richard Oram, Jamie Felton, Emily Sims, Kurt Griffin

Sun, 04 Jun 2023 18:48:31 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Richard Oram, Jamie Felton, Emily Sims, and Kurt Griffin as they share their thoughts on the conference.

Heard on the Street: Shanice Lewis, PhD Candidate, Bristol, England

Sun, 04 Jun 2023 18:48:24 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from PhD candidate Shanice Lewis from University of Bristol as she discusses her poster on Frequency of islet autoantibodies of relatives with Type 2 Diabetes in the BOX cohort.

Heard on the Street: Tim Tree, PhD, London, England

Sun, 04 Jun 2023 18:48:18 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Dr. Tim Tree from King’s College as he shares his thoughts on the conference.

Heard on the Street: Yi-Chun Chen, Vancouver, BC

Sun, 04 Jun 2023 18:48:11 -0700

Check out “Heard on the Street” recorded during IDS Paris 2023. Hear from Dr. Yi-Chun Chen from University of British Columbia as she shares her thoughts on the conference.

Heard on the Street: Maria Bettini, PhD, University of Utah

Wed, 24 May 2023 13:23:03 -0700

Check out "Heard on the Street" recorded during the IDS Paris 2023 Day 1 Poster session. Hear from Dr. Maria Bettini from University of Utah as she discusses recruitment of stem-like T cells and exhaustion resistance support CD4 T cells in autoimmunity.

Heard on the Street: Remi Creusot, PhD, Columbia

Wed, 24 May 2023 12:55:52 -0700

Check out "Heard on the Street" recorded during the IDS Paris 2023 Day 1 Poster session. Hear from Dr. Remi Creusot from Columbia University as he discusses in vivo reprograming of stromal cells for tolerogenic immunotherapy of Type 1 diabetes.

Find his poster on twitter: https://twitter.com/thesugarscience/status/1661461853627621377?s=20

Episode 189: Francois Pattou, MD, University of Lille

Thu, 18 May 2023 07:50:20 -0700

In this episode, Francois Pattou joins us to discuss association between primary graft function and 5-year outcomes of islet allogenic transplantation in Type 1 diabetes: a retrospective, multicentre, observational cohort study in 1210 patients from the Collaborative Islet Transplant Registry.

We apologize that some of the audio quality is poor near the middle and end time points.

Episode 188: Joe Qiao Zhou PhD, and Lauretta Lacko PhD, Weill Cornell

Wed, 17 May 2023 11:26:15 -0700

In this episode, Joe Qiao Zhou and Lauretta Lacko join us to introduce the HUMAN THERAPEUTIC ORGANOID CORE (HTOC) at Weill Cornell.

Episode 187: Stefan Ledinger, Director, Biocrates

Tue, 16 May 2023 06:00:00 -0700

In this episode, Stefan Ledinger joins us to discuss T1D as a complex metabolic disease: metabolomics as a tool to explore pathophysiology and enable personalized medicine.

Episode 186: Daniel Espes, MD PhD, Uppsala University and SciLifeLab

Mon, 15 May 2023 06:00:00 -0700

In this episode, Daniel Espes joins us to discuss classifying hypoglycemic events with machine learning algorithms.

Episode 185: Joe Qiao Zhou PhD, and Steve Xiaofeng Huang PhD, Weill Cornell

Wed, 10 May 2023 06:00:00 -0700

In this episode, Joe Qiao Zhou and Steve Xiaofeng Huang discuss their talk Restoring Glucose Homeostasis with Stomach-derived human insulin-secreting organoids.

Episode 184: Holger Russ, PhD, University of Florida

Tue, 09 May 2023 06:00:00 -0700

In this episode, Holger Russ joins us to discuss generation of functional thymic organoids from human pluripotent stem cells.

Episode 183: Eric Chang, PhD, Feinstein Institutes for Medical Research Northwell

Mon, 08 May 2023 06:00:00 -0700

In this episode, Eric Chang joins us to discuss making brain-body and neuro-immune connections with the vagus nerve.

Episode 182: Olga Gornik PhD, and Najda Rudman PhD, University of Zagreb

Mon, 10 Apr 2023 06:00:00 -0700

In this episode, Drs. Olga Gornik and Najda Rudman discuss their talk N-glycosylation and its genetic regulation in type 1 diabetes, Sweet solution to diabetes?

Episode 181: Caroline Miranda, PhD, University of Oxford and Haiqiang Dou, PhD, University of Göthenburg

Thu, 06 Apr 2023 13:07:33 -0700

In this episode, Caroline Miranda and Haiqiang Dou discuss disturbance of cell-cell crosstalk in type 1 diabetes.

Episode 180: Gladys Teitelman, PhD, SUNY Downstate

Wed, 05 Apr 2023 06:00:00 -0700

In this episode, Gladys Teitelman discusses the human beta cell: victim or instigator of Type 1 Diabetes development?

Episode 179: Karl Bacos, PhD, Lund University Diabetes Center, Sweden

Tue, 04 Apr 2023 05:38:13 -0700

In this episode, Karl Bacos joins us to discuss an interdisciplinary topic: PAX5 - a new player in T2D pathophysiology.

Episode 178: Billur Akkaya, MD DPhil, Ohio State

Fri, 24 Mar 2023 09:00:00 -0700

In this episode, Billur Akkaya joins us to discuss deciphering the specificity and molecular mechanisms of regulatory T cells using novel approaches.

Episode 177: Antonio Citro, PhD, San Raffaele Hospital

Thu, 23 Mar 2023 09:01:06 -0700

In this episode, Antonio Citro joins us to discuss directed self assembly of a xenogeneic vascularized endocrine pancreas for type 1 diabetes. Due to some technical difficulties, there are a few cuts at the end that would be better understood by viewing the linked YouTube video.

Episode 176: Josephine Forbes, MD PhD, and Sherman Leung, PhD, University of Queensland

Thu, 16 Mar 2023 21:26:14 -0700

In this episode, Josephine Forbes and Sherman Leung join us to discuss all the RAGE….A novel target for prevention of type 1 diabetes.

Episode 175: Laura Jacobsen, MD, University of Florida

Tue, 14 Mar 2023 15:27:38 -0700

In this episode, Laura Jacobsen joins us to discuss the Emerging Biomarkers of Response to Immunotherapies.

Episode 174: Mohsen Khosravi Maharlooei, PhD, Mayo Clinic Arizona

Mon, 13 Mar 2023 07:00:00 -0700

In this episode, Mohsen Khosravi Maharlooei joins us to discuss the role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice.

Episode 173: Ruth Elgamal, PhD Candidate, UCSD

Thu, 09 Mar 2023 16:00:00 -0800

In this episode, Ruth Elgamal from the Kyle Gaulton lab at UCSD joins us to discuss an integrated pancreatic islet reference map: creating accessible tools and resources. In this talk Ruth does many live demos, if you would like to watch the paired video head over to our YouTube channel: https://www.youtube.com/@thesugarscience8602

Episode 172: Martin Hessner, PhD, and Pinar Sargin, MD, University of Wisconsin and Wellington Regional Medical Center

Mon, 13 Feb 2023 14:00:00 -0800

In this episode, Martin Hessner and Pinar Sargin join us to discuss L. plantarum probiotic supplementation and diet – synergistic effect in T1D prevention in rats.

Episode 171: Klaus Kaestner, PhD, HPAP

Thu, 09 Feb 2023 06:00:00 -0800

In this episode, Klaus Kaestner joins us to discuss the Human Pancreas Analysis Program (HPAP) and how it is enabling new insights into type 1 diabetes.

Episode 170: Hashem Koohy, PhD, Oxford

Wed, 08 Feb 2023 06:00:00 -0800

In this episode, Hashem Koohy joins us to discuss computational and machine-learning prediction of CD8 T cells’ target.

Episode 169: Mike Haller, MD, TrialNet

Tue, 07 Feb 2023 06:00:00 -0800

In this episode, Mike Haller joins us to discuss updates at TrialNet.

Episode 168: Mia Øgaard Mønsted, PhD, and Martin Haupt-Jorgensen, PhD, Bartholin Institute

Mon, 06 Feb 2023 07:02:21 -0800

In this episode, Mia Øgaard Mønsted and Martin Haupt-Jorgensen join us to discuss the role of the intestine in the development of type 1 diabetes.

Episode 167: Lulu Jiang, MD PhD, Boston University

Wed, 18 Jan 2023 12:00:00 -0800

In this episode, Lulu Jiang joins us to discuss stress granules and their connections to neurodegeneration.

Episode 166: Alberto Pugliese, MD, City of Hope

Tue, 17 Jan 2023 08:40:24 -0800

In this episode, Alberto Pugliese joins us to discuss new leadership and opportunities in Type 1 Diabetes Research at City of Hope.

Episode 165: Esteban Gurzov, PhD, Université Libre de Bruxelles

Fri, 06 Jan 2023 09:20:32 -0800

In this episode, Esteban Gurzov joins us to discuss fixing dysfunctional signaling in type 1 diabetes, are we on the right track or a lost cause?

Episode 164: Francois Moreau, PhD, Harvard Joslin Diabetes Center

Tue, 03 Jan 2023 10:02:28 -0800

In this episode, Francois Moreau joins us to discuss the unique interaction of a viral insulin-like peptide with the IGF-1 receptor which produces a natural antagonist.

Episode 163: Kevan Herold, MD, Yale and Matthias Von Herrath, MD, UCSD

Mon, 28 Nov 2022 08:00:00 -0800

In this episode, Kevan Herold and Matthias Von Herrath join us to discuss opportunities for Teplizumab in the treatment of Type 1 diabetes.

Episode 162: Xiaoyan Yi, PhD, ULB Center for Diabetes Research

Fri, 18 Nov 2022 08:53:22 -0800

In this episode, Xiaoyan Yi joins us to discuss mining the transcriptome of target tissues of autoimmune and degenerative pancreatic beta-cell and brain diseases to discover therapies.

Episode 161: Heather Denroche, PhD, UBC

Tue, 15 Nov 2022 08:00:00 -0800

In this episode, Heather Denroche joins us to discuss islet amyloid in type 1 diabetes: a paradox in immune-mediated beta-cell loss.

Episode 160: Per-Ola Carlsson, MD PhD, NextCell Pharma

Mon, 14 Nov 2022 08:00:00 -0800

In this episode, Per-Ola Carlsson joins us to discuss Mesenchymal stromal cells to intervene in the development of type 1 diabetes.

Episode 159: Chih-Wei Logan Hsu, PhD, Baylor College

Mon, 31 Oct 2022 08:00:00 -0700

In this episode, Chih-Wei Logan Hsu joins us to discuss EZ Clear for simple, rapid, and robust mouse whole organ clearing.

Episode 158: Slavica Tudzarova, PhD, UCLA

Mon, 24 Oct 2022 08:00:00 -0700

In this episode, Slavica Tudzarova joins us to discuss the beta-cell uphill battle in type 1 diabetes.

https://thesugarscience.org/ask-the-expert/

Episode 157: New Talent: Carolyn McGrail, PhD candidate, UCSD

Wed, 19 Oct 2022 08:00:00 -0700

In this episode, Carolyn McGrail from the Dr. Kyle Gaulton lab joins us to discuss fine-mapping Type 1 Diabetes risk variants in the MHC.

https://thesugarscience.org/ask-the-expert/

Episode 156: Ed Phelps, PhD, University of Florida

Tue, 18 Oct 2022 08:00:00 -0700

In this episode, Ed Phelps joins us to discuss pancreas slices to study interactions between immune cells and islets. *Please note there are a lot of videos presented in this ATE, to see a video of this talk please navigate to our YouTube channel theSugarScience.*

https://thesugarscience.org/ask-the-expert/

Episode 155: Eddie James, PhD, Benaroya Research Institute

Mon, 17 Oct 2022 08:00:00 -0700

In this episode, Eddie James joins us to discuss applying in depth studies of beta cell specific T cells to understand disease progression and response to therapy.

https://thesugarscience.org/ask-the-expert/

Episode 154: Chris Fraker, PhD, and Allison Bayer, PhD, Diabetes Research Institute Foundation

Fri, 14 Oct 2022 08:00:00 -0700

In this episode, Chris Fraker and Allison Bayer join us to discuss the role of Natural Killer (NK) cells in context of T1D.

https://thesugarscience.org/ask-the-expert/

Episode 153: Chantal Mathieu, MD PhD, Innodia

Thu, 13 Oct 2022 08:00:00 -0700

In this episode, Chantal Mathieu joins us to discuss Innodia, a private public partnership against Type 1 Diabetes.

https://thesugarscience.org/ask-the-expert/

Episode 152: Sara Tersey, PhD, and Raghu Mirmira, PhD, UChicago

Wed, 12 Oct 2022 08:00:00 -0700

In this episode, Sara Tersey and Raghu Mirmira join us to discuss proinflammatory signaling in β cells that trigger islet autoimmunity.

https://thesugarscience.org/ask-the-expert/

Episode 151: Ulf Hanielius, CEO and PhD, and Elna Narula, RN, Diamyd Medical

Tue, 11 Oct 2022 08:00:00 -0700

In this episode, Ulf Hanielius and Elna Narula join us to discuss Diamyd Medical and the opportunity for GAD vaccines.

https://thesugarscience.org/ask-the-expert/

Episode 150: Frances Ashcroft, PhD, University of Oxford, and Barbara Corkey, PhD, Boston University

Mon, 10 Oct 2022 08:02:00 -0700

In this episode, Frances Ashcroft and Barbara Corkey join us to discuss a new paper titled metabolic cycles and signals for insulin secretion which challenges a key aspect of the “canonical” model. Matthew Merrins, PhD, University of Wisconsin-Madison additionally contributes significantly to the conversation.

https://thesugarscience.org/ask-the-expert/

Episode 149: Tarin Bigley, MD PhD, Washington University School of Medicine in St. Louis

Fri, 07 Oct 2022 06:31:24 -0700

In this episode, Tarin Bigley joins us to discuss neonatal roseolovirus infection induces disruption of thymic tolerance and results in autoimmunity and autoantibodies, including anti-insulin antibodies.

https://thesugarscience.org/ask-the-expert/

Episode 148: Alex Abramson, PhD, Georgia Tech

Fri, 07 Oct 2022 06:02:32 -0700

In this episode, Alex Abramson joins us to discuss oral delivery of Insulin and other Macromolecule Therapeutics using Self-Orienting Pills.

https://thesugarscience.org/ask-the-expert/

Episode 147: Joaquin Reyna, PhD candidate, La Jolla Institute of Technology

Thu, 06 Oct 2022 23:47:56 -0700

In this episode, Joaquin Reyna joins us to discuss his team’s journey to winning the D Challenge 2021. Specifically by exploring the Genetics of Type 1 Diabetes through GWAS, eQTLs, Chromatin Looping.

https://thesugarscience.org/ask-the-expert/

Episode 146: Juan Jaume, MD, University of Toledo

Thu, 06 Oct 2022 22:47:20 -0700

In this episode, Dr. Jaume joins us to discuss the homing of Antigen-Specific CAR T Regulatory Cells to Human Pancreatic Islets and Pre-clinical Type 1 Diabetes Reversal.

https://thesugarscience.org/ask-the-expert/

Episode 145: New Talent: Tanmay Mathur with Abhishek Jain, PhD, Texas A&M

Thu, 18 Aug 2022 12:03:35 -0700

In this episode, Tanmay Mathur and Abhishek Jain join us to discuss engineering diabetes with personalized and vascularized organ-chips.

https://thesugarscience.org/ask-the-expert/

Episode 144: Alok Joglekar, PhD, University of Pittsburgh

Wed, 27 Jul 2022 16:22:31 -0700

In this episode, Dr. Joglekar joins us to discuss T cell antigen discovery in T1D: Experimental and Computational.

https://thesugarscience.org/ask-the-expert/

Episode 143: William Rust, PhD, Seraxis

Wed, 27 Jul 2022 10:09:19 -0700

In this episode, Dr. Rust joins us to discuss lab-grown islets for islet replacement therapy in the clinic.

https://thesugarscience.org/ask-the-expert/

Episode 142: Shmuel Levit, MD, PhD, LEVICURE

Tue, 26 Jul 2022 16:19:28 -0700

In this episode, Dr. Levit joins us to discuss T1D remission and beta cell regeneration, induced by oral administration of combo of DDP-4 inhibitor, PPI and GABA in NOD mice and human patients.

https://thesugarscience.org/ask-the-expert/

Episode 141: Kalpana Mandal, PhD, Terasaki Institute Terasaki Institute

Mon, 25 Jul 2022 15:13:14 -0700

In this episode, Dr. Mandal joins us to discuss oxygen generating Microparticles for ischemic injury.

https://thesugarscience.org/ask-the-expert/

Episode 140: Chenqu Suo, MB BChir, Wellcome Sanger Inst, Teichmann Lab

Mon, 25 Jul 2022 12:19:28 -0700

In this episode, Dr. Suo joins us to discuss mapping the developing human immune system across organs.

https://thesugarscience.org/ask-the-expert/

Episode 139: Remi Creusot, PhD, Columbia

Mon, 25 Jul 2022 11:00:09 -0700

In this episode, Dr. Creusot joins us to discuss epitope-based tolerance-inducing immunotherapy for Type 1 Diabetes: the road to precision medicine.

https://thesugarscience.org/ask-the-expert/

Episode 138: Braulio Marfil Garza, PhD, and James Shapiro, PhD, University of Alberta

Sun, 24 Jul 2022 23:46:01 -0700

In this episode, Dr. Marfil Garza and Dr. Shapiro join us to discuss pancreatic islet transplantation in Type 1 Diabetes: 20-year outcomes.

https://thesugarscience.org/ask-the-expert/

Introducing the DiabDOCS National Physician Scientist Training Program

Fri, 22 Jul 2022 23:37:09 -0700

In this episode, Dr. DiMeglio and Dr. Maahs join us to talk about the details of the National NIH K12 “Diabetes-Docs: Physician-Scientist Career Development Program” (DiabDocs).

Episode 137: Andres Garcia, PhD, Georgia Tech

Sat, 09 Jul 2022 11:52:43 -0700

In this episode, Dr. Garcia joins us to discuss biomaterials for transplantation of insulin-producing cells.

https://thesugarscience.org/ask-the-expert/

Episode 136: Piotr Witowski, MD, PhD, and Peter Senior, PhD, (FDA)

Sat, 09 Jul 2022 01:30:14 -0700

In this episode, Dr. Witowski and Dr. Senior join us to discuss working with the FDA to allow greater access to islet transplant in the US.

https://thesugarscience.org/ask-the-expert/

Episode 135: Bobbie-Jo Webb-Robertson, PhD, and Briggitte Frohnert, MD, PhD

Sat, 09 Jul 2022 01:17:59 -0700

In this episode, Dr. Bobbie-Jo Webb-Robertson and Dr. Briggitte Frohnert join us to discuss machine learning integration for outcomes of type 1 diabetes.

https://thesugarscience.org/ask-the-expert/

Episode 134: Alice Carr, PhD, and Sarah Richardson, PhD, University of Exeter

Fri, 08 Jul 2022 19:23:04 -0700

In this episode, Dr. Alice Carr and Dr. Sarah Richardson join us to discuss circulating C-peptides in children and young people, and pancreatic beta-cell loss in pancreas donors across T1D duration.

https://thesugarscience.org/ask-the-expert/

Episode 133: Elad Sintov, PhD, Harvard

Fri, 08 Jul 2022 00:27:41 -0700

In this episode, Dr. Elad Sintov joins us from the Melton Lab at Harvard to discuss deciphering the immunogenicity of stem cell-derived islets and ways to dampen it.

https://thesugarscience.org/ask-the-expert/

Episode 132: Nayara Leite, PhD, Vertex Pharmaceuticals

Thu, 07 Jul 2022 22:06:05 -0700

In this episode, Dr. Nayara Leite joins us again to discuss what's new with her research at Vertex Pharmaceuticals.

https://thesugarscience.org/ask-the-expert/

Episode 131: Emrah Altindis, PhD, Boston College

Tue, 21 Jun 2022 00:41:30 -0700

In this episode, Dr. Emrah Altindis joins us to discuss how gut microbiota regulate pancreatic growth, exocrine function, and gut hormones.

https://thesugarscience.org/ask-the-expert/

Episode 130: Stephen Gray, PhD, Ourobionics

Tue, 03 May 2022 22:46:03 -0700

In this episode, Dr. Stephen Gray joins us to discuss the potential of blockchain technology for rewarding scientists and a regenerative medicine meta verse.

https://thesugarscience.org/ask-the-expert/

Episode 129: Jack Virostko, PhD, UT Austin

Thu, 28 Apr 2022 23:02:35 -0700

In this episode, Dr. Jack Virotsko joins us to discuss imaging the pancreas in Type 1 Diabetes: Monitoring the Crime Scene.

https://thesugarscience.org/ask-the-expert/

Episode 128: Ping Wang, PhD, Michigan State University

Tue, 26 Apr 2022 23:24:48 -0700

In this episode, Dr. Ping (Peter) Wang joins us to discuss the trends of nanotechnology in type 1 diabetes treatment.

https://thesugarscience.org/ask-the-expert/

Episode 127: Abhishek Kulkarni, PhD, University of Chicago

Thu, 21 Apr 2022 22:12:57 -0700

In this episode, Dr. Abhishek Kulkarni joins us to discuss 12-LOX: a critical enzyme in the initiation and progression of T1D.

https://thesugarscience.org/ask-the-expert/

Episode 126: James Heather, PhD, Mass General Hospital Cancer Center

Tue, 19 Apr 2022 10:00:00 -0700

In this episode, Dr. James Heather joins us to discuss Stitchr: a tool for making and modifying T cell receptor sequences.

https://thesugarscience.org/ask-the-expert/

Episode 125: Teresa De Toni, PhD Candidate, University of Miami

Thu, 14 Apr 2022 21:59:11 -0700

In this episode, PhD candidate Teresa De Toni joins us to discuss parallel evaluation of polyethylene glycol conformal coating and alginate microencapsulation as immunoisolation strategies for pancreatic islet transplantation.

https://thesugarscience.org/ask-the-expert/

Episode 124: Anath Shalev, PhD, University of Alabama at Birmingham

Tue, 12 Apr 2022 23:13:16 -0700

In this episode, Dr. Anath Shalev joins us to discuss more verapamil effects in T1D.

https://thesugarscience.org/ask-the-expert/

Episode 123: Julia Panzer, PhD, and Alejandro Caicedo, PhD, University of Miami

Wed, 02 Mar 2022 13:28:40 -0800

In this episode, Dr. Julia Panzer and Dr. Alejandro Caicedo join us to discuss targeting the pancreatic alpha cell to prevent hypoglycemia in Type 1 Diabetes.

https://thesugarscience.org/ask-the-expert/

Episode 122: Rohit Kulkarni, MD, PhD, Joslin Diabetes/Harvard Medical School

Thu, 24 Feb 2022 22:38:21 -0800

In this episode, Dr. Kulkarni joins us to discuss cross-talk between pancreatic endocrine and exocrine cells to decipher T1D.

https://thesugarscience.org/ask-the-expert/

Episode 121: Lorenzo Pasquali, PhD, Pompeu Fabra University

Wed, 23 Feb 2022 00:00:37 -0800

In this episode, Dr. Lorenzo Pasquali joins us from Pomepeu Fabra University in Barcelona to discuss beta cell noncoding regulatory functions and T1D.

https://thesugarscience.org/ask-the-expert/

Episode 120: Amparo Guemes Gonzalez, PhD, University of Cambridge

Thu, 17 Feb 2022 22:58:51 -0800

In this episode, Dr. Amparo Guemes Gonzalez joins us to discuss how bioelectronic medicine is bringing innovation to the treatment of T1D.

https://thesugarscience.org/ask-the-expert/

Episode 119: Gayle Boxx, PhD, and Jan Mrazek, PhD, Aukera Inc.

Wed, 16 Feb 2022 23:21:10 -0800

In this episode, Drs. Gayle Boxx and Jan Mrazek join us to discuss how vaults intersect with autoimmunity.

https://thesugarscience.org/ask-the-expert/

Episode 118: Emma Hamilton-Williams, PhD, University of Queensland

Wed, 09 Feb 2022 21:36:13 -0800

In this episode, Dr. Emma Hamilton-Williams joins us to discuss targeting the gut microbiota as a new therapy for T1D.

https://thesugarscience.org/ask-the-expert/

Episode 117: Richard Benninger, PhD, University of Colorado

Wed, 02 Feb 2022 23:20:02 -0800

In this episode, Dr. Richard Benninger from the Barbara Davis Center at CU joins us to discuss the question, "Is there a pulsatile pacemaker in islet cells?"

https://thesugarscience.org/ask-the-expert/

Episode 116: Andrea Schietinger, PhD, Memorial Sloan Kettering

Thu, 27 Jan 2022 15:46:44 -0800

In this episode, Andrea Schietinger joins us to discuss the autoimmune stem-like CD8 T cell population that drives type 1 diabetes.

https://thesugarscience.org/ask-the-expert/

Episode 115: Alma-Martina Cepika, MD, PhD, Stanford

Tue, 25 Jan 2022 08:51:16 -0800

In this episode, Dr. Alma-Martina Cepika joins us to discuss antigen-specific type 1 regulatory T cells, including their mechanism of function and therapeutic use.

https://thesugarscience.org/ask-the-expert/

Episode 114: Ester Caffarel-Salvador, PhD, MIT

Tue, 18 Jan 2022 22:58:39 -0800

In this episode, Dr. Ester Caffarel-Salvador joins us to discuss oral insulin.

https://thesugarscience.org/ask-the-expert/

Episode 113: John Glass, PhD, and Yo Suzuki, PhD, J. Craig Venter Institute

Thu, 13 Jan 2022 21:50:35 -0800

In this episode, Dr. John Glass and Dr. Yo Suzuki from the J. Craig Venter Institute in Maryland join us to discuss metabolic engineering and how it might transform skin bacteria into insulin producers.

https://thesugarscience.org/ask-the-expert/

Episode 112: Karsten Buschard, MD, and Kristina Pedersen, PhD, Rigshospitalet, Denmark

Tue, 11 Jan 2022 18:13:58 -0800

In this episode, Dr. Buschard and Dr. Pedersen join us to discuss dysregulation of the innate antiviral immune system in type 1 diabetes.

https://thesugarscience.org/ask-the-expert/

Episode 111: Maria Jose Redondo, MD, PhD, Baylor University

Thu, 06 Jan 2022 19:50:29 -0800

In this episode, Dr. Maria Jose Redondo joins us to discuss what's new with TCG7L2 and insulin sensitivity.

https://thesugarscience.org/ask-the-expert/

Episode 110: Ron Weiss, PhD, MIT

Tue, 04 Jan 2022 22:04:05 -0800

In this episode, Dr. Ron Weiss joins us to discuss an engineered protein-phosphorylation toggle network with implications for endogenous network discovery.

https://thesugarscience.org/ask-the-expert/

Episode 109: Jessica Weaver, PhD, ASU

Thu, 16 Dec 2021 21:51:21 -0800

In this episode, Dr. Jessica Weaver joins us to discuss eliminating immune suppression in cell therapies to treat type 1 diabetes.

https://thesugarscience.org/ask-the-expert/

Episode 108: Mark Huising, PhD, UC Davis

Tue, 14 Dec 2021 21:07:48 -0800

In this episode, Dr. Mark Huising joins us to discuss observing islet cell behavior in real time.

https://thesugarscience.org/ask-the-expert/

Episode 107: Patricia Aparicio-Domingo, PhD, ABcam

Fri, 10 Dec 2021 15:57:12 -0800

In this episode, Dr. Patricia Aparicio-Domingo joins us to discuss what's new at ABcam, a leading supplier of protein research tools.

https://thesugarscience.org/ask-the-expert/

Episode 106: Milena Pavlovic and Lonneke Scheffer, ImmuneML

Wed, 08 Dec 2021 22:40:22 -0800

In this episode, Milena Pavlovic and Lonneke Scheffer join us to discuss ImmuneML, an "open-source ecosystem for machine learning analysis of adaptive immune receptor repertoires".

ImmuneML Website: https://immuneml.uio.no/

https://thesugarscience.org/ask-the-expert/

Episode 105: Jennifer Wang, MD, UMass and Decio L. Eizirik, MD, PhD, ULB

Thu, 02 Dec 2021 21:35:10 -0800

In this episode, Dr. Jennifer Wang and Dr. Decio Eizirik join us to discuss T1 interferons and autoimmune diseases.

https://thesugarscience.org/ask-the-expert/

Episode 104: Dario Gerace, PhD, Harvard

Tue, 30 Nov 2021 21:29:29 -0800

In this episode, Dr. Dario Gerace joins us to discuss engineering immune-evasive stem cell-derived islet cells.

https://thesugarscience.org/ask-the-expert/

Episode 103: Austin Lefebvre, PhD, UCI

Tue, 23 Nov 2021 10:55:59 -0800

In this episode, Dr. Austin Lefebvre joins us to discuss mitochondrial causes and consequences in diabetes.

https://thesugarscience.org/ask-the-expert/

Episode 102: Ana Conesa, PhD, UF

Thu, 18 Nov 2021 22:44:57 -0800

In this episode, Dr. Ana Conesa joins us to discuss multi-OMICs modeling of T1D linking lipid impairment with T1D onset.

https://thesugarscience.org/ask-the-expert/

Episode 101: Haiting Ma, PhD, MIT

Tue, 16 Nov 2021 17:25:26 -0800

In this episode, Dr. Haiting Ma joins us to discuss a synthetic immune system and how it implicates beta-cell pyroptosis during T-cell mediated autoimmunity.

https://thesugarscience.org/ask-the-expert/

Episode 100: Cassie Robertson, PhD, UVA

Thu, 11 Nov 2021 10:50:21 -0800

In this episode, Dr. Cassie Robertson joins us to discuss the discovery and characterization of genetic susceptibility loci in T1D.

https://thesugarscience.org/ask-the-expert/

Episode 99: Decio L. Eizirik, MD, PhD, ULB

Tue, 09 Nov 2021 12:00:00 -0800

In this episode, Dr. Decio Eizirik joins us to discuss the misguided dialog between beta cells and the immune system in T1D.

https://thesugarscience.org/ask-the-expert/

Episode 98: Yasmin Mohseni, PhD, King‘s College London

Thu, 04 Nov 2021 22:27:00 -0700

In this episode, Dr. Yasmin Mohseni joins us to discuss CAR-Treg therapy and immunomodulation.

https://thesugarscience.org/ask-the-expert/

Episode 97: Michele Solimena, MD, PhD, TU Dresden

Tue, 02 Nov 2021 16:56:31 -0700

In this episode, Dr. Michele Solimena joins us for a deep dive into beta-cell biology.

https://thesugarscience.org/ask-the-expert/

Episode 96: Jeff Bluestone, PhD

Thu, 21 Oct 2021 12:39:53 -0700

Dr. Jeff Bluestone and others join us to discuss Tregs and Sonoma Bio.

This episode is in Ask the Expert style

Ask the Expert is a 30 minute digital cafe experience where scientists and grad students can meet up and exchange with thought leaders in the field of type one diabetes.

Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Episode 95: Roberto Mallone, MD, PhD, INSERM FR

Sun, 12 Sep 2021 11:59:36 -0700

Dr. Robert Mallone joins us to discuss T-Cell Epitopes and Neo-epitopes in Type 1 Diabetes: Reprogramming Tregs and other whole cell tweaks.

This episode is in Ask the Expert style

Ask the Expert is a 30 minute digital cafe experience where scientists and grad students can meet up and exchange with thought leaders in the field of type one diabetes.

Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Episode 94: Zach Freyberg, MD, PhD, UPITT

Thu, 26 Aug 2021 07:28:55 -0700

Dr. Zach Freyberg joins us to discuss new roles for dopamine as a pancreatic modulator of insulin and glucagon secretion.

This episode is in Ask the Expert style...

Ask the Expert is a ~30 minute digital cafe experience where scientists and grad students can meet up and exchange with thought leaders in the field of type one diabetes.

Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Episode 93: Graciela Lorca, PhD, UFLA

Thu, 19 Aug 2021 06:33:22 -0700

Dr. Graciela Lorca joins us to discuss microbiome probiotics & T1D

This episode is in Ask the Expert style

Ask the Expert is a 30 minute digital cafe experience where scientists and grad students can meet up and exchange with thought leaders in the field of type one diabetes.

Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert/

Episode 92: Megan Penno, PhD, ENDIA

Tue, 17 Aug 2021 15:39:51 -0700

Dr. Megan Penno joins us to discuss environmental determinants of islet autoimmunity.

This episode is in Ask the Expert format.

Ask the Expert is a 30 minute digital cafe experience where scientists and grad students can meet up and exchange with thought leaders in the field of type one diabetes.

Link below to sign up for a seat in the cafe!

https://thesugarscience.org/ask-the-expert

Episode 91: Maike Sander, MD, UCSD

Wed, 11 Aug 2021 09:00:00 -0700

Dr. Maike Sander joins us to discuss building human stem cell models to study beta cell demise in T1D.

https://thesugarscience.org/ask-the-expert/

Episode 90: Kyle Gaulton, PhD, UCSD

Fri, 30 Jul 2021 09:00:00 -0700

Dr. Kyle Gaulton joins us to discuss interpreting type 1 diabetes risk with genetics and single cell epigenetics.

This episode is in our Ask the Expert format.

https://thesugarscience.org/ask-the-expert/

Episode 89: Victoria Salem PhD, Imperial College London

Wed, 28 Jul 2021 09:00:00 -0700

Dr. Victoria Salem joins us to discuss in-vivo evidence for islet "hub cells".

https://thesugarscience.org/ask-the-expert/

Episode 88: Milena Pavlovic and Lonneke Scheffer, ImmuneML

Fri, 23 Jul 2021 09:00:00 -0700

Milena Pavlovic and Lenneke Schieffer join us to discuss Immune ML, an "open-source ecosystem for machine learning analysis of adaptive immune receptor repertoires.

ImmuneML website: https://immuneml.uio.no/

https://thesugarscience.org/ask-the-expert/

Episode 87: Braden Tierney, PhD, Harvard University

Wed, 21 Jul 2021 09:00:00 -0700

Dr. Braden Tierney joins us to discuss gene-level metagenomic architectures across diseases that yield high-resolution microbiome diagnostic indicators.

This episode is in our Ask the Expert style:

https://thesugarscience.org/ask-the-expert/

Episode 86: Carmen Valcarce PhD and Klara Klein MD PhD

Wed, 14 Jul 2021 09:00:00 -0700

In this Ask the Expert podcast we talk with Carmen Valcarce PhD and Klara Klein MD PhD from VTV Therapteutics. We discuss TTP399 development as an adjunct therapy to insulin in patients with Type 1 Diabetes.

This episode is in our Ask the Expert style:

https://thesugarscience.org/ask-the-expert/

Episode 85: SOS #4-What are the most promising approaches for beta cell replacement moving forward?

Tue, 13 Jul 2021 09:00:00 -0700

Topic: What are the most promising approaches for beta cell replacement moving forward?

Anchors: Doug Melton PhD (HSCI), Ali Naji MD PhD (PENN), Mike Rickles MD (PENN), Felicia Pagliuca PhD (Vertex) Matthias Hebrok PhD, (UCSF)

Panel: Jon Odorico MD (U Wisc), Pete Butler MD (UCLA) Cherie Stabler, PhD (UF), Mark Atkinson, PhD (UF), Ekaterine Bershivili MD PhD (UGeneva)

WHAT: State of the Science is an interactive conversation with room for granular and lively debate focused on the most pressing issues in type 1 diabetes (T1D) research. Our goal is to foster open science, interaction, and collaboration–all hallmarks of the(sugar)science mission.

These virtual conversations will involve:

30 minute introduction – What’s HOT in this field? Describing the state of the art.

20 minute panel interface – What does the future hold?

10 minutes – Audience Q/A WHO: Anchors (2) – introduce the topic, state of the art, and what’s happening in the field Panelists (3) – debate current hypotheses and postulate what the future folds

Audience (50-100) – contribute meaningful questions and insights

Link to our page: https://thesugarscience.org/state-of-...

Episode 84: Jessica Kenison, PhD, Brigham and Women's Hospital

Sat, 10 Jul 2021 09:00:00 -0700

Dr. Jessica Kenison joins us to discuss re-balancing the immune system and introducing antigen-specific immune tolerance to treat T1D.

Dr. Jessica Kennison is a Postdoctoral Research Fellow at Brigham and Women's Hospital and Scientist at AnTolRx, Inc.

This episode is in our Ask the Expert style:

https://thesugarscience.org/ask-the-expert/

Episode 83: Teresa Mastracci, PhD, Indiana University

Thu, 10 Jun 2021 09:00:00 -0700

In this episode, Dr. Teresa Mastracci joins us to discuss the exocrine pancreas in T1D; is it a player, or merely a spectator?

Dr. Mastracci is an Assistant Professor in Biology at Indiana University. In 2017 she was named one of the top Ten Under 40 up & coming stars in Biopharma Research and Business by Genetic Engineering News and was recognized as one of the Indianapolis Business Journal’s Forty Under 40.

This episode is in our Ask the Expert style:

https://thesugarscience.org/ask-the-expert/

Episode 82: Elliot Botvinick, PhD, UCI

Thu, 03 Jun 2021 09:00:00 -0700

In this episode, Dr. Elliot Botvinick joins us to talk about his work with multi-analyte sensing and insulin infusion at UCI. Tune in to hear about iGLOBE.

This episode is in our Ask the Expert style:

https://thesugarscience.org/ask-the-expert/

Episode 81: Andrew Wang, MD, Kin Man Au, PhD, Roland Tisch, PhD, University of North CarolinaW

Thu, 27 May 2021 09:00:00 -0700

In this episode, Dr. Andrew Wang, Dr. Kin Man Au, and Dr. Roland Tisch from the University of North Carolina join us to discuss their recent work, including the recent publication, "Immune Checkpoint-Bioengineered Beta Cell Vaccine Reverses Early-Onset Type 1 Diabetes".

Full paper link: https://onlinelibrary.wiley.com/doi/epdf/10.1002/adma.202101253

This episode is in our Ask the Expert style:

https://thesugarscience.org/ask-the-expert/

Episode 80: Jonathan Weissman, PhD, Professor of Biology at MIT

Thu, 13 May 2021 09:00:00 -0700

In this episode, Dr. Jonathan Weissman joins us in our Ask the Expert format to discuss genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.

This episode is in our Ask the Expert style:

https://thesugarscience.org/ask-the-expert/

Episode 79: Rob Screaton, PhD, Associate Professor at The University of Toronto

Mon, 10 May 2021 22:59:30 -0700

In this episode, Rob Screaton joins us to discuss one major question: Can we get adult human beta cells to regenerate?

His lab uses high-throughput functional genomic imaging screens to identify novel players involved in cell signaling pathways that control human pancreatic beta cell proliferation. In addition, we are interested in the function and quality control of mitochondria, critical subcellular organelles essential for cell function and survival.

This episode is in our Ask the Expert style:

https://thesugarscience.org/ask-the-expert/

Episode 78: Avenesh Thakor, MD, PhD, Assistant Professor of Radiology at Stanford University (Re-Release)

Tue, 04 May 2021 10:39:35 -0700

In this episode re-release, Avnesh Thakor joins us to discuss bioscaffolds that are used to support pancreatic islet transplantation. Dr. Thakor's research interests are focused primarily on the pancreas, with respect to regenerative medicine and oncology. In Thakor's lab, they are creating biocompatible 3D structures which contain spaces to accommodate islets. These bioscaffolds will aim to facilitate oxygen generation and angiogenesis, both of which are essential for islet survival and function.

Click on this link to learn more about the lab.

https://med.stanford.edu/thakorlab/Pancreas.html

Episode 77: Matthias Barth, PhD, Leuphana University of Lüneburg in Germany

Thu, 29 Apr 2021 09:00:00 -0700

In this episode, Professor Matthias Barth joins us to discuss his work studying higher education at Leuphana University in Germany. Dr. Barth is one of the steering-group members of the Postdoc Academy for Transformational Leadership, a training programme for researchers in the sustainability field.

Episode 76: David Wagner, PhD, University of Colorado

Thu, 22 Apr 2021 09:00:00 -0700

In this episode, David Wagner joins us to present and answer questions on his work at the University of Colorado and with Op-T-Mune. This episode is in our Ask the Expert style:

https://thesugarscience.org/ask-the-expert/

Episode 75: Eiji Yoshihara, PhD, Principal Investigator, The Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center

Tue, 20 Apr 2021 09:12:41 -0700

In this episode, Eiji Yoshihara joins us to discuss the research taking place at Yoshihara Lab at the Lundquist Institute. The overarching goal of the Yoshihara Lab is to understand the origins of life and physiology through utilizing state-of-the-art biomedical technologies.

Japanese Translation @ minute 25

Learn more about the Yoshihara Lab Here

Episode 74: Toby Coates, PhD, Professor of Medicine at the University of Adelaide

Thu, 15 Apr 2021 09:00:00 -0700

In this episode, Dr. Toby Coates joins us to give us some insights into his work with the Biodegradable Temporizing Matrix (BTM).

Episode 73: Matthieu Raoux, PhD, HDR, Associate Professor, University of Bordeaux, France

Tue, 13 Apr 2021 09:00:00 -0700

In this episode, Matthieu Raoux joins us to talk about his fascinating research at the University of Bordeaux, France. Dr. Raoux provides insights to his recent publication: Dynamic Uni- and Multicellular Patterns Encode Biphasic Activity in Pancreatic Islets.

" Our data provide a new uni- and multicellular model of islet β-cell activation: during the 1st phase, small but highly active β-cell clusters are dominant, whereas during the 2nd phase electrical coupling generates large functional clusters via multicellular slow potentials to favor an economic sustained activity."

Checkout his latest publication!

Episode 72: Noel G. Morgan, PhD, Professor of Endocrine Pharmacology and Director of the Institute of Biomedical & Clinical Science at the University of Exeter

Thu, 08 Apr 2021 09:00:00 -0700

In this episode, Professor Noel G. Morgan joins us to discuss his work in cellular pharmacology and studying the pathophysiology of pancreatic beta-cells in diabetes. He also talks about his work with B cells and a recent publication, "Footprints of Immune Cells in the Pancreas in Type 1 Diabetes; to “B” or Not to “B”: Is That Still the Question?".

Link to his paper: https://www.frontiersin.org/articles/10.3389/fendo.2021.617437/full

Episode 71: Alok Joglekar, PhD, Assistant Professor at University of Pittsburgh School of Medicine

Tue, 06 Apr 2021 08:31:58 -0700

In this episode, we speak with Alok Joglekar about his fantastic research at the University of Pittsburg. Dr. Joglekar provides us with some insights to his publication: T cell antigen discovery. T cells play a critical role in the elimination of pathogens and the surveillance of pathological cells.

Read the full text here

Episode 70: Matthias von Herrath, MD, Professor at the La Jolla Institute for Immunology and Vice President and Senior Medical Officer at Novo Nordisk

Thu, 01 Apr 2021 09:00:00 -0700

In this episode, Dr. Matthias von Herrath joins us to discuss his work at the La Jolla Institute for Immunology and at pharmaceutical company Novo Nordisk. He discusses one of his recently published papers, "Anti-interleukin-21 antibody and liraglutide for the preservation of β-cell function in adults with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled, phase 2 trial".

Full paper link: https://www.thelancet.com/journals/landia/article/PIIS2213-8587(21)00019-X/fulltext

Episode 69: Hans Sollinger, MD, PhD, Founder & Interim CSO of Endsulin

Tue, 30 Mar 2021 09:00:00 -0700

In this episode, we speak to Dr. Hans Sollinger, MD, PhD, Founder & Interim CSO of Endsulin. Dr. Sollinger has been a leader in diabetes care for decades and has revolutionized the field twice.

Endsulin is overcoming the limitations of today's taxing diabetes treatments with a patented gene construct and simple process that re-engineers part of the liver, allowing it to produce and regulate insulin on its own.

Learn more about Endsulin here!

Episode 68: Burcak Yesildag, PhD, Head of Islet Solutions at InSphero

Thu, 25 Mar 2021 09:00:00 -0700

In this episode, Burcak Yesildag joins us to discuss her work in the Islet Solutions Group at InSphero, generating advanced and high-throughput compatible assays and disease models for diabetes drug discovery. She also gives us some insight into a recent publication, "Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes".

Full paper: Human Islet Microtissues as an In Vitro and an In Vivo Model System for Diabetes

To learn more about InSphero: https://insphero.com/

Episode 67: Arun Sridhar, PhD, Co- Founder Skraps & Philippe Blancou, PhD, Professor at CNRS- Centre National de la Recherche Scientifique

Tue, 23 Mar 2021 09:00:00 -0700

In this episode, Arun Sridhar and Philippe Blancou join us to discuss their innovative work in the type 1 diabetes space. These researchers provide us details about one of their recent publications: Pancreatic nerve electrostimulation inhibits recent-onset autoimmune diabetes.

Arun Sridhar is the host of Skraps, a top 10% rated scientific podcast. Tune in to listen to stories of scientific brilliance!

Episode 66: Ying Liu, PhD, and graduate students Paola Leon Plata and Maryam Zaroudi from University of Illinois at Chicago

Thu, 18 Mar 2021 09:00:00 -0700

In this episode, Dr. Ying Liu along with PhD students Paola Leon Plata and Maryam Zaroudi join us to talk about their recent publication, "Heterogeneous Toroidal Spiral Particles for Islet Encapsulation". Liu Laboratory at the University of Illinois Chicago Department of Chemical Engineering focuses on nano- and micro- materials to address current challenges in drug delivery and tissue engineering.

Click here for the full paper, and here to learn more about Liu Laboratory.

Episode 65: Laia Gómez Muñoz, PhD student in Immunology, Germans Trias i Pujol Research Institute (IGTP)

Tue, 16 Mar 2021 09:00:00 -0700

In this episode, Laia Gómez Muñoz joins us to discuss her recent publication, NK Cell Subsets Changes in Partial Remission and Early Stages of Pediatric Type 1 Diabetes.

Laia is a PhD student at the Immunology of Diabetes Group under the supervision of Dra. Marta Vives. Her research focuses on the identification of new biomarkers of partial remission in pediatric patients with autoimmune diabetes for their application in immunological monitoring and clinical trials.

Episode 64: Emily Sims, MD, Pediatric Endocrinologist and Assistant Professor of Pediatrics at Indiana University

Thu, 11 Mar 2021 09:00:00 -0800

In this episode, Dr. Emily Sims joins us to discuss her research focused on diabetes risk factors and treatments to predict or slow diabetes progression. Tune in to learn more about her recent publication on teplizumab, titled "Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals".

Click here to read the full paper.

Episode 63: Alex Cogdill, PhD, Director of Business Development and Corporate Strategy at Immunai

Tue, 09 Mar 2021 09:00:00 -0800

In this episode, Alex Cogdill joins us to discuss Immunai. Immunai is an innovative biotech company that works with partners to discover and develop therapies through the integration of machine learning and single-cell multimodal omics at scale. Dr. Cogdill has 13 years of experience in drug discovery and research management; having published >50 scientific articles in the immuno-oncology space with >9,000 citations

Learn more about Immunai here

Episode 62: Wendy Wolf, PhD, VP of Registry and Research at T1D Exchange

Thu, 04 Mar 2021 09:00:00 -0800

In this episode, Wendy Wolf joins us to talk about T1D Exchange and the work they are doing to improve T1D research. T1D Exchange strives to improve outcomes for the T1D population by driving real-world evidence and collaborative change. Their Registry is a long-term research study where individuals volunteer their data to contribute to research evidence.

Learn more about T1D Exchange here, and the Registry here.

Episode 61: Peter Senior, PhD, Endocrinologist & Professor at University of Alberta and Kate Farnsworth, Patient Partner at Diabetes Action Canada

Tue, 02 Mar 2021 09:00:00 -0800

In this episode, Peter Senior and Kate Farnsworth join us to discuss the exciting work taking place at Diabetes Action Canada. Diabetes Action Canada recently launched Connect1d. This platform allows those living with T1D to contribute to research in areas that matter most to them, while also allowing researchers to engage with a diverse range of people living with T1D from across Canada.

Interested in learning more about Connect1d?

Visit their website.

Episode 60: José García-Tirado, PhD, Research Associate at the University of Virginia Center for Diabetes Technology

Thu, 25 Feb 2021 09:00:00 -0800

In this episode, Dr. José García-Tirado joins us to discuss his work with the individualization of behavior patterns (including eating and exercise patterns) from CGM, insulin pump, and activity tracker data.

Click on the links below for some of his recent papers.

Mapping data to virtual patients in type 1 diabetes

Anticipation of Historical Exercise Patterns by a Novel Artificial Pancreas System Reduces Hypoglycemia During and After Moderate-Intensity Physical Activity in People with Type 1 Diabetes

Episode 59: Amelia Linnemann, PhD, Assistant Professor at Indiana University School of Medicine

Tue, 23 Feb 2021 09:00:00 -0800

In this episode, Amelia Linnemann joins us to speak about the mechanisms of adaptive stress response in the pancreatic islet. Dr. Linnemann provides us with some insight about a recent publication, Pancreatic beta cell autophagy is impaired in type 1 diabetes.

Learn more about her work here

Episode 58: Qiufu Ma, PhD, Professor of Neurobiology at Harvard University, Dana-Farber Cancer Institute

Tue, 16 Feb 2021 09:00:00 -0800

In this episode, Qiufu Ma joins us to discuss the ongoing research taking place in his lab. Dr. Ma's lab focuses on two lines of research: mapping pain pathways and exploring how acupuncture works. Tune in to hear Dr. Ma discuss one of his recent publications, Somato-Autonomic Reflexes of Acupuncture.

Learn more about Ma Lab here

Episode 57: Gaël McGill, PhD, Founder & CEO at Digizyme, Professor at Harvard Medical School

Thu, 11 Feb 2021 09:00:00 -0800

In this episode, Gaël McGill joins us to discuss ways in which cell and molecular visualization can inform the research and discovery process. Dr. McGill is the founder of Digizyme. Digizyme's mission is to innovate at the intersection of science, technology, art and learning to create accurate and effective visual context for understanding science.

Follow the link below for an animation video that explains the fundamentals of SARS CoV-2 membrane binding.

SARS CoV-2 animation

To learn more about Digizyme, click here

Episode 56: David Wraith, PhD, Professor of Immunology, Director of the Institute of Immunology and Immunotherapy, University of Birmingham

Tue, 09 Feb 2021 09:00:00 -0800

In this episode, David Wraith joins us to discuss his profound knowledge on autoimmunity and immunotherapy. His research team has revealed mechanisms whereby autoreactive T-cells escape deletion in the thymus and thus appear in the repertoire of all individuals. He also demonstrated that autoreactive T-cells can be silenced by suitable administration of fragments of their protein targets.

Episode 55: Jessica Gibson, MBA, CEO and Co-Founder of Ariel Precision Medicine

Thu, 04 Feb 2021 09:00:00 -0800

In this episode, Jessica Gibson joins us to discuss the latest work at Ariel Precision Medicine. Ariel is a health technology company seamlessly integrating complex genetics into clinical decision-making, empowering doctors and patients to prevent, mitigate or even reverse disease progression. Ariel's initial focus is pancreatic diseases including pancreatitis, diabetes and pancreatic cancer.

Learn more about Ariel Precision Medicine here

Episode 54: Josh Nicholson, PhD, Co-Founder and CEO at Scite

Tue, 02 Feb 2021 09:00:00 -0800

In this episode, Josh Nicholson joins us to discuss how to use Scite. Scite is a deep learning platform that evaluates the reliability of scientific claims by citation analysis. Scite is a very valuable tool for all researchers.

Smart citations for better research.

Checkout scite here!

Episode 53: Bart Roep, PhD, Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes, Director, The Wanek Family Project for Type 1 Diabetes

Thu, 28 Jan 2021 09:00:00 -0800

In this episode, Bart Roep joins us to discuss the latest progress at City of Hope in the quest to cure type 1 diabetes. Early 2020 marked a milestone for science funded by The Wanek Family Project. Results had come in from a first-in-humans clinical trial testing a “reverse vaccine” for type 1 diabetes developed by Roep and his colleagues. The research showed the treatment to be safe and even indicated possible benefit as a therapy.

Episode 52: Scott Soleimanpour, MD, Associate Professor, Director of the Michigan Medicine Diabetes Transition Program, University of Michigan

Tue, 26 Jan 2021 09:00:00 -0800

In this episode, Scott Soleimanpour joins us to discuss his fascinating research taking place at the University of Michigan. Dr. Soleimanpour provides details about a recent publication, Mitophagy protects β cells from inflammatory damage in diabetes.

Dr. Soleimanpour's lab focuses on the molecular and genetic regulation of the mitochondrial life cycle, with a focus on mitophagy, a pathway to dispose of unhealthy or damaged mitochondria. Our studies also concentrate on novel genetic targets affecting the mitophagy pathway, which are also associated with diabetes in humans, through studies in cellular and mouse genetic model systems, as well as isolated human islets.

To learn more about Soleimanpour's lab follow the link below:

Soleimanpour Lab

Episode 51: Darleen Sandoval, PhD, Professor at the University of Colorado

Thu, 21 Jan 2021 09:00:00 -0800

In this episode, Darleen Sandoval joins us to discuss her research and recent publication, Updating the Role of α-Cell Preproglucagon Products on GLP-1 Receptor–Mediated Insulin Secretion.

Dr. Sandoval's current work utilizes basic research strategies to focus on two general themes of research. The first goal is to gain understanding on the role of a gastrointestinal peptide, GLP-1, in the gut-brain axis to regulate energy and glucose homeostasis. The second is to gain understanding on the adaptations of the gut-brain axis with bariatric surgery and how this leads to the profound weight-loss and improvements in glucose and lipid homeostasis seen with these surgeries.

Episode 50: Ed Boyden, PhD, Y. Eva Tan Professor in Neurotechnology at MIT Howard Hughes Medical Institute

Tue, 19 Jan 2021 09:00:00 -0800

In this episode, Ed Boyden joins us to discuss his research at MIT and how an imaging technology developed by Boyden and his colleagues is applicable to type 1 diabetes researchers. Dr. Boyden leads the Synthetic Neurobiology Group, which develops tools for analyzing and repairing complex biological systems such as the brain, and applies them systematically to reveal ground truth principles of biological function as well as to repair these systems. He co-directs the MIT Center for Neurobiological Engineering, which aims to develop new tools to accelerate neuroscience progress, and is a faculty member of the MIT Center for Environmental Health Sciences, Computational & Systems Biology Initiative, and Koch Institute.

To learn more about Dr. Boyden's research follow the link below:

Synthetic Neurobiology Group

Episode 49: Dame Frances Ashcroft, PhD, Royal Society GlaxoSmithKline Research Professor at the University Laboratory of Physiology, Oxford

Thu, 14 Jan 2021 09:00:00 -0800

In this episode, Dame Frances Ashcroft joins us to discuss her research and recent publication titled, Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells.

Dr. Frances Ashcroft's research focuses on ATP-sensitive potassium (KATP) channels and their role in insulin secretion, in both health and disease. To learn more about her research visit her website below.

Ashcroft Group

Photographer: Robert Taylor

Episode 48: Teresa Rodriguez-Calvo, DVM, PhD, Junior Group Leader in the Type 1 Diabetes Pathology Research Unit, Institute of Diabetes Research, Helmholtz Zentrum München

Tue, 12 Jan 2021 09:15:32 -0800

In this episode, Teresa Rodriguez-Calvo joins us to discuss her type 1 diabetes research at the International Helmholtz Research School for Diabetes. Dr Rodriguez-Calvo is interested in the crosstalk between the immune system and the cells that produce insulin, called beta cells. We are working on identifying the cells that recognize different beta cell antigens and their exact localization in the pancreas, spleen, lymph nodes and duodenum, in order to better understand the pathogenesis of the disease. We are also trying to elucidate whether viral infections make the islets more accessible for these destructive T cells or vice versa.

To read some of her recent publications follow the link below:

Dr. Rodriguez-Calvo's Publications

Episode 47: Susan Wong, PhD, Professor of Experimental Diabetes and Metabolism, Division of Infection and Immunity, Systems Immunity URI, Cardiff University, UK

Thu, 07 Jan 2021 11:37:25 -0800

In this episode, Susan Wong joins us to discuss her years of research experience working on the aetiology and pathogenesis of type 1 diabetes. Dr. Wong also discusses one of her recent publications, Slow progressors to type 1 diabetes lose islet autoantibodies over time, have few islet antigen-specific CD8+ T cells and exhibit a distinct CD95hi B cell phenotype.

Follow the link below to read more about Dr. Wong's work:

Dr. Wong's publications

Episode 46: Francisco Leon, MD, PhD, Chief Scientific Officer & Co-Founder of Provention Bio

Tue, 22 Dec 2020 07:50:00 -0800

In this episode, Francisco Leon joins us to discuss how he became scientifically interested in type 1 diabetes and what led him to where he is today. Dr. Leon is the CSO and Co-Founder of Provention Bio. Provention Bio's mission is to change the world by unleashing the full potential of lives otherwise burdened of cut short by autoimmune disease.

Provention Bio has an exciting pipeline of investigational candidates that aim to intercept type 1 diabetes by delaying or even preventing progression to clinical onset of insulin dependent T1D.

Episode 45: Yong Zhao, MD, PhD, President of Tianhe Stem Cell Biotechnologies Inc

Thu, 17 Dec 2020 07:50:00 -0800

In this episode, Yong Zhao joins us to discuss Tianhe Stem Cell Biotechnologies Inc. and the progress of clinical trials using the stem cell educator. Tianhe’s notable Stem Cell Educator Therapy was invented by Dr. Yong Zhao to effectively reverse the root causes of autoimmune diseases. Over the last 10 years, international multi-center clinical studies in the United States, China, and Spain have demonstrated the clinical safety and efficacy of Stem Cell Educator Therapy as it has been recognized by the Juvenile Diabetes Cure Alliance as one of the top 10 “Practical Cure Projects” for type 1 diabetes (State of the Cure, 2018)

Tianhe Stem Cell Biotechnologies

Episode 44: Julie Sneddon, PhD, Assistant Professor, UCSF School of Medicine

Tue, 15 Dec 2020 09:10:19 -0800

In this episode, Julie Sneddon joins us to discuss exciting type 1 diabetes research taking place in her lab. Dr. Sneddon’s laboratory studies the underlying biology of the cellular microenvironment, including the cellular diversity and lineage relationships of the non-epithelial compartment of the pancreas in the context of organogenesis, adult organ function, and disease. Recently, Dr. Sneddon was just awarded the Helmholtz Young Investigator in Diabetes (HeIDi) award.

Visit Dr. Sneddon's Lab Website

Episode 43: Emrah Altindis, PhD, Assistant Professor, Boston College

Mon, 14 Dec 2020 12:02:24 -0800

In this episode, Emrah Altindis joins us to discuss his excellent publication, Parabacteroides distasonis insulin B:9-23 epitope mimic stimulates insulin specific T-cells and enhances type 1 diabetes in NOD mice. The main goal of Dr. Altindis' lab is to better understand the role of microbial mimicry mechanisms in human diseases and characterize these microbial proteins. In addition to the potential effects on metabolism and physiology of the host, these microbial mimickers have the potential to cause autoimmune diseases, including type 1 diabetes.

Altindis Lab

Episode 42: Roland Eils, PhD, Director for Digital Health at Berlin Institute of Health, and Luca Tosti, PhD, Postdoctoral Fellow at Berlin Institute of Health

Thu, 10 Dec 2020 07:45:00 -0800

In this episode, Roland Eils and Luca Tosti join us to discuss their research in the type 1 diabetes space. Scientists from the BIH are coordinating an international project on the single-cell analysis of the human pancreas. The project is part of a global project- known as the Human Cell Atlas. Dr. Eils and Dr. Tosti provide us with information about the Human Cell Atlas.

Episode 41: Per-Ola Carlsson, MD, PhD, Professor of Medical Cell Biology, Sr. Consultant in Endocrinology and Diabetology at Uppsala Hospital

Tue, 08 Dec 2020 07:30:00 -0800

In this episode, Per-Ola Carlsson joins us to discuss his latest research. Dr. Carlsson's work focuses on developing means to intervene with the development of type 1 diabetes mellitus and find treatment strategies to restore glucose homeostasis in patients with type 1 using cell therapy.

Want to read more about his work? Checkout a recent publication, Better HbA1c during the first years after diagnosis of type 1 diabetes is associated with residual C peptide 10 years later

Episode 40: Reena Singh, PhD, Research Fellow at The University of Sydney, Australia

Thu, 03 Dec 2020 07:45:00 -0800

In this episode, Reena Singh joins us to discuss her research and one of her recent publications titled, Enhanced Structure and Function of Stem Cell-Derived Beta-Like Cells Cultured on Extracellular Matrix. Dr. Singh is a developmental and stem cell biologist and her current area of research is to develop cell replacement therapy for people living with type 1 diabetes. Dr. Singh is working towards understanding the effect of beta cell niche on its structure and function and modifying the microenvironment to augment stem cell derived-beta cell function.

To learn more about Dr. Singh's and colleagues research visit Thorn's Lab website.

Episode 39: vLUME, 3D Nanoimaging Platform, Alex Kitching, Alex Spark, Steven F. Lee, PhD

Tue, 01 Dec 2020 07:45:00 -0800

In this episode, Alex Kitching, Alex Spark, and Steven Lee join us to discuss vLUME technology, 3D Nanoimaging Platform and how it is applicable to type 1 diabetes researchers. vLUME is the world's first and only Virtual Reality solution for Super-resolution Microscopy.

Visualise, segment, and analyse in real-time your massive localization data at any scale.

Click the following link for a live demo of the technology:

Live Demo- Helper T Cell

Episode 38: Jacob Hecksher-Sørensen, Principal Scientist at Gubra, Imaging Diabetes Using Light Sheet Microscopy

Mon, 30 Nov 2020 07:45:00 -0800

In this episode, Jacob Hecksher-Sørensen joins us to discuss imaging diabetes using light sheet microscopy. Jacob walks us through some of the advantages of using this technology and provides us with a live demonstration from two previous experiments.

Checkout the full live demonstration following the link below:

https://youtu.be/TmbXq5F_41w

Want to learn more about his published work? Follow the link below:

3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II

Episode 37: Madina Makhmutova, PhD, Postdoctoral Research Associate at University of Miami, Miller School of Medicine

Thu, 19 Nov 2020 08:53:40 -0800

In this episode, Madina Makhmutova joins us to discuss her recent publication, Pancreatic beta cells communicate with vagal sensory neurons. Her research findings may have important implications for type 1 diabetes researchers.

To learn more about Dr. Makhmutova's research in the Islet-Caicedo Lab follow the link below:

Islet-Caicedo Lab

Episode 36: Andrew Sas, MD, PhD, Assistant Professor at Ohio State University Wexner Medical Center

Tue, 17 Nov 2020 07:45:00 -0800

In this episode, Andrew Sas joins us to discus his recent publication, A new neutrophil subset promotes CNS neuron survival and axon regeneration. Dr. Sas also discusses ongoing research in his lab and how the neutrophil may have the potential to mediate inflammation in other areas of the body, such as the pancreatic beta call under autoimmune attack in type 1 diabetes.

Listen to this episode to gain new insight and help address some important questions that were brought up and need further investigation.

Episode 35: Calvin Carter, PhD, Sunny Huang, MD/PhD candidate, Co-Founders of Geminii Health

Mon, 09 Nov 2020 14:54:30 -0800

In this episode, Calvin Carter and Sunny Huang join Monica Westley to discuss their new findings published Oct. 6 in Cell Metabolism, Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes, and new venture Geminii Health. Geminii Health is a medical device company that is pioneering a new wave of medicines and are building the NuWave, a wearable remote control to manage blood sugar.

Listen in as Dr. Carter and Dr. Huang discuss the pure serendipity of their findings.

Want to read more? Follow the link below:

Remote control of blood sugar: Electromagnetic fields treat diabetes in animal models

Episode 34: Avnesh Thakor, MD, PhD, Assistant Professor of Radiology at Stanford University Medical Center

Fri, 06 Nov 2020 12:11:59 -0800

In this episode, Avnesh Thakor joins Sajeev Saluja to discuss bioscaffolds that are used to support pancreatic islet transplantation. Dr. Thakor's research interests are focused primarily on the pancreas, with respect to regenerative medicine and oncology. In Thakor's lab they are creating biocompatible 3D structures which contain spaces to accommodate islets. These bioscaffolds will aim to facilitate oxygen generation and angiogenesis, both of which are essential for islet survival and function.

To learn more about his research in the lab follow the link below.

Thakor Lab

Episode 33: Tiffany Richardson, PhD candidate, Vanderbilt University School of Medicine

Wed, 04 Nov 2020 08:00:00 -0800

In this episode, Tiffany Richardson joins Monica Westley to discuss her ongoing research in the Powers-Brissova Research Group. Richardson's research focuses on elucidating the innervation landscape within the exocrine and endocrine portions of the pancreas.

Want to read more about Richardson's work? Follow the links below.

Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration

2140-P: Pancreatic Islet and Exocrine Tissue Innervation Is Not Altered in Type 1 Diabetes

Episode 32: Alexandra Smink, PhD, University Medical Center Groningen (UMCG)

Mon, 02 Nov 2020 08:00:00 -0800

In this episode, Alexandra Smink joins Monica Westley to discuss her research in the type 1 diabetes space. Dr. Smink's research focuses on polymer scaffolds for pancreatic islet transplantation. In 2018, Dr. Smink was awarded the young investigator JDRF award and most recently was awarded the EASD Rising Star Award.

Using so-called extracellular matrix, which can be used to wrap the islets up and, thus, protect them from the outside world where the immune system lurks, Dr Smink from the Netherlands has designed a device capable of communicating with this outside world but doing so safely, in order to get the nutrients, oxygen and other molecules that the islets need to survive.

Episode 31: Patrick MacDonald, PhD, & Jasmine Maghera, University of Alberta

Fri, 30 Oct 2020 09:00:00 -0700

In this episode, Patrick MacDonald and Jasmine Maghera join Monica Westley to discuss the ongoing research in Dr. Patrick's laboratory. Some exciting new directions in the laboratory include islet-cell phenotyping by combined patch-clamp and single-cell sequencing; and computational modelling of human islet cell profiles.

To learn more about MacDonald Islet Biology Laboratory, click the link below.

MacDonald Islet Biology Laboratory

Episode 30: Lonnie Shea, PhD, William and Valerie Hall Chair, Biomedical Engineering Steven A. Goldstein Collegiate Professor at University of Michigan

Wed, 28 Oct 2020 09:00:00 -0700

In this episode, Lonnie Shea joins Monica Westley to discuss the intersection of regenerative medicine, immune engineering, precision health and type 1 diabetes. Dr. Shea's projects include islet transplantation for diabetes therapy and nerve regeneration for treating paralysis.

To learn more about the ongoing research taking place at The Shea Lab, click on the link below.

The Shea Lab

Episode 29: Adam Ramzy, MD/PhD Candidate at the University of British Columbia

Tue, 27 Oct 2020 09:00:00 -0700

In this episode, Adam Ramzy joins Monica Westley to discuss his recent publication, Revisiting proinsulin processing: evidence that human β-cells process proinsulin with prohormone convertase (PC) 1/3 but not PC2. Adam's research projects include investigating prohormone processing and developing gene and cell based therapies for diabetes in the lab of Dr. Timothy Kieffer.

To learn more about The Kieffer Lab, click on the link below.

The Kieffer Lab

Episode 28: Adebola Giwa, MD, Pediatric Endocrinologist at Johns Hopkins Children’s Center

Mon, 26 Oct 2020 10:37:04 -0700

In this episode, Adebola Giwa joins Monica Westley to discuss his bench and clinical research in the type 1 diabetes space. Dr. Giwa is a research investigator in The Hamad Laboratory. His bench research is focused on identifying unconventional lymphocytes and studying their role in the pathogenesis of type 1 diabetes to possibly target them for future immunotherapies. His clinical research involves multi-center clinical trials utilizing islet cell transplants to reestablished insulin production and other beta cell function in people with established type 1 diabetes.

Checkout his recent publication:

Current understandings of the pathogenesis of type 1 diabetes: Genetics to environment

Episode 27: Daniel Espes, MD, PhD, Associate Professor at Uppsala Universitet, Sweden, Co-Founder of Digital Diabetes Analytics

Fri, 23 Oct 2020 09:14:54 -0700

In this episode, Daniel Espes joins Monica Westley to discuss his work and dedication to type 1 diabetes research. Dr. Espes is the co-founder of Digital Diabetes Analytics. The mission of Digital Diabetes Analytics is to create a bridge between diabetes data and knowledge in order to make life more flexible for everyone living with insulin treated diabetes.

Interested in learning more about Dr. Espes work?

Take a look at some of his recent data: ProTrans shows significant effect in Diabetes

Episode 26: Lucy Walker, PhD, University College London, The Walker Lab

Thu, 22 Oct 2020 22:47:30 -0700

In this episode, Lucy Walker joins Monica Westley to discuss her research at the Walker Lab at the University College London. The group is exploring how CD4 T cell mediated immune responses are initiated and regulated. The principle research goal is to understand why immune regulation fails in certain individuals resulting in destructive autoimmune responses against self-tissues.

To learn more about the Walker Lab, click on the link below!

The Walker Lab

Recent Publication:

Follicular helper Tcell profiles predict response to costimulation blockade in type 1 diabetes

Episode 25: Eimear Dolan, PhD, SFI Royal Society University Research Fellow and Lecturer Biomedical Engineering, National University of Ireland Galway

Wed, 21 Oct 2020 08:00:00 -0700

In this episode, Eimear Dolan joins Monica Westley to discuss her work with implantable medical devices for treating type 1 diabetes. In the interview she also provides some great advice for researchers.

Dr. Dolan has recently been named as one of 10 global visionaries in MIT Technology Review's annual list of Innovators Under 35. Dolan and colleagues have developed a soft robotic device known as a dynamic soft reservoir to improve the longterm performance of implanted medical devices.

Episode 24: Christine Bender, PhD, La Jolla Institute for Immunology

Tue, 20 Oct 2020 18:37:16 -0700

In this episode, Christine Bender joins Monica Westley to discuss her latest research at the La Jolla Institute for Immunology in the Von Herrath Laboratory. Her major project focuses on study antigen-specific CD8 T cells, in pancreas from donors with type 1 diabetes and healthy donors.

Make sure to look out for her new publication coming out soon in Science Advances in October.

Want to read more about her research? Checkout the following paper linked below.

Islet-Expressed CXCL10 Promotes Autoimmune Destruction of Islet Isografts in Mice With Type 1 Diabetes

Episode 23: Inish O'Doherty, PhD, Executive Director, Type 1 Diabetes (T1D) and Transplant Therapeutics (TTC) Consortium at C-Path

Mon, 12 Oct 2020 15:46:27 -0700

In this episode, Inish O'Doherty joins Monica Westley to discuss his work which focuses on the collaborative selection and development of prognostic biomarkers that can be qualified as Drug Development Tools (DDT) and Novel Methodologies with the FDA and EMA, respectively. Dr. O'Doherty is the Executive Director of C-Path’s Type 1 Diabetes (T1D) and Transplant Therapeutic Consortium (TTC).

To learn more about the ongoing research at C-Path, click on the link below

C-Path Website

Episode 22: Edward Phelps, PhD, Assistant Professor, University of Florida

Thu, 08 Oct 2020 14:08:47 -0700

In this episode, Edward Phelps joins Monica Westley to discuss the ongoing research in his laboratory at the University of Florida. Dr. Phelps’s research focuses on biomaterials engineering as a strategy for regenerative therapies with emphasis in the area of type 1 diabetes. The primary focus of the lab is the pancreatic islets of Langerhans and their diseases with an emphasis on beta cell dysfunction and autoimmunity in type 1 diabetes.

To learn more about research at Phelps Laboratory click on the link below.

Phelps Laboratory

Episode 21: Senta Georgia, PhD, Assistant Professor of Pediatrics, Keck School of Medicine of USC

Mon, 05 Oct 2020 16:19:36 -0700

In this episode, Senta Georgia joins Monica Westley to discuss her research at USC. Dr. Georgia's research involves the regeneration of insulin-producing, pancreatic beta cells as a potential therapeutic for patients with type 1 diabetes. Her research on how the enzyme, DNMT1, is critical to stem cells differentiating into pancreatic beta cells was featured on the cover of the journal Genes & Development.

To learn more about Dr. Georgia's research and the ongoing research in her lab click on the link below.

Georgia Lab

Episode 20: Peter Thompson, PhD, Assistant Professor, University of Manitoba

Wed, 30 Sep 2020 12:59:58 -0700

In this episode, Peter Thompson joins Monica Westley to discuss his research in the type 1 diabetes space. Dr. Thompson is an Assistant Professor at the University of Manitoba and his research focuses on investigating cellular and molecular mechanisms operating in pancreatic beta cells to understand how and why this disease occurs.

Dr. Thompson- "There is some really exciting work coming out, particularly with relevance to the roll of the beta cell in type 1. In particular, it is really becoming clear that beta cells are not simply dying in type 1, they are becoming dysfunctional. This really opens up a whole new avenue to explore."

Episode 19: Ekaterine Berishvili MD, PhD, Senior Scientist at University of Geneva

Mon, 28 Sep 2020 15:33:49 -0700

In this episode, Ekaterine Berishvili joins Monica Westley to discuss her research at the University of Geneva. Dr. Berishvili's research is currently focused on the bioengineering of vascularized and immune-protected bioartificial pancreas that can be transplanted into non-immunosuppressed patients.

Interested in learning more about Dr. Berishvili's research? Clink on the link below for one of her recent publications.

Immunomodulatory Properties of Amniotic Membrane Derivatives and Their Potential in Regenerative Medicine

Episode 18: Kevin Otto, PhD, Professor at University of Florida

Wed, 23 Sep 2020 08:55:40 -0700

In this episode, Kevin Otto joins Monica Westley to discuss his research at The Neuroprostheses Research Lab at the University of Florida. Dr. Otto's research focuses on engineering neural interfaces for both research purposes as well as treatment options in neurological injuries or disease.

Dr. Otto- "Eventual reinnervation can definitely lead to regeneration if the end target has a regeneration capability and so I think that there is a lot of intriguing harmony in that overall thinking. Innervation not only provides some input and provides a lot of output, but it also provides an addressing link- a reason to go forward."

Episode 17: Alejandro Caicedo, PhD, Professor of Medicine, University of Miami Miller School of Medicine

Thu, 10 Sep 2020 14:05:47 -0700

In this episode, Alejandro Caicedo joins Monica Westley to discuss his research in the type 1 diabetes space. Dr. Caicedo's research focuses on the biology of human islets and how the islets interact with the environment.

Interested in learning more about Dr. Caicedo's research?

Checkout the following published articles:

1) The Local Paracrine Actions of the Pancreatic α-Cell

2) Secretory Functions of Macrophages in the Human Pancreatic Islet Are Regulated by Endogenous Purinergic Signaling

3) Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point

4) The Pericyte of the Pancreatic Islet Regulates Capillary Diameter and Local Blood Flow

Episode 16: Giuseppe Orlando, MD, PhD, Marie Curie Fellow, Associate Professor at the Wake Forest University School of Medicine

Thu, 10 Sep 2020 09:00:00 -0700

In this episode, Dr. Giuseppe Orlando joins Monica Westley to discuss his interest in type 1 diabetes and strategies for pancreas transplantation. Dr. Orlando is a kidney and pancreas transplant surgeon at the Wake Forest University School of Medicine.

Dr. Orlando- "The problem of using the whole pancreas as a scaffold actually entails the same problems that full organ bioengineering puts us in front of. Which is that we can't replicate the vasculature of an organ. Research is shifting towards to a different approach, you still decellularize the whole organ but then you chop the organ and convert the extracellular matrix into a hydrogel."

Episode 15: Antonio Citro, PhD, Project Leader of Pancreas by Engineering at the Diabetes Research Institute (DRI), Milan

Fri, 04 Sep 2020 10:05:10 -0700

In this episode, Antonio Citro joins Monica Westley to discuss his research at the Diabetes Research Institute in Milan, Italy. Dr. Citro provides insights to his journey as a researcher and what he is currently working on in the type 1 diabetes space.

Dr. Citro- "I think a possible solution to protecting the newly implanted islet is gene editing or the modulation of the scaffold."

Episode 14: Giorgio Raimondi, PhD, Assistant Professor at Johns Hopkins University

Thu, 03 Sep 2020 09:00:00 -0700

In this episode, Giorgio Raimondi joins Monica Westley to discuss his research at Johns Hopkins University in the Vascularized and Composite Allotransplantation Laboratory. Dr. Raimondi provides insights to his recently published work titled: "Multiphase Assembly of Small Molecule Microcrystalline Peptide Hydrogel Allows Immunomodulatory Combination Therapy for Long‐Term Heart Transplant Survival."

Dr. Raimondi- "I am a strong supporter of multidisciplinary approaches. The idea is to try to merge and bring together what is out there so we can give a better life to transplant patients."

Episode 13: Dan Abebayehu, PhD, University of Virginia, The intersection between fibrosis and type 1 diabetes

Tue, 01 Sep 2020 09:00:00 -0700

In this episode, Dan Abebayehu joins Monica Westley to discuss his research in the matrix biology and engineering lab at University of Virginia. His work focuses on examining the role innate immunity plays in initiating fibrosis.

Dr. Abebayehu- "Fibrosis emerges across multiple diseases and is often times one of the key obstacles to developing better therapies."

Episode 12: Bart Roep, PhD, Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes, Founding Chair of the department of Diabetes Immunology at City of Hope

Fri, 28 Aug 2020 15:43:40 -0700

In this episode, Bart Roep joins Monica Westley to discuss the current and future scientific work in the field of type 1 diabetes. Dr. Roep is the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes and the founding chair of the Department of Diabetes Immunology within the Diabetes & Metabolism Research Institute at City of Hope. He serves as project director for The Wanek Family Project for type 1 diabetes at City of Hope, an ambitious initiative committed to developing a cure for type 1 diabetes.

Dr. Roep- "Immunotherapy isn't going to be good enough, we need to have beta cell therapy on top. That will be the perfect storm to treat type 1 diabetes."

Episode 11: Jeffrey Millman, PhD, Assistant Professor at Washington University, Production of pancreatic insulin-producing β cells

Thu, 27 Aug 2020 10:07:42 -0700

In this episode, Jeffrey Millman joins Monica Westley to discuss his research. The major focus of the Millman laboratory is the in vitro production and study of pancreatic insulin-producing β cells from human pluripotent stem cells for use in cellular replacement therapy and drug screening.

Dr. Millman- "The field right now is very hot and exciting! With the development and discovery of how to make insulin-producing β cells from stem cells that I and my colleagues developed when I was working in Doug Melton's lab at Harvard University has opened up a new era of research in diabetes."

Episode 10: Paul-Peter Tak, Academic, business leader and biotech entrepreneur

Wed, 26 Aug 2020 09:00:00 -0700

In this episode, Paul-Peter Tak joins Monica Westley to discuss his innovative ideas within the type 1 diabetes space and how immunology can play a role in helping find a cure for T1D. Paul-Peter is an immunologist, academic, and venture partner who has specialized in the fields of rheumatology and immunology.

Paul-Peter Tak- "I think the future is clearly in looking at type 1 diabetes in a different way. I would almost reclassify it (as an immunologist, not necessarily as a diabetes expert) and I would call it pancreatic autoimmunity."

Episode 9: Izortze Santin Gomez, PhD, University of the Basque Country, Spain, icRNA and type 1 diabetes

Tue, 25 Aug 2020 09:00:00 -0700

In this episode, Izortze Santin joins Monica Westley to discuss her research in the type 1 diabetes space. Dr. Gomez is an associate professor at University of the Basque Country and a researcher at BioCruces Health Research Institute.

Episode 8: Ali Cinar, PhD, Director, Engineering center for diabetes research and education, Illinois institute of technology

Mon, 24 Aug 2020 09:00:00 -0700

In this episode, Ali Cinar joins Monica Westley to discuss his research and how he became interested in studying type 1 diabetes. Professor Cinar's research activities are concentrated in three areas: complex adaptive agent-based systems, modeling, simulation and control of biomedical systems, and supervision of manufacturing process operations.

Episode 7: Giovanni Amabile, PhD, CEO of Enthera, Developing first-in-class biologics for type 1 diabetes

Sun, 23 Aug 2020 16:50:59 -0700

In this episode, Giovanni Amabile joins Monica Westley to discuss the future of Enthera. Enthera is a biotech company building a pipeline of first-in-class biologics for several autoimmune conditions, with a focus in type 1 diabetes and inflammatory bowel disease.

Episode 6: Jennifer Bridge, PhD, Bluestone Lab, Anderson Lab, UCSF

Sun, 23 Aug 2020 16:17:26 -0700

In this episode, Jennifer joins Nicole Phillips to discuss her research at UCSF in the Bluestone Lab and Anderson Lab. Jennifer's research focuses on understanding mechanisms regulating T-cell activation and studying an immunosuppressive population of T cells known as Tregs.

Episode 5: Rebecca Vaught, PhD, Co-Founder of Van Heron Labs, Reframing the understanding of organismal and cellular performance

Sun, 23 Aug 2020 14:50:11 -0700

In this episode, Rebecca Vaught joins Monica Westley to discuss her work at Van Heron Labs and its' potential intersection with type 1 diabetes. Van Heron Labs created a novel pipeline that uses genetic analysis to design a customized procedure for optimizing metabolism for a particular organism or cell, maximizing growth and product output.

Episode 4: Zoe Quandt, MD, Bluestone Lab, UCSF

Sun, 23 Aug 2020 14:14:07 -0700

In this episode, Zoe Quandt joins Nicole Phillips to discuss her research in the Bluestone Lab and Anderson Lab at UCSF. Zoe's research focuses on endocrine immune related adverse events following cancer immunotherapy.

Episode 3: Jonny White, PhD, Life with type 1 diabetes

Sun, 23 Aug 2020 12:51:06 -0700

In this episode, Jonny White joins Scott Phillips to discuss life with Type 1 Diabetes. Jonny is a media psychologist who has type 1 diabetes. He has been very influential and active in the T1D world since he was 15.

Episode 2: Lane Desborough, Finessing blood sugar monitoring

Fri, 21 Aug 2020 18:05:08 -0700

In this episode, Lane Desborough joins Sajeev Saluja to discuss finessing blood sugar monitoring. Lane was the cheif engineer for insulin delivery at Medtronic and chief engineer at Bigfoot Biomedical. He is now pursuing a new idea in automated insulin delivery that is currently in stealth mode.

Episode 1: Nayara Leite, PhD, The Melton Lab, Harvard University

Wed, 19 Aug 2020 09:31:15 -0700

In this episode, Nayara Leite joins Nicole Phillips to discuss her research in The Melton Lab at Harvard University. Nayara's research focuses on using induced pluripotent stem cells for type 1 diabetes in vitro modeling and immunoprotection of beta cells.