The Lancet in conversation with

Can semaglutide be used to treat alcohol use disorder?

Sat, 02 May 2026 23:30:00 +0000

The Lancet’s Niall Boyce and Jonathan Pimm, and eBioMedicine’s Kalypso Karastergiou discuss an exciting new potential treatment for alcohol use disorder: semaglutide.

As new research is published in The Lancet, they go behind the headlines with lead author Professor Anders Fink-Jensen to ask what the study showed, and what its implications are for the future of addiction medicine.

Click here to read the full article:

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00305-3/fulltext

Louise Chappell and Na’ama Carlin on Personal Cancer Stories

Tue, 03 Feb 2026 23:00:00 +0000

The uniqueness of each patient is at the heart of this year's World Cancer Day. Each cancer patient has their own hopes, dreams and fears. In this Podcast you will hear from two cancer survivors about their unique experience with cancer and the importance of personalised cancer care not only on their bodies but also on their lives.

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Susannah Stanway on the London Global Cancer Week

Fri, 19 Dec 2025 23:00:00 +0000

In Conversation with The Lancet returns with Dr Susannah Stanway, honorary consultant medical oncologist at the Royal Marsden and honorary clinical senior lecturer in Education at the Institute of Cancer Research, reflecting on London Global Cancer Week 2025. This episode goes beyond event highlights to discuss the need for a global oncology agenda rooted in equity, evidence-based care, and value across care settings. Topics span from geriatric oncology to cardio-oncology, nursing workforce resilience, cancer care in conflict zones, and sustainable health financing, showing how multi-stakeholder collaboration can drive policy and practical improvements, especially in low- and middle-income countries.

Listeners will take away practical steps for action: integrating geriatric assessment and baseline cardiovascular risk checks, strengthening cancer registries and national audits, and pursuing domestic funding for universal health coverage. The discussion highlights the urgency of addressing cancer globally including context specific solutions sensitive to local settings and emphasises prevention, early diagnosis, and accessible treatment as core priorities.

Click here to visit the London Global Cancer week website

Carlos Monteiro, Camila Corvalán, and Phil Baker on Ultra-Processed Foods and Human Health

Tue, 09 Dec 2025 23:00:00 +0000

Ultra-processed foods are on the rise. Despite the emphasis placed on individual responsibility, our deteriorating diets are primarily the result of the sophisticated political tactics of a powerful global ultra-processed food industry. Addressing this urgent threat demands a coordinated response from the global public health community. So argues a 3-paper Series published in The Lancet that examines the evidence, proposes policies to halt and reverse the rise in ultra-processed foods, and illuminates the fundamental political and economic drivers at play. Professor Carlos Monterio, Professor Camila Corvalán, and Professor Phil Baker join host Callam Davidson to discuss this powerful and timely Series.

Click here to visit the series hub: https://www.thelancet.com/series-do/ultra-processed-food

Download the 'Lancet Series on Ultra-Processed Foods and Human Health' infographic here: https://www.thelancet.com/infographics-do/ultra-processed-food-2025

Presented at ASH: the EPCORE FL-1 study on epcoritamab in follicular lymphoma

Sun, 07 Dec 2025 12:00:00 +0000

Franck Morschhauser joins Ben Abbott of The Lancet to discuss the phase 3 EPCORE FL-1 study on epcoritamab, lenalidomide, and rituximab for relapsed or refractory follicular lymphoma, which is being presented at ASH 2025.

Click here to read the full article: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02360-8/fulltext

Presented at ESMO: the HARMONi-6 study on a bispecific antibody therapy for squamous NSCLC

Sun, 19 Oct 2025 14:00:00 +0000

Shun Lu joins Ben Abbott of The Lancet to discuss the phase 3 HARMONi-6 trial of ivonescimab plus chemotherapy as first-line treatment in advanced squamous non-small-cell lung cancer, which is being presented at ESMO 2025.

Click here to read the full article

Presented at ESMO: the POTOMAC study on immunotherapy in non-muscle-invasive bladder cancer

Fri, 17 Oct 2025 12:00:00 +0000

Neal Shore joins Ben Abbott of The Lancet to discuss the phase 3 POTOMAC trial of durvalumab plus BCG in BCG-naïve, high-risk non-muscle-invasive bladder cancer, which is being presented at ESMO 2025.

Click here to read the full article

Stephen Chan on the Lancet Commission on addressing the global hepatocellular carcinoma burden

Mon, 28 Jul 2025 22:00:00 +0000

With the global burden of liver cancer growing, The Lancet has commissioned an international panel of experts to identify strategies to strengthen the prevention, surveillance, diagnosis, and treatment of liver cancer. Stephen Chan joins Ben Abbott of The Lancet to discuss the key messages of the Commission, which is published today on World Hepatitis Day.

Read the full Commission:

https://www.thelancet.com/commissions-do/hepatocellular-carcinoma?dgcid=buzzsprout_icw_podcast_lancethcc25_lancet

Rebecca Fitzgerald on biomarker risk stratification with capsule sponge in the surveillance of Barrett’s oesophagus

Thu, 24 Jul 2025 22:00:00 +0000

Early detection of oesophageal adenocarcinoma improves outcomes. Patients with the precursor lesion, Barrett's oesophagus, are recommended to undergo regular endoscopic surveillance, a process that can be burdensome for patients and health services.

Professor Rebecca Fitzgerald's team have developed a tool that may be able to improve Barrett's surveillance. She joins us to discuss her recent prospective real-world implementation study of capsule sponge risk stratification in Barrett’s oesophagus surveillance in the UK.

Read the full article:

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01021-9/fulltext?dgcid=buzzsprout_icw_podcast_July_25_lancet

ASCO 2025 Debrief

Wed, 11 Jun 2025 10:00:00 +0000

Vania Wisdom, Senior Executive Editor at The Lancet and the journal's Oncology Ambassador, and Katherine Gourd, Acting Deputy Editor at The Lancet Oncology, join Leon Terner to share some of their experiences, impressions and highlights from this year's American Society of Clinical Oncology (ASCO) conference.

If you haven't already, be sure to listen to Vania's pre-ASCO predictions podcast here: https://www.buzzsprout.com/882697/episodes/17233167

Articles discussed in this podcast episode include:

Zanidatamab plus chemotherapy as first-line treatment for patients with HER2-positive advanced gastro-oesophageal adenocarcinoma: primary results of a multicentre, single-arm, phase 2 study:
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(25)00287-6/fulltext?dgcid=buzzsprout_icw_podcast_asco2025_lancet_tlw

Claudin-18 isoform 2-specific CAR T-cell therapy (satri-cel) versus treatment of physician's choice for previously treated advanced gastric or gastro-oesophageal junction cancer (CT041-ST-01): a randomised, open-label, phase 2 trial:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00860-8/fulltext?dgcid=buzzsprout_icw_podcast_asco2025_lancet_tlw

Relacorilant and nab-paclitaxel in patients with platinum-resistant ovarian cancer (ROSELLA): an open-label, randomised, controlled, phase 3 trial:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)01040-2/fulltext?dgcid=buzzsprout_icw_podcast_asco2025_lancet_tlw

#asco2025

Presented at ASCO: the first RCT of CAR T-cell therapy in solid tumours

Sat, 31 May 2025 18:00:00 +0000

Changsong Qi joins Chloe Wilson and Ben Abbott of The Lancet to discuss their recently published phase 2 randomised controlled trial investigating Claudin-18 isoform 2-specific CAR T-cell therapy for previously treated advanced gastric or gastro-oesophageal junction cancer.

Read the full article:

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)00860-8/fulltext?dgcid=buzzsprout_icw_podcast_May_25_lancet

Previewing ASCO 2025

Fri, 30 May 2025 09:00:00 +0000

Vania Wisdom, Senior Executive Editor at The Lancet and the journal's Oncology Ambassador, joins Gavin Cleaver to discuss what's being published at this year's American Society of Clinical Oncology (ASCO) meeting, what she's excited to see at the conference, and why ASCO is so important to the field.

Francis Couturaud on treatment of venous thromboembolism

Fri, 14 Mar 2025 11:00:00 +0000

Francis Couturaud joins Chloe Wilson of The Lancet to discuss the RENOVE trial, which looks at assessing the efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants in patients in whom extended anticoagulation has been indicated.

Read the full paper:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02842-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

Shawn St Peter on appendicectomy versus antibiotics for acute uncomplicated appendicitis in children

Mon, 27 Jan 2025 11:00:00 +0000

This week, we discuss treatment approaches for uncomplicated appendicitis in children following the publication of a trial in our January 18th issue. Lead author Shawn St Peter, general paediatric surgeon and surgeon-in-chief at Children’s Mercy Hospital, Kansas City, spoke with Callam Davidson about the motivation behind the study, key findings, and what the results mean for clinical practice.

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)02420-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

Michael Heneka on passive anti-amyloid β immunotherapy in Alzheimer’s disease

Thu, 09 Jan 2025 23:00:00 +0000

Michael Heneka joins Chloe Wilson and Bea Gomez Perez-Nievas of The Lancet to discuss a therapeutics paper discussing the opportunities and challenges of passive anti-amyloid β immunotherapy in Alzheimer's disease.

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01883-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

Nusrat Husain, Farah Lunat, and Fehmida Motala on postnatal depression in British south Asian women (the ROSHNI-2 trial)

Thu, 31 Oct 2024 23:00:00 +0000

ROSHNI-2 was a multicentre, randomised controlled trial that investigated the efficacy of a culturally adapted, cognitive behavioural therapy-based intervention for postnatal depression in British south Asian women. Joining us to share their expertise and perspectives are chief investigator Professor Nusrat Husain, trial manager Farah Lunat, and service user representative Fehmida Motala.

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01612-X/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

Rasha Al-Lamee and Shayna Chotai on ESC 2024 highlights

Thu, 10 Oct 2024 22:00:00 +0000

Rasha Al-Lamee and Shayna Chotai join Chloe Wilson of The Lancet to discuss ESC Congress 2024 highlights.

The papers featured on this podcast are:

1) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01733-1/fulltext
2) https://www.nejm.org/doi/abs/10.1056/NEJMoa2409134
3) https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01454-5/abstract
4) https://www.nejm.org/doi/abs/10.1056/NEJMoa2314328
5) https://www.escardio.org/Guidelines/Clinical-Practice-Guidelines/Elevated-Blood-Pressure-and-Hypertension
6) https://www.jacc.org/doi/10.1016/j.jacc.2024.08.027

Dr Oriol Mitjà and Dr Hypolite Muhindo Mavoko on mpox

Thu, 05 Sep 2024 22:00:00 +0000

On August 14th, the World Health Organisation declared a public health emergency of international concern in relation to mpox. This was motivated, in part, by the emergence of a concerning new strain of mpox, clade 1b, which has spread rapidly across Central Africa. Joining me this week to discuss important clinical aspects of the current mpox outbreak are Dr Oriol Mitja, Associate Professor at the Germans Trias Research Institute in Barcelona, and Dr Hypolite Muhindo Mavoko from the Department of Tropical Medicine at the University of Kinshasa.

Natasha Pocovi on the prevention of low back pain recurrence

Thu, 08 Aug 2024 22:00:00 +0000

Natasha Pocovi joins Chloe Wilson of The Lancet to discuss a trial investigating a walking and education intervention for the prevention of low back pain recurrence in Australia (WalkBack).

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00755-4?dgcid=buzzsprout_tlv_podcast_generic_lancet

Prasad Kulkarni on a vaccine against typhoid and paratyphoid

Thu, 02 May 2024 22:00:00 +0000

Prasad Kulkarni joins Callam Davidson of The Lancet to discuss the safety and immunogenicity of a bivalent conjugate vaccine against typhoid and paratyphoid, following the publication of a phase 1 trial.

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)00249-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

Patricia Campbell and Frans Rutten on heart failure with preserved ejection fraction

Thu, 28 Mar 2024 23:00:00 +0000

Patricia Campbell and Frans Rutten join Chloe Wilson for an educationally-focused podcast, discussing the key messages for clinical practice on heart failure with preserved ejection fraction.

Read the full Seminar:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02756-3/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

Lene Seidler on umbilical cord management at preterm birth

Thu, 21 Dec 2023 23:00:00 +0000

Lene Seidler joins Callam Davidson of The Lancet to discuss umbilical cord clamping strategies at preterm birth following the publication of two systemic review and meta-analyses with individual participant data.

Read the full articles:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02468-6/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)02469-8/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

Emily Chew on the future of treatments for geographic atrophy

Thu, 26 Oct 2023 22:00:00 +0000

Emily Chew joins Chloe Wilson of The Lancet to discuss the future of treatments for geographic atrophy following the publication of two randomised controlled trials of new drug treatments.

Read the full article here:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01583-0/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

Simon Kyle on a new effective treatment for insomnia

Thu, 31 Aug 2023 22:00:00 +0000

Simon Kyle joins Gavin Cleaver of The Lancet to discuss his paper on sleep restriction therapy as a new effective treatment for insomnia.

Read the full article:
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00683-9/fulltext?dgcid=buzzsprout_icw_podcast_generic_lancet

Verna Vanderpuye and Isabelle Soerjomataram on International Women’s Day and cancer

Tue, 08 Mar 2022 00:00:00 +0000

On this International Women's Day, Lancet editors and the co-chairs of the Women and Cancer Commission discuss the burden of women’s cancer on society and reflect on the questions the Commission is trying to answer.

Nick James on the STAMPEDE trial

Thu, 23 Dec 2021 23:00:00 +0000

Nick James discusses the key messages of the recent report from the STAMPEDE trial platform and the success of this platform in advancing the treatment of prostate cancer

Jie Qiao (in Chinese) on reproductive health in China

Wed, 02 Jun 2021 11:00:00 +0000

《柳叶刀》亚洲执行主编王辉对话《柳叶刀中国女性生殖、孕产妇、新生儿、儿童和青少年健康重大报告》共同主席乔杰院士。

Jie Qiao (in English) on reproductive health in China

Wed, 02 Jun 2021 11:00:00 +0000

Helena Wang discusses The Lancet Commission on women's reproductive, maternal, newborn, child and adolescent health (RMNCAH) in China with author Professor Jie Qiao.

Siobhan Quenby & Arri Coomarasamy on miscarriage

Mon, 26 Apr 2021 22:00:00 +0000

Siobhan Quenby & Arri Coomarasamy discuss the key findings from The Lancet's new Series on miscarriage.

Muir Gray

Thu, 25 Feb 2021 23:00:00 +0000

On the 50th anniversary of the Inverse Care Law, Professor Sir Muir Gray joins Gavin Cleaver to discuss the continuing importance of the ICL, and notions of value and quality in health care.

Mary Bassett

Thu, 11 Feb 2021 04:00:00 +0000

The Lancet's new Commission, Public Policy and Health in the Trump Era, looks back at the effects of the last four years on the health of the USA. One of the authors of the Commission, Mary Bassett (Harvard University) joins us to talk about the Commission findings and wider issues facing the USA.

Richard Horton on the Oxford vaccine phase 3 trial

Tue, 08 Dec 2020 15:00:00 +0000

Editor-in-chief of The Lancet, Richard Horton, discusses the results of the Oxford vaccine's phase 3 trial.

Renee Salas

Wed, 02 Dec 2020 23:00:00 +0000

Renee Salas, leader of the Lancet Countdown policy brief in the US, discusses the climate problems facing the US, the issues of the last four years, and the reasons to be optimistic about the future.

Rafael Lozano and Margaret Kruk

Wed, 02 Sep 2020 13:00:00 +0000

Universal health coverage (UHC) is a vital facet of healthcare across the world, and a new Global Burden of Disease paper seeks to measure its spread. The Lancet spoke with author Rafael Lozano and linked Comment author Margaret Kruk about efforts to analyse and measure UHC.

Richard Horton

Mon, 20 Jul 2020 15:00:00 +0000

The Lancet Editor-in-Chief Richard Horton explains the current status of the Oxford and China COVID-19 vaccines, including an overview of current progress and the next steps for both.

Kathleen O’Reilly and Stein Emil Vollset

Tue, 14 Jul 2020 22:00:00 +0000

The new Global Burden of Disease paper forecasts major alterations in worldwide population over the next few decades. We ask Kathleen O’Reilly, of LSHTM, how models are made and how you account for a changing world, and we speak with paper author Stein Emil Vollset of IHME about the implications of his predictions.

Rosanna Peeling

Tue, 07 Jul 2020 11:00:00 +0000

Professor Rosanna Peeling discusses the implications of seroprevalence results from recent COVID-19 antibody studies.

Bin Cao (in Chinese)

Mon, 09 Mar 2020 12:00:00 +0000

柳叶刀亚洲执行主编王辉跟曹彬教授关于2019冠状病毒感染住院患者临床发病过程和死亡危险因素的讨论

Bin Cao

Mon, 09 Mar 2020 12:00:00 +0000

The Asia Executive Editor of The Lancet, Helena Hui Wang, chats with Bin Cao about clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China.

Richard Horton, Sarah Dalglish, and Grace Gatera

Wed, 19 Feb 2020 12:00:00 +0000

Richard Horton, Sarah Dalglish, and Grace Gatera talk about the future for children alive today, alongside findings from the new Commission.