-The truth about GLP-1 receptor agonist weight loss drugs: benefits vs side effects   
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide 
The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ 
Theresa's Instagram: https://www.instagram.com/livingrootswellness/   
Timestamps:

0:00 – intro 

0:39 – unpacking Super Bowl ads for GLP-1 weight loss drugs 

5:15 – why GLP-1 marketing is falling flat: are people waking up? 

10:26 – are pharmaceuticals the solution for the modern food system? 

14:40 – GLP-1 commercial downplays potential serious side effects 

18:22 – the benefits of GLP-1 agonists for glucose metabolism 

19:45 – the major difference between GLP-1 drugs and our own natural GLP-1 hormone 

21:49 – GLP-1 drugs lead to increased risk of depression, anxiety, and suicidal behavior 

23:37 – gut problems, muscle loss, and 4x faster weight regain (additional side effects from GLP-1 drugs) 

25:26 – risk vs. reward for GLP-1 drugs 

29:53 –are GLP-1 drugs safe and effective long-term? 

33:37 – GLP-1 drugs vs. diet and exercise 

38:40 – using GLP-1 drugs for losing the stubborn weight and taking willpower out of the equation 

43:13 – the “metabolic benefits” of GLP-1 medications 

45:21 – whether it ever makes sense to take GLP-1 drugs for weight loss or improved health 

48:31 – weight regain on GLP-1 drugs: are they a sustainable solution? 

50:58 – severe undereating leads to faster weight regain, especially body fat 

56:14 – weighing the convenience of taking weight loss drugs vs the side effects and long-term costs 

58:23 – “food noise” vs. hunger and cravings 

1:02:03 – how to get rid of “food noise” and chronic hunger and cravings 

1:05:08 – sharing a listener success story: from carnivore and sad to crushing life with a bioenergetic approach

Sign up for a free call for help with weight loss and other health issues: https://www.jayfeldmanwellness.com/call/ 

Timestamps:

0:00 – intro 2:16 – Frost (FaceIQ) on why he transitioned away from carnivore to Ray Peat 4:27 – suboptimal blood test markers (low T3, low testosterone, high ferritin, etc) as a result of low-carb diets 6:20 – whether low T3 and elevated stress hormones are a problem on low-carb diets 11:46 – most people on carnivore experience deteriorating health over time 15:18 – debunking carnivore myths: modern fruit is sweeter, humans should be eating seasonally, and humans are not adapted to high sugar levels in fruits 20:57 – whether an increase in dopamine after eating fruit makes it an addictive drug 22:28 – carnivores don’t understand the Randle Cycle 26:19 – “carbohydrates are addictive” 27:24 – digestive symptoms when reintroducing carbohydrates 31:28 – ”once you start eating carbs you have to keep eating them” 33:05 – ”carbohydrates are not essential” 35:40 – the truth about sugar and glycation 39:07 – why the claim that fructose is toxic is false and the benefits of fructose 40:16 – “high-carb = high blood sugar = high glycation” 41:54 – carnivore excuses for high A1c on low-carb 44:01 – proof that low-carb dieting leads to high stress hormones


-Shawn Baker claims gluconeogenesis is fine – is he right? -Dr Rob Cywes on carb addiction, insulin resistance, and bariatric surger   
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide 
The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ 
Theresa's Instagram: https://www.instagram.com/livingrootswellness/   
Timestamps:

0:00 – intro 

0:47 – Shawn Baker compares gluconeogenesis to cholesterol synthesis – is the comparison valid? 

2:47 – is increasing gluconeogenesis through low-carb diets optimal? 

6:54 – problems with upregulating gluconeogenesis: stress hormones, ammonia, muscle breakdown, and insulin resistance 

10:15 – Shawn Baker’s claim that breathing too much isn’t stressful – is that true? 

12:28 – gluconeogenesis as the result of elevated stress hormones – is there a long-term cost? 

14:24 – Shawn Baker’s social media post reveals flawed reasoning and a lack of critical thinking  

17:47 – what “stress” really means and whether cortisol is always harmful 

23:45 – the cost of upregulated gluconeogenesis, elevated glucagon, and low t3 on low-carb diets 

25:15 – Dr Rob Cywes’ claim that carbs do no harm, it’s our relationship with them that’s the problem 

29:09 – Dr Cywes’ claim that glucagon is more important than insulin 

33:33 – you're not addicted to carbohydrates, your body just needs fuel 

38:13 – Dr Cywes contradicts himself on carbs and obesity 

40:37 – native cultures on high-carb diets don’t have obesity or insulin resistance 

43:05 – whether high insulin levels drive fat gain and why low-carb diets don’t prevent insulin excursions 

44:51 – is diet properly considered before bariatric surgery? 

48:08 – many “high-carb foods” are actually high-fat foods 

49:01 – bariatric surgeries ignore other possible root causes of metabolic dysfunction 

49:53 – Dr Cywes misunderstands glucagon, insulin, and cellular energy production 

56:48 – what Dr Cywes gets right: stress hormones increase in reaction to a cellular energy deficiency 

58:57 – elevated glucagon drives insulin resistance and whether glucagon resistance exists 

1:03:41 – reversing keto damage: weight loss, gut, and brain health on a bioenergetic approach


-The calories in calories out model of obesity  -Dr Boz’s take on fruit and blood glucose spikes -Richard Smith on aging and the NAD+ to NADH ratio   
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide 
The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ 
Theresa's Instagram: https://www.instagram.com/livingrootswellness/   
Timestamps: 0:00 – intro 

1:17 – Is fruit evil or is Dr Boz insulin resistant? 

5:00 – whether high blood glucose levels drive Alzheimer’s and dementia 

7:39 – does glucose automatically get converted to fructose and fat? 

10:58 – Dr Boz & Glucose Goddess’s fearmongering about fruit and glucose spikes  

14:12 – Dr Boz parrots Robert Lustig: they’re both wrong about fructose 

15:43 – concerns with blood sugar spikes when reintroducing carbs and whether using a CGM is worth it 

17:32 – less, not more, glucose uptake in the brain creates the conditions for Alzheimer’s disease 

20:15 – poor glucose utilization as a driver of Alzheimer’s and dementia 

22:48 – reducing carbohydrate intake causes insulin resistance and less metabolic flexibility 

26:27 – possible reasons for Dr Boz’s high blood sugar and our advice for Dr Boz 

30:31 – our experiences with “keto snacks” and how keto caused intense cravings and binging 

33:53 – Richard Smith on keto, NAD+ and aging 

35:23 – what Richard Smith misses about glucose and the NAD+ to NADH ratio 

41:00 – glucose metabolism leads to a higher NAD+ to NADH ratio than ketone metabolism 

44:15 – how low-carb diets can restore the NAD+ to NADH ratio through stress pathways 

47:02 – whether ketones are beneficial 

49:57 – fats vs carbs: which is the better fuel for the NAD+ to NADH ratio? 

55:17 – how to support healthy aging and NAD+ levels (hint: not low-carb) 

1:00:31 – what the NAD+/NADH ratio actually indicates 

1:05:02 – lower blood sugar with a bioenergetic approach

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution here:

https://www.jayfeldmanwellness.com/energy-balance-solution/

  Timestamps:

0:00 – intro 

0:47 – Sean’s professional bodybuilding career and how excessive exercise harmed his health 

5:50 – Sean’s experience with various diets (keto, carnivore, fasting, low-carb, carb-cycling, low-fat, etc.) 

12:37 – issues with the low-fat craze of the 1980s and the cost of constant diet cycling 

18:09 – excess protein slowed Sean’s metabolism and caused major gut issues 

24:35 – how the sugar diet helped Sean recover from excess protein intake and low-carb diet stress

29:15 – using colon massage and myofascial release to support digestive health 

31:23 – sugar diet results and how it impacted Sean’s bodybuilding competition and sleep

34:36 – muscle loss, lower energy, and cravings on the sugar diet

36:33 – how Sean transitioned to a more balanced approach while listening to his cravings and hunger signals 

40:23 – when it comes to exercise, more is NOT always better 

42:26 – improved health and freedom from listening to your body with the bioenergetic approach 

46:27 – how to reverse autoimmune conditions like ankylosing spondylitis (AS) using a bioenergetic approach 

49:04 – Sean’s advice to young athletes on how to support long-term health 

50:43 – how Sean overcame health dogmatism


-The calories in calories out model of obesity  -What really causes fat storage  -Whether there are any concerns with consuming organ meats    
Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide 
The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/ 
Theresa's Instagram: https://www.instagram.com/livingrootswellness/   
Timestamps: 0:00 – intro  0:56 – Nick Norwitz’s claim that calories don’t cause obesity and whether we agree  6:25 – the value and limitations of calories   14:27 – the true cause of obesity  19:40 – “excess calorie intake causes weight gain” is unhelpful and irresponsible  23:28 – how and when measuring calorie intake can be valuable  27:24 – do calories matter?  32:28 – how “it’s just calories” often places blame on the individual  34:26 – Nick Norwitz on when the calories-in-calories-out model “breaks”  37:28 – hypothyroidism and weight gain resolved using a bioenergetic approach  38:26 – thoughts on organ meats like liver, heart, kidney, stomach, and intestine  42:41 – freeze-dried or desiccated vs fresh organ meat  45:12 – Nutrition with Judy’s claim that “liver is not a superfood”  47:11 – can you overdose micronutrients like vitamin A and copper from organ meats?  49:43 – strategies for including more organ meats in your diet

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution here:

https://www.jayfeldmanwellness.com/energy-balance-solution/

Timestamps:

0:00 – intro

0:25 – why your vitamin D levels are still low despite supplementing

3:17 – the dangers of low vitamin D for bone health & immune function

7:16 – essential nutrients and food sources to resolve low vitamin D

17:25 – top supplement recommendations for optimal vitamin D

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

1:03 – Ray Peat’s view on fasting for 12–15 hours without triggering stress 

4:22 – the true definition of stress and how much stress is optimal 

9:18 – how the efficiency of glucose metabolism and glycogen storage impacts stress 

12:23 – whether we agree that fasting for 12–15 hours doesn’t cause stress in healthy people 

17:05 – do hunger signals mean the stress response has already started? 

21:08 – the short- and long-term costs of low carb diets 

22:22 – finding balance between eating frequently to reduce stress and spacing meals out strategically 

24:47 – why meditation, magnesium, and other tools don’t stop physiological stress 

27:04 – Ray Peat on what happens when stored glucose (glycogen) runs out 

28:53 – hypothyroidism as a driver of poor glucose utilization and liver glycogen storage 

31:50 – stress hormones and elevated fatty acid metabolism characterize the stress response 

34:50 – ketosis mimics starvation and lowers the metabolic rate 

36:50 – sugar is anti-stress and whether sugar is addictive 

41:46 – once you add in carbs you won’t go back 

44:12 – how your body adapts when you add in carbs following low-carb diets 

48:30 – Ray Peat on the harmful effects of fasting 

50:14 – the cost of stress and increased fat metabolism 

52:06 – the dangers of releasing PUFA from storage and how long it takes to deplete PUFA 

55:11 – strategies for protecting against PUFA 

1:01:50 – how long it takes to see benefits from lowering PUFA and setting expectations for progress 

1:06:00 – binge-eating and food addiction resolved with a bioenergetic approach 

1:10:48 – how low-carb and keto diets cause intense cravings and food obsession while a bioenergetic approach resolves them

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:32 – recap of Justine Stenger’s claim covered in episode 19 

2:26 – Justine’s response to our critique of her post 

5:45 – why it’s crucial to separate personal feelings from intellectual discussions, especially when sharing information publicly 

10:48 – our goal as health educators is not to shame or discredit individuals 

13:33 – how today’s social media environment incentivizes low quality, thoughtless posts 

18:30 – why attention and clicks take priority over quality on social media 

21:34 – how to discern reliable information and whether we should outsource understanding to specialists 

26:49 – how to develop true discernment in a world full of self-proclaimed experts 

30:19 – Justine Stenger doubles down on her claim that fats are superior to carbohydrates32:47 –do carbs or fat better supports a compromised metabolic state? 

39:45 – Justine contradicts her earlier claim that fat is a cleaner-burning fuel than carbohydrates 

43:10 – Justine Stenger’s claim that glucose oxidation is only beneficial during hypoxia or the cell danger response 

49:55 – why carbohydrates are the superior fuel source 

55:17 – the difference between glucose oxidation and anaerobic glycolysis, and whether Justine is conflating the two 

57:28 – how Ray Peat’s metabolic framework drives growth and expansion in society as a whole 

1:01:53 – why having metabolic flexibility in a healthy state doesn’t refute our argument that carbohydrates are the superior fuel 

1:08:23 – the inherent cost of favoring fat metabolism over carb metabolism, and why restoring carbohydrate utilization is essential for restoring a healthy metabolism 

1:13:30 – Justine admits she hasn’t studied Ray Peat’s work 

1:19:17 – Justine’s claim that it’s optimal to switch between fuel sources 

1:20:55 – Justine’s claim that redox matter more than carbs vs fats 

1:25:11 – did we publicly dismantle Justine’s work, and is it okay to critique others? 

1:31:26 – Justine’s hypocritical shaming of us for addressing her incorrect claims about Ray Peat’s work and glucose vs. fat metabolism1:39:48 –there is no “Ray Peat Diet” 

1:40:20 – how to embrace criticism and whether debates are typically helpful 

1:45:04 – the responsibility that comes with being health educators 

1:48:33 – common problems with debates and why we aren’t interested in debating Bart Kay 

1:52:09 – how the nervous system impacts our ability to think critically 

1:52:56 – problems with debates cont’d – are debates truly valuable? 

1:57:24 – blood sugar improvements on a bioenergetic approach

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution here:

https://www.jayfeldmanwellness.com/energy-balance-solution/

  Timestamps:

0:00 – intro 

0:57 – how Andrew was introduced to Ray Peat, the bioenergetic view of health, and Jay’s energy balance approach 

5:48 – why we structure our programs with teaching the “why” alongside clear action steps and strategies 

8:41 – increased energy and lower blood sugar levels while increasing carbohydrates 

15:09 – how the Energy Balance approach resolved nighttime binging, high blood pressure, gut issues, and improved sleep quality 

19:02 – how restricting carbohydrates leads to binging and “carbohydrate addiction” 

21:33 – setting health and weight expectations: how long does it really take to heal your metabolism? 

27:07 – refeeding, weight regain, and paying back metabolic debt: the process of losing weight without compromising your health 

31:20 – the importance of keeping a health journal and documenting symptoms and wins 

33:46 – weight loss as a result of improved health 

41:29 – the cost of losing body fat by cutting calories 

47:08 – how we work with clients using the Energy Balance approach 

49:57 – how extreme diets isolate, while Energy Balance reconnects us by removing food dogma and providing the energy for healthy connection 

55:31 – Andrew’s experience learning and applying the Energy Balance system 

59:23 – how we structure the Energy Balance programs to foster learning and create lasting health improvements 

1:07:02 – how the Energy Balance approach reshaped Andrew’s coaching style 

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution here:

https://www.jayfeldmanwellness.com/energy-balance-solution/

  Timestamps:

0:00 – intro  1:03 – introducing Andrew Wallen 


1:50 – Andrew’s background in sports, powerlifting, bodybuilding, and Brazilian Jiu-Jitsu 


6:20 – Andrew’s experience cycling through various dietary camps (CICO, paleo, ancestral, carnivore, fasting, low-carb, etc.) 


12:04 – whether we should shape our diets around what our ancestors did 
15:15 – how low-carb, keto, and fasting diets elevated stress and caused blood sugar issues for Andrew 


20:45 – “optimal” blood glucose, HRV, and resting heart rate despite crashing health 


23:50 – how stress-inducing (hormetic) health practices led to binging, self-blame, low brain energy, high blood pressure, and weakened immune function 


27:36 – low-carb, keto, carnivore, fasting, and fear about reintroducing carbs 


33:13 – Andrew’s breaking point with health and what led him to start questioning what being “healthy” really meant 


36:27 –exercise intolerance, fatigue, pre-diabetes, high blood pressure, brain fog, gut issues, slow motility, and poor sleep: the product of years of low-carb and fasting 

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution here:

https://www.jayfeldmanwellness.com/energy-balance-solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/non-toxic-product-recommendations-for-your-home-body-cookware-skincare-clothing-emfs-more/

Timestamps:

0:00 – intro

2:29 – the hidden costs behind cheap products 


5:42 – health concerns with common cookware: Teflon, non-stick coatings, PFAS, and leaching 


9:34 – concerns with cast iron and carbon steel cookware 


12:14 – how stainless steel compares to cast iron and carbon steel and concerns with nickel 


15:20 – glass cookware and ceramic cookware 


16:56 – the best cookware options 


19:54 – recommendations for low-PUFA skincare 


21:58 – recommendations for vitamin D and UV light


24:54 – the negative effects of synthetic clothing materials 


27:46 – recommended brands for clothing, bedding, towels, and other fabrics 


29:08 – coffee brands I trust and what to look for when buying coffee beans 
30:30 – EMF protection and air tube headphones 


33:09 – recommendations for high-quality meat 

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution here:

https://www.jayfeldmanwellness.com/energy-balance-solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-139-the-truth-about-the-randle-cycle-why-you-can-eat-carbs-and-fats-together/

Timestamps:

0:00 – intro 

0:53 – misconceptions regarding the Randle cycle in the alternative health world 

4:57 – what is the Randle cycle? 

7:06 – what most people get wrong about the Randle cycle 

10:44 – fat oxidation leads to increased ROS production and a decreased NAD+/NADH ratio 

16:29 – how fat oxidation inhibits the utilization of carbohydrates 

21:03 – the Randle cycle shows the benefits of burning carbs for energy 

25:56 – how fat oxidation inhibits the utilization of carbohydrates cont’d 

26:57 – metabolic dysfunction, not glucose, drives insulin resistance and aging 

32:07 – fat metabolism causes a buildup of citrate which reduces glucose uptake and utilization 

38:39 – how glucose oxidation inhibits the uptake and utilization of fats 

45:32 – whether you can “activate” or “deactivate” the Randle cycle 

47:22 – glucose oxidation leads to an optimal NAD+/NADH ratio and decreased ROS production 

52:08 – the protective effects of CO2 and why the brain can’t use fats as a fuel 

53:17 – whether we should strive for metabolic flexibility 

55:55 – fat metabolism and ketone production as a mechanism for energy conservation and glucose sparing 

1:00:02 – insulin resistance as a state of excess fat metabolism and decreasing fat metabolism or stress hormones improves this state 

1:05:28 – should we avoid eating carbs and fats together due to the Randle cycle? 

1:08:08 – different cells, tissues, and organs can use different fuels at the same time 

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution here:

https://www.jayfeldmanwellness.com/energy-balance-solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-138-low-carb-diets-increase-glycation-and-what-to-do-instead/

Timestamps:

0:00 – intro 

0:57 – how glycation products are detoxified and cleared from the body 

4:03 – glycation detoxification is impaired by oxidative stress and inflammation, as seen in type 2 diabetes 

7:56 – the benefits of carbohydrates for the detoxification of glycation products 

10:42 – the benefits of insulin for the detoxification of glycation products 

12:45 – how AGEs are cleared 

14:36 – increasing autophagy via hormesis is not the answer for clearing AGEs 

19:09 – autophagy can drive disease 

20:50 – ATP protects against oxidative stress and allows for proper autophagy when needed 

24:37 – impaired mitochondrial along with fatty acid oxidation impairs autophagy and increases oxidative stress 

26:54 – carbohydrates do NOT inhibit autophagy 

29:18 – adequate thyroid hormone supports proper autophagy 

30:15 – adequate ATP and mitochondrial function is needed for the UPS (ubiquitin proteasome system) 

32:56 – do high-carb diets actually impair metabolism and insulin sensitivity 

35:26 – is fructose really worse for blood sugar regulation and glycation? 

37:16 – are low-carb or ketogenic diets the solution to reduce glycation? 

40:32 – increased glycation and oxidative stress on ketogenic diets 

44:09 –low-carb diets don’t prevent glucose exposure 

47:56 – there are still considerable insulin and glucose excursions on low-carb diets 

50:06 – gluconeogenesis leads to same glycolytic intermediates as glucose metabolism 

51:52 –the main driver of AGE formation and impaired AGE clearance 

53:40 – the role of vitamin B1 (thiamine) and mitochondrial energy production in decreasing AGEs 

56:27 –endotoxin as a driver of glycation and increased AGE production 

58:12 – hypothyroidism as a driver of glycation and AGE accumulation 

59:37 – dietary solutions for reducing glycation and AGEs 

1:03:33 – how to support the glyoxalase pathway to support the detoxification of glycation products 

1:05:56 – avoid calorie restriction, low-carb diets, fasting, resveratrol, cold exposure, excess exercise, and iron overload to decrease glycation and AGEs 

1:07:33 – iron as a double-edged sword for oxidative stress 

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution Program here:

https://www.jayfeldmanwellness.com/energy-balance-solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-137-what-really-causes-glycation-is-sugar-really-the-problem/

Timestamps:

0:00 – intro 

0:46 – common beliefs about carbohydrates and glycation 

2:35 – what are glycation and advanced glycation end products? 

6:57 – the process of glycation from glucose 

9:30 – is sugar the only source of AGEs? 

15:00 – primary drivers of glycation: dicarbonyls 

19:30 – how fatty acids, amino acids, and ketones cause AGE formation 

21:23 – how increased gluconeogenesis on low-carb diets increases AGE formation 

22:53 – glucose metabolism produces very few glycation products in the context of a healthy metabolism 

25:33 – omega-6s form AGEs more than 10x faster than glucose 

28:24 – the role of ALEs (advanced lipoxidation end products) in glycation and chronic disease 

30:36 – whether blood sugar spikes cause glycation 

38:52 – whether fructose causes more glycation (or fructation) than glucose 

47:05 – can glycation from fructose (fructation) be measured, and does this matter? 

52:06 – problems with research looking at fructose’s AGE formation in animal models 

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

2:10 – David Stephens’ claim that glucose can't harm you in any way, no matter the amount 

7:46 – the difference between glucose and fructose and whether fructose just gets converted to fat 

11:13 – whether extreme acidity, alkalinity, and corrosivity are what make substances harmful to humans 

15:14 – David Stephens’ claim that sucrose can't cross the blood-brain barrier  

18:59 – how authoritarianism shapes the health industry and the difficulties of verifying information with AI 

23:14 – whether the “chemical heaviness” of sucrose means that it can’t be helpful in the body 

25:51 – whether we agree with David Stephens on the benefits of glucose 

29:14 – whether anxiety, irritability, depression, autoimmune disorders, and diabetes are caused by a lack of glucose for your brain 

34:37 – what David Stephens misses about the large amounts of glucose he recommends – poor glucose utilization, gut issues, and blood sugar instability 

38:06 – whether glucose deficiency is possible and whether most people are eating enough carbs to thrive vs survive 

39:04 – David Stephens’ claim that it’s impossible for glucose to be harmful to the body in any way 

45:25 – why someone might feel better using large amounts of dextrose as their main carbohydrate source 

48:00 – how large quantities of glucose can lead to weight gain, blood sugar spikes, and cardiovascular problems 

52:27 – how to avoid dietary extremes and what balance really means 

58:41 – weight loss and recovery from mental health issues using a bioenergetic approach 

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:21 – what Huberman misses when it comes to nighttime wakeups 

4:50 – the most common causes of nighttime wakeups and how to resolve them 

9:44 –Huberman’s advice to go to sleep earlier is impractical for most people 

11:42 – what a healthy sleep schedule looks like and whether running out of melatonin is a concern 

13:38 – the relationship between blood sugar and sleep, and whether to have a bedtime snack 

16:21 – common drivers of sleep disturbances: gut irritation and elevated stress hormones 

19:25 – hidden stressors that could be impacting your sleep: SSRIs, EMFs, devices, and more 

22:13 – how to handle unavoidable stressors that interfere with sleep 

24:05 – strategies for improving sleep quality and circadian rhythm 

26:32 – whether to avoid drinking too many fluids before bed 

27:52 – the metabolism-suppressing effects of melatonin and whether supplementing with melatonin is a good idea 

29:48 – supplements that may interfere with sleep, and paradoxical reactions that occur while using medications such as SSRIs 

33:09 – sleep strategies for shift-workers and recovering from working night shifts 

36:33 – the effects of Wi-Fi, EMFs, and dirty electricity on sleep 

39:21 – how hormones impact sleep for post-menopausal women 

40:54 – evaluating whether supplements are affecting your sleep 

44:34 – how low-carb diets impair sleep and increase stress 

47:01 – improved thyroid function and weight loss on a bioenergetic approach 

48:14 – meeting daily micronutrient needs with food and supplementation 

52:57 – how to identify nutrient gaps and excesses 

55:37 – which labs to get to gauge micronutrient status and how thiamine (vitamin B1) impacts nutrient absorption 

1:00:00 – how concerned should we be with nutrient absorption? 

1:03:00 – how anti-nutrients like phytates and oxalates impact nutrient absorption 

1:04:37 – navigating different forms of nutrients (non-heme iron vs heme iron, retinol vs beta-carotene, and vitamin K2 vs vitamin K1), and how to know if gut issues are interfering with nutrient absorption 

1:07:42 – problems with dietary camps that demonize single nutrients (low vitamin A, low vitamin D, and iron overload) 

1:11:24 – how fear and stress deplete critical nutrients

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:32 – Justine Stenger’s claim that Dr Ray Peat had it all wrong 

6:15 – did Ray Peat ignore physics, structured water, and light? 

11:41 – carbs vs fat: which fuel produces more ROS? 

16:50 – Justine Stenger’s claim that carbs act as a crutch for a damaged metabolism, and restoring redox is the solution 

21:58 – carbs vs fat: which fuel produces more ATP? 

25:27 – conflicting health information on social media and why the “Ray Peat diet” doesn’t work 

31:55 – common challenges with implementing Ray Peat’s work 

34:09 – Justine Stenger’s mischaracterization of Ray Peat’s work as a “dietary roadmap for people with a broken metabolism” 

41:20 – why you shouldn’t outsource critical thinking to social media influencers or AI 

45:17 – Ray Peat’s generosity with freely sharing advice and information 

46:21 – improvements on a bioenergetic approach without extreme restriction 

47:31 – why you may experience bloating from carbs and what to do about it 

54:52 – what to do about gut dysbiosis and biofilms 

56:56 – how to restore gut health and digestion when transitioning away from keto

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-136-eric-westman-debate-follow-up-part-2-high-carb-diets-cause-insulin-resistance-overeating-and-glycation/

Timestamps:

0:00 – intro 

1:02 – Isabella Cooper paper: does shifting from a low-carb diet to a high-carb diet increase inflammation? 

9:12 – whether you should be concerned about low T3, low testosterone, or high glucagon on a low-carb diet 

16:53 – how we know that the brain does not use fat as a fuel source 

20:59 – whether a low metabolic rate on a low-carb diet allows you to live longer 

25:13 –increased fatty acid oxidation drives insulin resistance 

31:12 – increased fat metabolism in the heart occurs in type 2 diabetes, heart disease, and heart failure, and decreasing this fat metabolism improves cardiovascular health and insulin sensitivity 

36:37 – whether babies being born in ketosis means that being in ketosis is beneficial for adult humans 

40:29 – do high-carb diets cause glycation? 

41:56 – low-carb diets don’t eliminate blood sugar and insulin spikes 

46:10 – evidence that high-carb diets don’t cause chronically high blood sugar and insulin levels 

49:56 – the benefits of high-carb diets on insulin resistance 

55:33 – are carbs inherently addictive? do they cause overeating? 

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/eric-westman-debate-follow-up-the-research-on-low-carb-vs-high-carb-diets/

Timestamps:

0:00 – intro 

1:05 – why I’m recording this debate follow-up 

3:38 – how the body responds to carbohydrate restriction and the broader biological context 

9:47 – the mitochondrial effects of low-carb diets: glycolysis vs beta-oxidation, NADH/FADH2 ratios, NAD+/NADH ratios, and effects at the electron transport chain 

15:16 – fat oxidation leads to slower rates of ATP production and higher rates of ROS production 

18:14 – how fat oxidation blocks glucose utilization, slows mitochondrial respiration, and reduces carbon dioxide production 

20:58 – ketone vs. glucose metabolism  

21:52 – glucose metabolism confusion, glycolysis, and whether ketones are beneficial  

24:25 – the hormonal effects of low-carb diets 

28:13 – how do we know that fat metabolism is less efficient than glucose metabolism? 

34:09 – whether research on fat metabolism in rodents applies to humans and other animals 

37:02 – the research showing that fat oxidation increases ROS production and reduces mitochondrial efficiency in various animals (including humans) 

40:31 – the research showing the mechanisms of increased ROS production and reduced efficiency of ATP production with fatty acid metabolism 

47:41 – mitochondrial uncoupling increases during fat metabolism due to increases in oxidative stress 

49:19 – are there adaptations on a keto diet that would prevent the harmful effects of fat metabolism? 

52:48 – are there biopsies done on long-term ketogenic diets showing that fat oxidation doesn’t lead to a decreased NAD+/NADH ratio and more ROS production? 

59:17 – whether increased fatty acid oxidation enzymes would reduce ROS production in the mitochondria as Dr. Westman suggested 

1:02:58 – low-carb and ketogenic diets in rodents cause increased oxidative stress and less efficient ATP production  

1:11:41 – do ketones protect against ROS? 

1:16:18 – do the potential positive effects of ketones outweigh the negative effects of ketogenic diets? 

1:27:47 –low-carb and ketogenic diets cause oxidative stress and insulin resistance in humans1:36:30 – the evidence that glucagon is a stress hormone 

1:39:45 – low-carb and ketogenic diets cause physiological stress in humans 

1:43:46 – the effects of low-carb and ketogenic diets on cortisol 

1:48:29 – low-carb and ketogenic diets decrease thyroid activity 

1:53:54 – effects of low-carb and ketogenic diets on reproductive hormones

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:18 – why Ryan Fischer’s claim that the body only changes weekly is false 

6:38 – major problems with the “calories in, calories out” model of weight loss  

11:27 – Ryan Fischer’s claim that it takes 3,500 calories to gain one pound 

15:07 – whether it’s possible to have more “freedom” on the weekends without wrecking your health 

18:11 – Jesse James West & Jeff Nippard on apples vs Sour Patch Kids: are calories all that matter? 

24:29 – what calories actually represent and their true role in health 

29:03 – is sugar always bad for you? 

32:25 – whether tracking calories has any real value 

34:21 – problems with equating weight loss with health 

38:15 – how to know if excess calories are actually an issue for you 

45:33 – why high FODMAP fruits like apples may cause bloating and which fruits would be a better option 

49:40 – strategies for reversing lactose intolerance 

56:35 – what really drives lactose intolerance and how to tell if it’s affecting you 

58:34 – factors that affect lactose intolerance and additional strategies to reverse lactose intolerance 

1:04:18 – do leafy greens, digestive enzymes, or slippery elm help with lactose intolerance?

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:24 – the costs of metformin: mitochondrial toxicity, increased lactate, inefficient ATP production, and slowed metabolism 

5:22 – is using Metformin a good idea on the sugar diet? 

10:30 – the dangers of increasing FGF21 while on Metformin 

13:53 – increasing FGF21 activity is counter to the bioenergetic view of health 

20:23 – Hunter Williams’ supplement stack for insulin sensitivity: metformin, Jardiance, retatrutide, and dihydroberberine 

21:42 – the negative effects of Jardiance 

24:59 – whether retatrutide and other GLP-1 agonists are healthy from a bioenergetic perspective 

27:30 – whether there are any benefits to using medications like metformin, Jardiance, retatrutide, and dihydroberberine 

31:54 – how increasing FGF21 with the sugar diet could lead to heart problems such as arrhythmias and atrial fibrillation (AFIB) 

38:58 – does the sugar diet boost metabolic rate the same way the bioenergetic approach does? 

46:27 – examples of how the sugar diet downregulates metabolism through stress 

50:51 – the cumulative effects of stress: how much stress can we handle? 

55:15 – how to recover from the negative effects of the sugar diet 

58:24 – is stress beneficial? is it possible to avoid stress altogether? 

59:51 – problems with dropping fat too low, especially in lean individuals 

1:03:50 – the risks of rapid weight loss and the importance of keeping long-term goals in mind 

1:08:02 – why cutting out entire macronutrient groups can backfire and what to do instead 

1:11:20 – how extreme diets prime our bodies for weight regain 

1:14:54 – real-life examples of weight regain after the sugar diet and why it happens 

1:20:18 – is there a smarter way to do the sugar diet? 

1:24:01 – are there legitimate benefits to the sugar diet? 

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:37 – Cole Robinson flip-flops his recommendations on the sugar diet 

7:43 – problems with using weight loss as the primary determinant of health 

12:43 – Cole Robinson’s early recommendations on sugar fasting 

14:16 – the impact of the sugar diet on gut and dental health 

16:40 – the importance of understanding how a diet works rather than focusing solely on the short-term results 

20:26 – the benefits of eating fruit rather than white sugar sources like candy 

21:58 – concerns with blood sugar stability on low-fat diets 

23:49 – problems with taking a “1990s low-fat approach” as Cole Robinson recommends 

26:18 – Cole Robinson’s flip flop on the sugar diet 

31:48 – concerns with digestion and liver detoxification on a low-fat diet 

34:46 – Cole Robinson’s history of changing dietary recommendations – from the Snake Diet to the Sugar Diet 

36:13 – whether the sugar diet could be used as a short-term tool to lose body fat 

38:30 – the many iterations of advice on the sugar diet from Cole Robinson 

39:53 – the importance of losing body fat in a healthy way 

42:32 – will the 1990s low-fat diet last? 

45:29 – whether having enough carbohydrates protects against muscle loss while on the sugar diet 

46:57 – caution for those trying the sugar diet for weight loss 

51:50 – FGF21 requires a protein deficiency 

53:48 – why Cole Robinson’s new low-fat diet may not lead to rapid weight loss like the sugar diet 

57:54 – the sugar diet shows that sugar isn’t the cause of insulin resistance 

1:03:41 – did Cole Robinson actually lie about what he his original sugar diet recommendations? 

1:13:27 – the toxic nature of social media and its impact on learning 

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution here:

https://www.jayfeldmanwellness.com/energy-balance-solution/

Sign up for a free call for help with weight loss and other health issues: https://www.jayfeldmanwellness.com/call/ 

Timestamps:

0:00 – intro  4:29 – Ben Bikman suggests the sugar diet only works for lean, active, healthy men

9:33 – Ben Bikman’s claim that satiety is lower on high-carb diets

14:37 – Ben Bikman parrots the argument that carbohydrates are not essential

19:40 – Thomas DeLauer on sugar fasting and insulin sensitivity

22:15 – Thomas Delauer says high-sugar diets cause glycation and AGEs 24:44 – Ken Berry and Anthony Chaffee fearmonger about glycation, glucose, and insulin

28:01 – the truth about glycation on high-carb diets

31:48 – how low-carb diets can cause glycation and increase AGEs

35:22 – Nick Norwitz says the sugar diet won't work for obese people due to FGF21 resistance

39:14 – Nick Norwitz claims that fructose harms the liver

44:24 – Nick Norwitz also parrots the argument that carbohydrates are not essential

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Kate's Instagram: https://www.instagram.com/katedeeringfitness/

Timestamps:

0:00 – intro 

0:22 – Kate Deering’s experience in the Bioenergetic space and finding Ray Peat’s work 

3:02 – Dr. Jolene Brighten says that HRT isn’t enough – is she right? 

6:15 – common diet misconceptions for women in perimenopause and menopause 

9:59 – concerns with using estrogen therapy 

14:03 – how estrogen compares to progesterone, DHEA, pregnenolone, and testosterone 

16:37 – harmful medical advice given to Mike’s mom 

18:17 – whether using estrogen therapy is ever warranted 

24:51 – how to tell if estrogen is causing harm in post-menopausal women 

30:58 – strategies for reducing symptoms associated with menopause (hot flashes, weight gain, vaginal dryness, poor sleep) 

37:16 – blood markers that indicate high estrogen levels and common pitfalls to be aware of 

40:13 – the importance of eating enough carbohydrates to prevent cortisol spikes 

47:14 – Primal Bod (Candi Frazier’s) argument that more insulin leads to a greater need for nutrients 

51:47 – whether RDA targets for micronutrients should be ignored 

57:45 – whether high-carb diets cause the wasting of nutrients as Primal Bod suggests 

1:03:59 – nutrient deficiencies on the carnivore diet and the demonization of insulin 

1:09:56 – is adding fiber the key to hormonal balance? 

1:15:46 – the importance of understanding why removing fiber and other plant foods might produce benefits 

1:18:36 – the bioenergetic approach still applies to post-menopausal women 

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:32 – Max Lugavere and Jordan Peterson discuss the idea that carbohydrates are not essential 

7:42 – carbs ARE essential to our physiology 

15:24 – Bill Burr discusses his fasting practices with the goal of fat loss 

23:18 – fasting concerns and the problem with using restriction and willpower for weight loss 

27:10 – Bill Burr is an example of how food restriction and fasting causes food obsession 

32:52 – why sugar cravings do NOT mean that you are a sugar addict 

38:48 – what the Minnesota Starvation Experiment teaches us about restriction 

40:16 – the psychological and emotional harm caused by fasting 

50:31 – Bill Burr’s fear of spiking blood sugar levels 

53:19 – if fasting makes you feel better, it's a sign your diet isn't working

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:38 – Dr. Ken Berry’s claim that humans historically ate fruit and honey to gain weight like bears for the winter 

3:45 – whether fructose and fruit are responsible for weight gain in bears and whether this applies to humans 

8:53 – whether humans evolved eating a high-carb diet 

11:30 – what about carbohydrate consumption in native human cultures and ancestral environments? 

17:27 – Dr. Ken Berry’s claim that fructose is 10x more glycating than glucose 

20:51 – whether sugar and carb consumption cause high blood sugar and AGEs (advanced glycation end products) 

27:05 – how low-carb diets can increase glycation and AGEs 

32:22 – blood glucose and hemoglobin A1C are often higher on low-carb diets than on diets that include healthy carbohydrates 

33:41 – how keto diets cause glycation and increase AGEs 

37:41 – what really influences hemoglobin A1C levels 

44:32 – the importance of finding optimal carb sources – why candy is not the same as fruit 

45:43 – problems with hyper-focusing on one single lab value  

48:18 – Dr. Ken Berry’s claim that there is no way to test whether fructose is causing glycation 

54:05 – regulating blood sugar for type 1 diabetes 

59:01 – is glycation happening in the background on a high-carb diet even if your health is improving? 

1:00:17 – can we trust AI like Grok and ChatGPT to provide accurate health information? 

1:07:42 – debunking Grok’s logic on carb vs. fat efficiency as a fuel source 

1:13:16 – how to properly use AI – DON’T use it to replace your own thinking 

1:18:01 – Grok is wrong about fat being a more efficient fuel source than carbs 

1:22:33 – strategies for understanding complex research papers 

1:24:14 – using personal experience and logic as a guide toward optimizing health 

1:32:35 – the gratification that comes with the process of true learning 

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

1:21 – Gary Brecka’s claim that methylation is responsible for T4 to T3 conversion 

5:43 – how T4 to T3 conversion really happens and factors that inhibit it 

10:17 – whether a lack of T3 is the primary problem in Hashimoto’s thyroiditis 

12:53 – whether taking exogenous thyroid medications harms the thyroid gland 

18:19 – Gary Brecka’s advice on how to fix Hashimoto’s and why we disagree 

24:14 – be careful of quick fixes and magic pills  

26:38 – pros and cons of using thyroid hormone replacement therapy 

30:17 – issues with thyroid supplementation recommendations within the Bioenergetic sphere 

37:38 – whether you can reverse hypothyroidism without using thyroid supplementation 

41:31 – Joe Rogan and Gary Brecka discuss why the processing of seed oils is responsible for their harm  

47:30 – whether processed foods are inherently bad 

49:23 – are there any benefits to eating PUFA and are they “essential”? 

52:28 – the toxic effects of PUFA, including from nuts & seeds 

55:19 – potential benefits from nuts & seeds are not due to PUFA content 

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:45 – Gabrielle Lyon on the amount of carbohydrates we can “dispose of” in a meal 

8:52 – whether Gabrielle Lyon’s claim that excess carbohydrates turn into fat is valid 

12:39 – do we need to “earn our carbs” with exercise? 

18:32 – how upregulating gluconeogenesis by not consuming carbohydrates drives insulin resistance 

21:27 – do low-carb high-protein diets support skeletal muscle health? 

22:56 – strategies for adjusting macronutrients to fit your individual needs 

29:24 – how to shift away from low-carb diets, focusing on what’s optimal rather than minimum requirements 

31:44 – optimal carb intake for muscles and general health  

34:57 – applying Ray Peat’s “perceive, think, act” process to optimize our diets 

39:29 – the difference between parroting information and thinking critically 

43:20 – cold plunging calms the nervous system by first driving excessive stress 

48:36 – the cumulative effects of stressors like cold plunging and the risks associated with them 

53:41 – whether the benefits of cold exposure outweigh the costs and how much stress is too much 

56:28 – how hormesis works and whether the dose makes the poison  

1:01:34 – what is stress and how do we prevent it? 

1:05:09 – how to get the same benefits without using hormetics like fasting, Wim Hof breathing, and cold exposure 

1:10:35 – does reaching a goal have to be difficult or stressful? 

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-134-the-sugar-diet-lose-fat-and-increase-your-metabolism-without-losing-muscle-mass

Timestamps:

0:00 – intro 

1:08 – FGF21 summary: increasing metabolism at a cost 

4:06 – how the sugar diet, honey diet, and other similar diets actually work 

10:03 – low-fat diets improve insulin sensitivity, even without protein restriction or FGF21 upregulation 

17:50 – whether very low protein diets are ever beneficial and whether they always lead to muscle loss 

25:54 – protein recommendations for insulin sensitivity, weight loss, and kidney function 

29:07 – using the sugar diet for rapid weight loss or “getting shredded” 

32:13 – sugar diet concerns: bone loss, infertility, stunted growth, muscle loss, metabolic suppression, weight regain, and nutrient deficiencies 

35:53 – will eating protein with dinner prevent the negative effects? 

36:28 – blood sugar instability, sleep issues, and excess glucagon on the honey diet and sugar diet 

40:17 – Randle Cycle misconceptions: do you need to separate carbs and fats 

44:50 – how low-fat diets work to improve glucose metabolism and misapplications of the Randle cycle 

48:17 – low-fat diets and hormones: low testosterone and DHT levels in men 

49:22 – the sugar diet and digestion: SIBO, impaired liver detoxification, low bile flow, and endotoxin 

53:52 – is the sugar diet too restrictive? Is it sustainable? 

59:57 – how to modify the sugar diet to reduce the negative effects 

1:02:23 – how to achieve lasting weight loss while improving long-term health 

Sign up for a free call for help with weight loss and other health issues: https://www.jayfeldmanwellness.com/call/ 

Timestamps:

0:00 – intro  1:20 – overview of FGF21 and how it gets triggered  6:40 – FGF21 works via stress, turning down metabolism and leading to weight regain  11:30 – will the sugar diet cause negative effects if only used short-term? 21:44 – does eating protein at night prevent the negative effects?  27:18 – the negative effects only occur in the research after long-term FGF21 upregulation

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/eb-133-the-sugar-diet-honey-diet-and-fgf21-the-research/

Timestamps:

0:00 – intro 

1:00 – the sugar diet, honey diet, fairy princess diet, and fruit-till-noon diets as discussed by Cole Robinson, Mark Bell, Anabology, Noah Ryan, celestialbe1ng, and others 

6:35 – my experience on a high-sugar diet and what the sugar diet means for the health world 

11:17 – what is FGF21? 

15:54 – how low-protein diets trigger the release of FGF21 

20:00 – the context of FGF21 on low-protein diets and the reasons for its effects: is this really beneficial? 

26:15 – the long-term effects of FGF21 on body fat, muscle mass, and metabolic health 

33:16 – how the sugar diet compares to low-carb diets 

35:55 – high-carb low-protein diets vs. high-fat low-protein diets on FGF21 

37:34 – low-protein diets increase your metabolism due to stress: brown fat, uncoupling, and energy expenditure 

43:59 – FGF21’s role in stress, energy conservation, and hibernation 

49:56 – FGF21 and cortisol: is FGF21 a stress hormone? 

54:09 – FGF21 and hormesis: is FGF21 hormetic? 

56:10 – FGF21 and liver fat production go hand-in-hand 

59:11 – carb-induced increase in FGF21 is activated by reductive stress 

1:05:04 – the role of FGF21 in de novo lipogenesis as an adaptive response to stress 

1:10:47 – carb-induced FGF21 causes fat gain and sympathetic activity 

1:14:29 – does FGF21 cause metabolic syndrome, diabetes, NAFLD, cardiovascular disease, and obesity? 

1:21:08 – does FGF21 extend lifespan? if so, is it worth it? 

1:27:03 – can you lose weight and extend lifespan without a protein-deficient diet?

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-132-youve-been-lied-to-about-fructose/

Timestamps:

0:00 – intro 

1:01 – Robert Lustig’s claims that fructose is a poison

5:50 – what Robert Lustig misses when it comes to glucose, the “good carbohydrate”

12:05 – what’s really responsible for the toxic effects of alcohol

16:53 – Robert Lustig's claim that fructose can’t be converted to glycogen is false [Robert Lustig’s fructose lies begin]

20:50 – whether fructose is inherently toxic in the liver

24:22 – the research showing that Robert Lustig is wrong about fructose

32:40 – whether fructose is really different from glucose in terms of its effects at the liver

35:51 – key factors missing in fructose research – endotoxin, PUFA, and rat research

41:22 – average fructose intakes are far below the amounts that are typically used in research

43:41 – whether Robert Lustig is right that fructose causes more fat production than glucose

49:35 – whether fructose (or carbs in general) cause fatty liver disease

52:15 –low-carb, high-fat diets trigger the exact mechanisms Dr. Lustig blames on fructose

1:00:59 – what really causes fatty liver disease

1:04:20 – should we avoid fructose-containing foods to fix fatty liver disease? Is soda and candy the answer?

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:44 – the brain's high energy demands and how metabolic dysfunction drives poor brain health

4:19 – are anxiety and depression caused by chemical imbalances in the brain?

7:05 – recognizing insulin resistance as an inability convert glucose to energy

9:42 – whether blood sugar spikes and crashes cause fatigue, brain fog, and psychiatric disorders

11:53 – our take on the Holistic Psychologist’s recommendations for stabilizing blood sugar

18:01 – what really interferes with brain energy metabolism – is it just sugar?

24:57 – refined sugar vs natural sugars such as honey, maple syrup, coconut sugar, and date syrup

30:55 – whether sugar is addictive

33:50 –fat triggers the same reward centers in the brain as carbohydrates

36:34 – how Jay & Mike fixed their sugar cravings from keto and low-carb

39:56 – whether eliminating starch is healthy long-term

44:34 – the negative impact of carnivore diets on gut health

50:16 – tips for recovering from the stress of carnivore and the importance of experimentation

53:46 – how much sugar and starch Jay, Mike, and Theresa eat

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Theresa's Instagram: https://www.instagram.com/livingrootswellness/

Timestamps:

0:00 – intro 

0:22 – meet Theresa Piela 

4:20 – emotional health as an underappreciated Bioenergetic factor 

11:03 – is Anthony Chaffee right about ketosis being our natural state? 

13:12 – is ketosis is the natural state for humans? 

18:57 – is ketosis is the natural state for animals? 

24:22 – whether bacteria can serve as a protein source in animals 

28:04 – whether ketosis is a natural healthy state rather than a starvation state 

32:11 – the potential benefits of ketones are misinterpreted as evidence that ketosis is ideal  

34:24 – the appeal of “naturalism” – just because something is natural, does that make it healthy? 

36:44 – is LMNT a scam? 

44:37 – whether we should always add electrolytes to our drinking water 

45:45 – Robb Wolf’s claim that insulin drives aldosterone production  

51:08 – stevia and allulose vs. sugar 

55:42 – whether we should be getting vitamin D from our food 

1:00:04 – how to properly supplement with vitamin D and the importance of calcium, magnesium, and vitamin K2 

1:04:18 – how vitamins E, K2, and A relate to vitamin D 

1:08:56 – the benefits of UVB and red light, and what to do to prevent aging skin 

1:14:19 – can applying cholesterol topically boost sun benefits?

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-131-whether-to-avoid-high-oxalate-foods-and-how-to-fix-oxalate-issues/

Timestamps:

0:00 – intro 

0:53 – whether fructose contributes to increased oxalate production 

3:42 – is sugar the culprit behind oxalate issues? 

9:14 – the problems with the research demonizing fructose 

14:45 – the optimal amount of dietary oxalate and how to determine whether oxalates are an issue for you 

17:57 – the importance of testing, experimentation, and listening to your symptoms 

25:10 – how to reduce your exposure to high-oxalate foods 

32:02 – the best cooking methods to reduce oxalates in food 

37:05 – foods highest in oxalates and whether salads are OK to eat 

40:17 – oxalate content in raw cacao vs chocolate 

45:26 – whether you need to avoid soybeans, potatoes, sweet potatoes, cassava, beets, and carrots due to their oxalate content 

49:05 – examples of bioenergetic diets with varying oxalate content 

57:01 – other dietary considerations for oxalate issues (PUFA, collagen, vitamin C, calcium, magnesium, carbohydrates, protein, and fat intake) 

1:06:22 – the best supplements to fix your oxalate issues  

1:11:45 – which supplements can make oxalate issues worse and whether to take probiotics for oxalate issues 

1:14:58 – the long-term impact of carnivore diets on liver and gut health

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-130-low-carb-diets-oxalates-the-surprising-connection/

Timestamps:

0:00 – intro 

1:06 – is there a daily limit to how much oxalate the kidneys can process? 

9:26 – whether we automatically store oxalates if they aren’t cleared through the kidneys 

13:40 – why mitochondrial function in the kidney is crucial for calcium oxalate crystal clearance 

17:30 – the benefits of citrate and whether it’s effective for clearing oxalates 

23:30 – whether baking soda (sodium bicarbonate) support the clearance of oxalates 

27:05 – how pH balance relates to oxalate clearance 

32:19 – is “oxalate dumping” real? 

43:06 – how low-carb diets increase oxalate absorption 

47:19 – whether having a small amount of oxalates helps prevent oxalate dumping 

50:02 – how low-carb diets increase oxalate absorption (cont.) 

52:19 – why low-carb diets like keto and carnivore may increase oxalate production relative to high-carb diets 

1:00:42 – how high-protein diets lead to increased endogenous oxalate production 

1:07:41 – how carbohydrates and insulin reduce oxidative stress and oxalate production 

1:11:40 – why glucose does not cause the formation of advanced glycation end products 

1:13:18 – how low-carb diets reduce oxalate clearance – stressed kidneys, lack of citrate intake, and more acidic blood & urine

Kitty's Instagram: https://www.instagram.com/kittyblomfield/?hl=en

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro 

0:38– how Kitty got introduced to Ray Peat 

3:59 – whether intermittent fasting is beneficial for women 

9:07 – the appeal of intermittent fasting and other restrictive diets, and why they do more harm than good 

14:41 – the truth about body recomposition: women are underfed and lack muscle 

17:29 – why low-carb diets like keto and carnivore are not sustainable 

19:36 – how mainstream health advice has ruined our diets and why we should eat like our grandparents 

25:21 – the role of stress in digestive health and the problem with jumping to supplements 

31:12 – when it makes sense to move on to more advanced health strategies such as lab testing, hormone replacement therapy, or gut protocols 

38:30 – Is Being Fat a Choice? Middle Ground by Jubilee 

41:23 – the relationship between emotional trauma, body image issues, and physical healing 

44:16 – what really influences body weight? 

53:30 – the importance of enjoying the food you eat daily and how it helps prevent binge eating 

55:25 – whether we should drink tons of water first thing in the morning 

57:35 – how much water do we really need? 

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-129-the-forgotten-source-of-oxalates-your-bodys-own-production/

Timestamps:

0:00 – intro 

1:12 – overview of endogenous vs. exogenous oxalates 

5:46 – how much oxalate comes from endogenous production vs. diet 

9:14 – when endogenous oxalate production matters more than dietary oxalate 

15:03 – rare genetic disorders that cause excessive oxalate production: primary hyperoxaluria 

22:36 – the pathways in the liver that lead to oxalate production 

32:41 – other biochemical pathways involved in endogenous oxalate production 

41:19 – deranged metabolic function as a primary driver of glyoxal production and lipid peroxidation 

45:14 – the extent to which glycine and vitamin C contribute to endogenous oxalate formation 

48:00 – how much does hydroxyproline contribute to oxalate production? 

52:06 – the primary precursor to oxalate that’s often ignored (glyoxal) 

55:08 – how oxidative stress drives oxalate production and how antioxidants help 

1:01:20 – what causes the high oxalate levels seen in type 2 diabetes, obesity, cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD)? 

1:11:16 – the protective effects of glycine in states of excess oxalate production 

1:15:54 – elevated stress hormones and gluconeogenesis increase oxalate production 

1:22:43 – nutrient deficiencies that contribute to oxalate issues (vitamin B1, vitamin B6, and zinc)

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro

0:48 – Peter Attia admits he was wrong about fasting after 10 years of muscle loss 

4:00 – the importance of critical thinking and whether it's okay to change your mind 

11:46 – why experimentation should be guided by sound logic 

18:06 – whether supplementing with BCAAs (branched-chain amino acids) while fasting prevents muscle loss 

20:58 – the long-term cost of fasting and relying on adrenaline for energy and focus: impaired cognition, thyroid, testosterone, digestion, and more 

30:19 – Peter Attia says there’s no benefit to fasting beyond calorie restriction – is reduced protein intake the only drawback? 

38:34 – the problems with traditional education, where memorization replaces true learning 

41:03 – whether fasting is optimal because our ancestors fasted 

45:32 – whether evolution is purely random and whether we should mimic our ancestors 

51:58 – the cumulative effects of fasting and high stress hormones (anxiety, insomnia, low body temperature, weakened immune function) 

54:09 – whether methionine restriction is recommended to increase lifespan 

1:03:08 – the importance of consuming more gelatinous, collagen rich cuts of meats  

1:06:03 – the benefits and possible drawbacks of supplementing with glycine and taurine 

1: 10:53 – how to properly use taurine for bile acid stimulation 

1:16:33 – Anthony Chaffee disagrees with Paul Saladino on fructose – is fructose just alcohol without the buzz? 

1:23:11 – whether fructose is broken down into the same byproducts as alcohol 

1:30:01 – the difference between fructose and alcohol metabolism in the liver 

1:35:10 – whether fructose increases de novo lipogenesis and contributes to fatty liver disease 

1:44:43 – the problems with trusting medical advice based on appearance and authoritative stance, and how to discern credible sources 

1:51:04 – critiquing Paul Saladino’s take on the benefits of nitric oxide 

1:55:43 – the cost of organ transplants 

1:57:32 – optimizing gut motility, relieving constipation, and how fiber can help with protein and fat digestion 

2:04:03 – how dining out at restaurants can hinder progress and impede healing 

2:08:30 – how even high-end restaurants use toxic cooking oils and reasons to avoid aged meat 

2:12:44 – strategies for avoiding toxic foods in social settings and while traveling 

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-128-are-oxalates-the-problem-or-is-it-your-gut/

Timestamps:

0:00 – intro 

1:08 – common misconceptions about oxalates and whether oxalate concerns are justified

5:21 – symptoms often attributed to oxalates and whether they are truly responsible for most health problems

12:48 – what are oxalates? 

16:18 – oxalates cause kidney damage and reduce mineral bioavailability

21:34 – oxalates and cardiovascular disease

24:43 – oxalates as a driver of gut dysbiosis and decreased bile acid production

29:16 – metabolic damage caused by oxalates

37:06 – how a low-PUFA diet and vitamin E can protect against oxalate damage

43:19 – high oxalate foods and factors that impact oxalate absorption

53:29 – soluble vs. insoluble oxalates

57:04 – how calcium affects oxalate absorption and the impact of parathyroid hormone and 1,25-Dihydroxyvitamin D

1:07:41 – the effects of magnesium on oxalate absorption

1:12:44 – how deficiencies in vitamin B1 (thiamine) and vitamin B6 can increase oxalate levels

1:14:44 – how gut health relates to oxalate issues (fat digestion, intestinal permeability, and oxalate degrading bacteria)

1:22:23 – “oxalate dumping” on low-carb diets and carnivore diets may be due to poor gut health

1:26:15 – whether candida infections or other fungal infections cause excess oxalate production

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro

1:46 – Gabrielle Lyon promotes bro science: 1 gram of protein per pound of bodyweight 

7:15 – problems with high-protein diets – stress hormones, low testosterone, slowed metabolism, and gut toxins

15:21 – whether studies on Eskimo and Inuit populations support a high-protein diet

16:59 – the problems with Gabrielle Lyon’s recommendation of a 1:1 protein to carbohydrate ratio

23:48 – the minimum amount of carbs we need daily and the consequences of not getting enough

26:56 – Gabrielle Lyon is confused about fats

35:43 – types of fats commonly used in bodybuilding and whether they’re truly optimal

37:37 – Dr Boz’s recommendations for high blood sugar on carnivore and OMAD (one-meal-a-day)

45:59 – the drivers of high fasting blood glucose on low-carb diets

49:38 – whether overeating is really an issue on the carnivore diet and why increased appetite signals improved health

57:28 – whether Dr. Boz's recommendation to shift the eating window earlier has any validity

1:01:33 – Sean Baker’s shift away from the carnivore diet

1:03:31 –Dr Boz denies that the carnivore diet caused increased fasting blood sugar

1:11:16 – why Dr Berg is wrong – serotonin is not the “happy hormone”

1:20:40 – the idea that low serotonin causes depression and high serotonin reverses it is unsupported

1:23:05 – our thoughts on Dr. Berg's recommendations for raising serotonin: exercise, fasting, and tryptophan

1:28:46 – whether vitamin D increases serotonin

1:30:56 – the benefits of sunlight and red-light exposure

1:39:39 –the problems with Glucose Goddess’s strategies to prevent blood glucose spikes

1:49:22 – insulin and blood sugar spikes are misunderstood

1:54:46 – how an excessive focus on blood glucose and insulin misses the underlying issues

1:55:59 – is obesity primarily caused by genetics?

2:01:49 – whether diet and exercise impact obesity rates

2:09:26 – the vital importance of finding fulfillment in life, following our passions, and escaping the grind of the rat race

2:15:12 – what it really takes to be healthy and whether it's possible to improve your health without expensive interventions

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-127-lipolysis-and-fat-loss-lose-body-fat-without-increasing-fat-burning/

Timestamps:

0:00 – intro

1:08 – the fat loss narrative: release more fat from your fat stores through intense exercise, fasting, cold plunges, and low-carb diets

4:08 – how fat gets released from our fat stores

8:40 – the baseline rate of fat release from our fat stores and the impact of degenerative states like cancer on lipolysis

12:09 – how fat is released from our fat stores in response to stressors like exercise

15:34 – the connection between lipolysis, metabolic syndrome, and fatty liver disease

23:29 – the research showing that decreasing lipolysis leads to less body fat (not more)

33:47 – whether we want to block hormone-sensitive lipase (HSL) activity

37:47 – the research showing that increasing fat burning and lipolysis does not increase fat loss

44:25 – how to lose body fat without relying on stress-driven fat oxidation

49:56 – strategies for fat loss without increased lipolysis: are exercise, fasting, and cold plunges the solution?

Analyze & Optimize's Website: https://www.analyzeandoptimize.io/

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro 

0:38 – how Analyze & Optimize (Jack & Dalton) got introduced to work of Ray Peat 

6:32 – how Analyze & Optimize create their videos 

10:40 – refuting Robert Lustig's claims – is fructose as harmful to the liver as alcohol? 

17:40 – whether Analyze & Optimize are paid by “big sugar”  

20:30 – Robert Lustig’s fructose claims are unsupported 

28:06 – is white sugar safe to consume? 

33:04 – Serotonin & Hierarchy by Jordan Peterson 

34:33 – SSRI use and serotonin’s role in promoting learned helplessness and anhedonia 

40:46 – how the perceived benefits of serotonin could be attributed to other factors 

45:45 – whether serotonin is the “dominance” hormone 

47:17 – Analyze & Optimize respond to Shawn Baker on sugar cravings being a sign of health and youth 

51:04 – declining health on the carnivore diet, whether it’s sustainable, and why your immune system needs carbohydrates 

54:04 – carnivore diet effects on gut health – quorum sensing, biofilms, high stress hormones, and damage to thyroid health 

1:01:30 – why chronic low-calorie intake turns down metabolic function and leads to obesity 

1:07:00 – the harm caused by conflating progesterone and synthetic progestins 

1:14:57 – the link between birth control and cancer and the protective effects of progesterone 

1:18:20 – the negative effects of synthetic progestins and estrogen, especially unchecked by natural progesterone 

1:24:45 – Why Is the Right So Obsessed with Seed Oils? by Ej Dickson 

1:31:15 – Dave Asprey argues with Paul Saladino on supplements vs orange juice 

1:39:10 – whether Ray Peat’s ideas and principles promote orthorexia 

1:44:22 – using precision medicine vs. listening to your body 

1:51:09 – where to find more of Jack & Dalton’s work 

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-126-high-triglycerides-on-a-high-carb-diet-should-you-be-worried/

Timestamps:

0:00 – intro

1:10 – whether elevated triglycerides on a high-carbohydrate diet warrant concern 

3:21 – the association between LDL, cardiovascular disease, and metabolic syndrome 

5:52 – the lipid energy model and what accounts for the lipid values seen in Lean Mass Hyper-Responders (LMHR)  

9:26 – what causes higher triglycerides seen on higher-carb, lower-fat diets in someone who is insulin sensitive 

11:39 - what causes high triglycerides in insulin resistance 

18:08 – are elevated triglyceride levels on a high-carb diet concerning, and do they drive cardiovascular disease? 

24:08 – whether small, dense LDL and low HDL levels drive heart disease 

28:25 – native cultures showing high triglycerides on a high-carb diet with no signs of cardiovascular disease:Tarahumaras, Tukisenta, and the Kitavans 

34:10 – high-carb diets support insulin sensitivity and don’t increase uric acid levels in the Tukisenta  

37:23 –high-carb diets support insulin sensitivity without increased activity levels in the Kitavans 

43:43 – when elevated triglycerides might become a concern after increasing carbohydrate intake 

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro

0:28 – Andrew Huberman and Layne Norton on whether seed oils are inherently harmful

4:18 – why Layne Norton's "calories-only" view is flawed, as it ignores how the type of food actually affects our bodies

9:58 – whether animal studies are useful in nutritional research, or if only human randomized control trials (RTC) should be considered

15:57 – problematic assumptions and biases in nutritional research and how they can shape research outcomes

20:59 – why the reported health benefits of polyunsaturated fats in research are misleading and harmful

26:54 – the connection between chronic disease and polyunsaturated fats, and how focusing solely on calories relieves the food industry of responsibility for health outcomes

31:43 – Liver King's self-esteem, body image struggles, steroid use, health risks, and why his apology was commendable

41:36 – why cultural standards for physical appearances are unrealistic, unhealthy, and can lead to conflating steroid-enhanced bodies for genuine health

51:12 – health risks associated with steroid-use and having too much muscle mass

1:00:34 – Thomas Delauer and Derek from moreplatesmoredates discuss omega-3s

1:06:21 – whether the antioxidants in fish oil are worth the damage caused by lipid peroxidation

1:10:54 – whether cod liver oil is any better than fish oil

1:17:11 – how to effectively hydrate your cells and the importance of getting enough salt

1:24:44 – why consuming a lot of plain water without electrolytes actually impairs hydration, contributing to increased swelling, increased stress, and impaired energy production

1:32:38 – the importance of getting adequate potassium in addition to salt intake

1:38:03 – factors that may increase your need for water

1:40:02 – what Ben Bikman misses when it comes to blood glucose and insulin resistance

1:48:15 – the true relationship between insulin and blood sugar regulation

1:54:30 – Ben Bikman misapplies this study: it does not support that carbohydrates cause insulin resistance

2:00:38 – creating content in the health sphere, choosing high quality foods, and the benefits of tracking food (using Cronometer or another similar app)

• Whether estrogen is just a reproductive hormone
• Whether you need to be concerned about testosterone converting to estrogen
• How you can have excess estrogen production even after menopause
• The best way to use progesteron
• Whether Calcium D-glucarate is effective for lowering estrogen

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-124-forget-about-cico-a-smarter-approach-to-fat-loss/

Timestamps:

0:00 – intro 

1:07 – our thoughts on Wendy Sellens’ recent interviews with the Strong Sistas (Ashley and Sarah Armstrong) 

6:30 – the importance of reviewing research with an open mind, avoiding any rigid or authoritative stance 

9:38 – whether all research should be rejected due to Rockefeller funding and whether Dr Ray Peat was “Rockefeller trained” 

15:47 – whether reproductive hormones affect only reproductive organs 

20:35 – how hormonal imbalances affect all areas of health—reproduction, digestion, edema, bloating, cancer risk, weight gain, brain health, bone health, and muscle growth 

23:38 – whether Dr Hobbins’ experiments proved that there are no receptors for reproductive hormones in non-reproductive organs 

26:51 – why Wendy’s claim—that the rise in estrogen during pregnancy is caused by exogenous compounds (phytoestrogens and xenoestrogens)—is incorrect 

29:29 – estrogen’s role as a growth-promoting hormone and how progesterone counterbalances it by promoting cellular differentiation 

35:47 – whether testosterone can be converted into estrogen 

36:52 – how you can have excess estrogen production even after menopause and problems with estrogen testing 

40:19 – body fat as a major source of estrogen 

44:33 – why Wendy’s claim that calcium D-glucarate increases estrogen is incorrect 

46:56 – the mechanism through which calcium D-glucarate effectively lowers estrogen levels 

50:28 – confounding variables that make it difficult to accurately interpret the results of breast thermography scans 

• The criticism of Georgi regarding estrogen and cancer
• The major point that Siim Land is missing when it comes to increasing NAD+
• Why we think Dr. Berg is completely wrong on serotonin
• Nutrition With Judy’s suggestion that thyroid issues on a carnivore diet are not caused by the lack of carbohydrates, and why we think this isn’t the case
• Dave Asprey’s recommendation to drink orange juice and whether it’s for the right reasons

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro

1:10 – whether estrogen is a carcinogen 

6:13 – estrogen’s role in driving weight gain and chronic diseases such as cancer, Alzheimer’s disease, and Type 2 Diabetes 

8:03 – the dangers of synthetic progesterone (progestin) use 

10:14 – the difference between estrone and estradiol and the problems with estrogen testing 

16:14 – whether estrogen therapy should be used in post-menopausal women 

17:17 – the difference between oral and transdermal estrogen use 

24:44 – the connection between inflammation and estrogen production 

27:57 – why estrogen levels are not actually low in post-menopausal women 

37:59 – our take on Siim Land's post on NAD+ and mitochondrial uncoupling 

48:25 – why intentionally seeking hormetic responses, like the activation of heat-shock proteins, should be avoided 

50:37 – which form of CoQ10 is better: ubiquinone or ubiquinol 

53:34 – what Siim Land and many others get wrong when it comes to raising NAD+  

55:44 – does fasting and AMPK upregulation cause cancer? 

1:00:29 – fat fuels cancer and why not to restrict sugar for cancer 

1:09:56 – Dr Berg’s take that serotonin is the “happy hormone” – why we disagree 

1:19:06 – serotonin’s role in driving chronic diseases and conditions including depression, anxiety, IBS, and cancer 

1:27:24 – Nutrition with Judy claims that the low thyroid levels generally seen on the carnivore diet have nothing to do with a lack of carbohydrates 

1:39:01 – how the rate of living theory changed mainstream medicine’s view that thyroid health is important 

1:45:37 – how excessive exercise raises stress hormones, setting you up for weight regain 

1:51:30 – why the combination of fasting and exercise is detrimental to our health 

1:53:44 – how estrogen is used to fatten animals  

2:02:42 – why Dave Asprey is talking about endotoxin and orange juice 

2:07:00 – whether the sugar in orange juice feeds bacteria and increases endotoxin 

2:09:40 – why the low-carb trend keeps resurfacing, despite the growing evidence against it 

2:14:41 – where to find Georgi and IdeaLabs 

• An alternative framework to CICO for conceptualizing fat loss
• Why eating less and exercising more is not the best solution for fat loss
• Why excess energy does not cause fat gain and instead leads to fat loss
• How you can get stuck in a cycle of weight gain, undereating, and constant hunger, and how to get out of that cycle

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-124-forget-about-cico-a-smarter-approach-to-fat-loss/

Timestamps:

0:00 – intro

1:06 – recapping the problems with CICO

5:02 – the Energy Balance approach as an alternative to CICO for fat loss

12:12 – why calories do not equal energy and considering the possible fates of the food we consume

17:39 – efficient mitochondrial function as a central piece that determines whether substrate will be stored as body fat

19:39 – the amount of food you eat does matter

21:46 – conceptualizing Energy Balance with numerical units

24:00 – fat gain as a consequence of impaired mitochondrial function

29:01 – how you can lose fat while eating more

33:12 – the effects of energy availability on hunger and stress hormones

36:41 – how stress hormones, along with energy deficits, cause the body to break down muscle, bone, and skin for energy

43:16 – the benefits of having an energy surplus: improved sleep, immune function, digestion, cognitive function, and more

46:20 – comparing the Energy Balance approach with CICO and the major cost of the advice to “eat less and exercise more

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro

0:36 – catching up: fruit quality in the Philippines and Ecuador, and the effects of mold toxicity

5:28 – Kiran Krishnan and Nutrition with Judy discuss why they believe coconut oil should not be consumed

9:55 – whether coconut oil causes greater release and absorption of endotoxin (LPS)

12:11 – should you eat coconut oil even if your ancestors didn't?

21:08 – how MCT oil compares to coconut oil as it relates to the microbiome

32:28 – concerns with adopting dietary ideologies

36:21 – Morley Robbins on why the thyroid doesn’t run the body and we shouldn’t ignore the adrenals

47:05 – adrenal fatigue as a systemic issue and whether the thyroid or adrenals run the body

56:45 – our take on Real Food Gangsta’s (Josh & Jeanne Rubin) view that the adrenal glands regulate the body’s mineral and fuel availability

1:07:02 – the importance of optimal gut motility and how to alleviate gut motility issues such as constipation and loose stools

1:19:54 – which lab tests provide the most valuable information

1:25:14 – the benefits of spending time without stimulation (letting your mind wander) during the day

1:27:20 – simple mindset strategies to help you reach your goals

1:32:55 – Alan Aragon’s argument that not all seed oils are harmful

1:40:56 – why the claim that seed oils lower cholesterol does not mean they are healthy

1:42:25 – whether animal studies are valuable for understanding the effects of seed oils on human health

• Whether “calories in, calories out” is physiologically accurate
• The many misconceptions related to “calories in, calories out”
• Why a calorie deficit is NOT required for fat loss
• Why “calories in, calories out” does not mean that eating less and exercising more is good advice for fat loss
• What most people miss when it comes to “calories in, calories out”

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-123-debunking-the-cico-myth-calorie-deficits-are-not-required-for-fat-loss/

Timestamps:

0:00 – intro

1:07 – questions about the calories-in, calories-out (CICO) model of weight loss that I’ll be answering 

7:18 – what is (and isn’t) a calorie? 

11:49 – misapplications of CICO and why CICO is not physiologically accurate in the ways most people use it 

19:46 – why the idea that “a calorie is a calorie” is misleading 

29:11 – how energy in food is measured and the inaccuracy of food labels 

36:16 – the impact of behavioral compensation and metabolic adaptation on energy expenditure 

42:07 – how cutting calories lowers metabolism, reduces thyroid function, and increases stress hormones, appetite, and weight regain 

48:26 – Herman Pontzer’s Constrained Model of Energy Expenditure and the adverse effects of energy deficits 

52:21 – whether CICO can accurately represent physiology 

1:00:04 – a simplified version of CICO 

1:05:41 –why calories do not equal usable energy or weight 

1:13:27 – examples demonstrating the issues with common CICO misconceptions 

1:21:09 – summarizing the central issues with CICO and how you can lose body fat without a caloric deficit 

1:28:13 – whether there’s value to CICO

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Danny's Telegram: https://t.me/dannyroddy

Timestamps:

0:00 – intro

0:33 – why we started this podcast

6:25 – our take on Bryan Johnson’s Longevity Blueprint and problems with biohacking

12:13 – whether we should adopt any of the strategies from Bryan Johnson’s Blueprint to achieve optimal health

14:50 – the cost of continually being in a caloric deficit and why this does not increase longevity

21:06 – issues with eating hard-to-digest foods and whether supplements can make up for missing nutrients in the diet

22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits

28:00 – potential pros and cons of Bryan Johnson’s Blueprint and how to measure health

32:39 – Bryan Johnson’s supplement protocol

41:09 – how low-carb diets negatively affect NAD+ to NADH ratios and estrogen status

46:20 – whether body fat percentage and cholesterol levels can be too low

52:20 – what is stress?

1:03:20 – issues with hormesis and the idea that stress is beneficial

1:07:34 – whether avoiding stress is possible and how to develop resilience to stress

1:13:17 – addressing Marty Kendall’s response to our take on glucagon and insulin

1:24:17 – glucagon’s short-term and long-term effects on metabolic function

1:26:46 – glucagon’s role in insulin resistance and type 2 diabetes

1:37:16 – metabolic dysfunction as a driver of insulin resistance

1:41:06 – whether we need to be concerned about wasting energy on hormone production

1:44:50 – whether we should always try to avoid gluconeogenesis

1:51:45 – how to use carbohydrates to stabilize your blood sugar

1:56:11 – habit stacking, simplifying supplementation, and adopting a long-term mindset when it comes to health

• Whether Berberine and Urolithin A are good options for weight loss
• How Berberine lowers your blood sugar and whether this is really a good thing
• The effects of Berberine and Urolithin A on your gut
• Whether you always need to avoid blood sugar spikes
• Whether you always need to have protein with your carbohydrates

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-122-weight-loss-with-berberine-and-urolithin-a-blood-sugar-spikes-and-pairing-protein-with-carbs-qa/

Timestamps:

0:00 – intro

1:10 – what are berberine and urolithin A?

2:26 – the benefits of berberine on gut health

9:06 – berberine as a mitochondrial poison and the mechanisms of berberine’s toxicity and blood-sugar-lowering effects

13:13 – of the effects urolithin A on mitochondria and the gut

18:15 – whether urolithin A is beneficial for weight loss and increases brown adipose tissue activity

22:13 – the importance of avoiding reductionistic thinking around supplements touted for weight loss benefits

26:31 – powerful weight loss strategies that are simple and effective, without supplementation

31:02 – whether we always need to avoid blood sugar spikes and dips

35:30 – when having protein alongside carbs is necessary and why increasing carbohydrate intake improves insulin sensitivity, even in people with type 2 diabetes

40:49 – how fat, fiber, and protein help slow the absorption of carbohydrates and improve blood sugar management

46:20 – issues with grain-based carbs and the importance of finding carb sources that work for you

• How to fix adrenal fatigue and adrenal insufficiency and whether these are really adrenal problems
• Whether it makes sense to use desiccated adrenal products or hydrocortisone for adrenal fatigue
• How the GAPS diet can resolve autoimmune issues and whether you should consider trying it
• How to improve fat digestion and bile flow
• How to improve digestion without a gallbladder

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-121-how-to-address-adrenal-fatigue-gaps-diet-concerns-and-gallbladder-health/

Timestamps:

0:00 – intro

1:13 – what is adrenal insufficiency and what causes it?

7:02 – what is adrenal fatigue and how can we reverse it?

11:54 – the drivers of adrenal fatigue and issues with typical treatments

18:51 – the importance of establishing solid diet and lifestyle foundations before adding supplements for adrenal support

24:42 – whether our bodies lose the ability to produce hormones as we age

27:20 – concerns with the use of natural supplements like desiccated adrenal glandulars, licorice, and hormone replacement therapy (HRT)

36:07 – whether the GAPS diet is ideal for healing autoimmune conditions

40:01 – problems with the GAPS diet and other elimination diets

47:37 – the importance of individualizing your gut protocol and the problems with a cookie-cutter approach

52:09 – the connection between gut health, stress hormones, mental health, and autoimmunity

55:40 – how to improve digestion without a gallbladder

59:13 – common issues seen in those without a gallbladder

1:02:08 – long-term consequences of gallbladder removal and how to heal gallbladder issues

1:05:30 – when to use ox bile, TUDCA, taurine, glycine, or vitamin C

1:09:16 – how much fat to include in your diet to stimulate bile flow, and what types of fats are optimal

1:12:55 – strategies for preventing and resolving bile dumping and reflux

1:15:44 – additional consequences of gallbladder removal

1:17:36 – gallbladder issues in relation to hypothyroidism and estrogen dominance

• The research behind vitamin A toxicity and whether vitamin A is really a poison
• Whether you need to be concerned about the use of Accutane
• Whether retinoic acid is toxic because it’s used as a chemotherapeutic agent
• Whether Grant Genereux’s claims about vitamin A toxicity are valid

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-120-vitamin-a-toxicity-retinoic-acid-toxicity-accutane-and-whether-hypervitaminosis-a-exists

Timestamps:

0:00 – intro

1:15 – why we're examining Grant Genereux's take on vitamin A toxicity and the evidence behind his claims

4:50 – conceptualizing the amount of vitamin A needed for toxicity

7:07 – is hypervitaminosis A (vitamin A toxicity) real?

9:27 – cautioning against the idea of "detox" as an excuse for negative effects and vitamin A toxicity as an unfalsifiable hypothesis

12:36 – is there a conspiracy to poison the masses with vitamin A?

18:36 – how likely is it that you have vitamin A toxicity?

22:30 – problems with the first in vivo study that Grant uses to support vitamin A toxicity

35:14 – vitamin A toxicity in the studies Grant cited require massive doses of vitamin A that would be impossible to obtain from diet

42:44 – Grant’s cited research actually supports the safety of vitamin A

50:52 – more of Grant’s cited research supporting vitamin A safety

58:25 – further research supporting that extremely high doses are required to cause vitamin A toxicity

1:07:57 – whether vitamin A toxicity is driving autoimmunity

1:09:54 – whether retinoic acid is toxic based on concerns regarding the use of Accutane 

1:15:40 – how conflating Accutane with retinoic acid is misleading 

1:22:12 – whether retinoic acid is toxic because Accutane is used as a chemotherapeutic agent 

1:29:37 – evaluating Grant’s claim that retinol automatically becomes “toxic” retinoic acid 

1:35:05 – our concluding thoughts on Grant’s arguments regarding vitamin A toxicity

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-119-vitamin-a-toxicity-examining-the-evidence-for-vitamin-a-deficiency

Timestamps:

0:00 – intro

1:09 – why we’re discussing vitamin A toxicity and Grant Genereux’s perspective

4:53 – closedmindedness within the “low vitamin A” sphere and how it compares to Ray Peat’s work

7:33 – how a low vitamin A diet can have benefits

9:27 – cautioning against the idea of "detox" as an excuse for negative effects and vitamin A toxicity as an unfalsifiable hypothesis

12:33 – the importance of evaluating information objectively while avoiding censorship, tribalism, fearmongering, and religiosity

21:17 – concerns with the current state of the Ray Peat Forum and how to recognize unsubstantiated claims

26:45 – Grant's initial critiques of the original studies on vitamin A deficiency are extremely weak and unsubstantiated

41:48 – introducing Wolbach’s 1925 study on vitamin A deficiency

45:47 – refuting Grant's argument that the retinoic acid in the vitamin-free casein would have caused toxicity

52:35 – refuting Grant's argument regarding confounding variables in lard and butter

1:02:53 – research on vitamin A deficiency and whether vitamin A deficiencies exist

1:20:32 – the necessity of vitamin A for pregnancy, fetal growth, and development

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-118-the-truth-about-serotonin-and-ssris-why-serotonin-is-not-the-happy-hormone

Timestamps:

0:00 – intro

0:58 – the research showing that serotonin is not the “happy hormone”

4:56 – serotonin’s role in driving the stress state that leads to depression

8:26 – the overlap between anxiety and depression and why they are both characterized by elevated serotonin levels

10:27 – the origins of the idea that serotonin is the “happy hormone” and how serotonin became a marketing tool for pharmaceutical companies

14:49 – serotonin is increased during fasting and starvation and why increasing serotonin should not be our goal

20:16 – serotonin is increased during stress, shock, and infection and leads to learned helplessness

29:04 –SSRIs use in neonates causes depression in adulthood

31:35 – the serotonergic system as an adaptive stress response to a lack of energy

39:09 – serotonin’s role in energy redistribution under stress

43:15 – how SSRIs inhibit mitochondrial respiration, glucose metabolism, and energy production in the brain and liver

47:13 – how SSRIs can reduce symptoms and how the brain responds to SSRIs

52:42 – the true drivers of depression and anxiety

1:01:30 – how serotonin relates to stress hormones, including cortisol, and energy balance

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-117-fructose-malabsorption-protecting-against-alcohol-and-brain-injuries-and-inflammation-q-and-a

Timestamps:

0:00 – intro

1:15 – how fructose gets absorbed in the small intestine

4:24 – the optimal fructose to glucose ratio and how to tell if you have fructose malabsorption

8:41 – the details of how glucose helps with fructose absorption

12:04 – which foods have a high fructose to glucose ratio

16:24 – issues with FODMAP categorization and whether fructose is really a FODMAP

21:23 – listening to your body and understanding individual context vs following rigid “food rules”

27:39 – anti-inflammatory diets and whether we should avoid sugar and supplement with fish oil to reduce brain inflammation

32:06 – dietary and supplement strategies to promote an anti-inflammatory state in the brain

39:15 – the effectiveness of red-light therapy, methylene blue, progesterone, exogenous ketones, and polyphenols in treating brain injuries

44:31 – why we don’t want to prioritize omega 3s in the diet and whether eating fish is any better than fish oil supplementation

47:21 – reducing inflammation with the use of aspirin

47:53 – the main concerns with drinking alcohol: intestinal permeability, endotoxin production, and liver health

52:32 – stress-relieving supplement alternatives to alcohol and the effects of alcohol on vitamins and minerals

54:37 – strategies to mitigate the effects of alcohol in the short-term

58:14 – whether it makes sense to drink alcohol, alcohol use as a coping mechanism, and the impact of culture

1:00:07 – more strategies for mitigating the effects of alcohol in the short and long term

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-116-the-truth-about-ldl-and-heart-disease-lmhr-and-the-lipid-energy-model/

Timestamps:

0:00 – intro

1:17 – the primary counterarguments against the Lipid Energy Model 

4:15 – BMI, not saturated fat, correlates with the LMHR phenotype 

8:15 – eating carbs dramatically lowers cholesterol in LMHR 

11:14 – whether Oreos are more effective at lowering cholesterol than statins 

17:30 – high cholesterol levels in the LMHR phenotype are not due to excess saturated fat intake or cholesterol production 

19:25 – prominent cardiologists and researchers dismissing the lipid energy model due to dogmatism interferes with progress in science and medicine 

24:40 – Dr. Shawn Baker’s carbohydrate experiment and contextual considerations when reintroducing carbs into the diet 

28:46 – further support for the lipid energy model and the relationship with thyroid function 

33:32 – the difference between saturated, monounsaturated, and polyunsaturated fats in relation to lipid profiles 

34:40 – whether LDL cholesterol and ApoB cause heart disease and plaque formation 

42:18 – how the Lipid Energy Model helps uncover the underlying cause of heart disease 

45:15 – LDL levels as a marker of metabolic health rather than a cause of cardiovascular disease and why we may not always want to lower LDL 

55:02 – evidence suggesting that LDL does not drive cardiovascular disease 

1:05:43 – the difference between high LDL due to metabolic dysfunction and high LDL due to a low-carb diet 

1:09:58 – lipid values don’t tell us the whole picture: the Kitavans 

1:16:54 – why decreases in insulin, glucose, and HbA1C as well as increased lipolysis and fat oxidation on a low-carb diet is not necessarily a sign of improvement 

1:22:57 – increased lipolysis on low-carb diets does not lead to body-fat loss 

1:24:25 – whether the Lipid Energy Model proves that low-carb diets are optimal for health

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-115-lmhr-and-the-lipid-energy-model-implications-for-metabolism-and-hormones

Timestamps:

0:00 – intro

1:14 – what is the Lean Mass Hyper-Responder (LMHR) phenotype

3:33 – how the Lipid Energy Model challenges the mainstream dogmatic view linking high cholesterol levels to heart disease

6:33 – the protective effects of cholesterol and why it does not cause heart disease, despite being necessary for atherosclerosis

9:49 – the distinction between Lean Mass Hyper-Responders and those with high cholesterol levels in the context of metabolic dysfunction

15:10 – what is the Lipid Energy Model

22:10 – how the body adapts to a lack of carbohydrates, leading to elevated cholesterol levels

27:22 – the hormonal and metabolic state underlying the Lean Mass Hyper-Responder phenotype

32:21 – how adding carbohydrates lowers cholesterol levels in those who don't have metabolic dysfunction at a cellular level

37:11 – whether Lean Mass Hyper-Responders are at increased risk of cardiovascular disease

42:00 – why the Lean Mass Hyper-Responder phenotype isn't ideal: stress and low thyroid function

51:10 – the parallels between the lipid energy model and physiological insulin resistance

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-114-fat-burning-drives-insulin-resistance-and-eating-carbohydrates-improves-insulin-sensitivity/

Timestamps:

0:00 – intro

1:17 – stress hormones (glucagon, epinephrine, and cortisol) are major contributors to insulin resistance and diabetes 

4:05 – elevated glucagon levels, not carbohydrates, are the driving force behind high fasting blood glucose levels

6:43 – glucagon is a driver of insulin resistance, while insulin is just a symptom

12:46 – the research showing that blocking stress hormones directly improves insulin sensitivity

15:14 – “hormetic” stressors like intermittent fasting, cause insulin resistance

19:30 – fat burning drives insulin resistance and keeps us in a catabolic state, driving weight gain and muscle wasting 

22:15 – cortisol drives insulin resistance and why serum cortisol levels don’t provide the full picture

25:00 – low-carb diets reduce insulin sensitivity while carbohydrate intake improves it 

29:40 – decreasing fatty acid oxidation by increasing carb intake improves our ability to tolerate carbohydrates

33:46 – burning fat contributes to increased disease processes and does not lead to losing more body fat

38:04 – fatty acid oxidation damages our mitochondria and increases fat storage

46:22 – type 2 diabetes directly contributes to heart disease by upregulating fatty acid oxidation 

52:05 – how to decrease fatty acid oxidation and improve glucose metabolism

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-113-carbohydrates-dont-cause-insulin-resistance-or-diabetes-evidence-for-the-bioenergetic-view

Timestamps:

0:00 – intro

1:28 – what the mainstream view of insulin resistance gets wrong when it comes to what causes insulin resistance and diabetes

3:24 – glycolysis and fat oxidation are favored, and glucose oxidation is inhibited in insulin resistance and diabetes

8:39 – what happens to glucose in diabetic cells

10:32 – why insulin resistance is a symptom rather than the driver of diabetes

12:55 – research showing that insulin resistance is driven by poor glucose metabolism

20:50 – impaired glucose uptake is not caused by excess insulin; fat-burning and impaired glucose metabolism are the culprits 

27:10 – the problems with relying on fat oxidation over carbohydrate oxidation 

30:43 – how increasing blood glucose levels or increasing insulin can restore normal glucose uptake in diabetes

35:28 – how insulin actually lowers blood sugar and the effects of insulin on cortisol and other stress hormones

37:16 - why fatty acid oxidation is NOT the underlying cause of insulin resistance

40:06 – factors that support or block mitochondrial respiration

41:20 – how excess fatty acid oxidation contributes to the pathology of insulin resistance and can impair glucose metabolism over time

42:49 - how insulin actually lowers blood sugar and the effects of insulin on cortisol and other stress hormones (cont.)

47:08 – why we don’t want to blame insulin for insulin resistance and what really causes high fasting blood glucose

49:22 – how low-carb diets increase stress hormones and decrease insulin sensitivity

Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide

Free Energy Balance Mini-Course: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-112-the-problems-with-resistant-starch-and-balancing-the-calcium-to-phosphorus-ratio-qa

Timestamps:

0:00 – intro

1:00 – mainstream health claims about resistant starch and why we disagree

6:15 – whether there are any benefits to including resistant starch in your diet

11:07 – how to tell if resistant starch is negatively impacting your gut health and how to avoid it

16:05 – which starches are easiest to digest and the factors that affect our ability to digest starches optimally

21:38 – why we should pay attention to our calcium to phosphorus ratio and the risks of high parathyroid hormone levels

26:19 – the optimal calcium to phosphorus ratio and the calcium paradox in terms of regulating blood pressure 

31:21 – which phosphorus-containing foods we should avoid to optimize bone density 

34:36 – the calcium paradox and why consuming calcium doesn’t increase intracellular calcium

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

The Nutrition Blueprint: https://mikefave.com/the-nutrition-blueprint/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-111-stevia-vs-sugar-ketogenic-diets-for-epilepsy-and-spore-based-vs-standard-probiotics-qa

Timestamps:

0:00 – intro

1:17 – whether spore-based probiotics can cause bacterial overgrowths like SIBO

4:53 – the drawbacks of standard probiotic use and the limitations of stool testing

9:55 – how spore-based probiotics protect against pathogenic bacteria and endotoxin and which spore-based product Jay recommends

15:39 – long-term benefits of spore-based probiotics and how long you need to use them for these benefits

21:05 – whether low-carb or ketogenic diets are necessary to improve epilepsy 

29:25 – using ketones for fuel and why the production of ketones isn't the problem on a ketogenic diet 

30:48 – the main drivers of epileptic seizures and how ketones help to prevent or reverse them 

34:17 – the role of the gut microbiome in brain health and epilepsy

42:18 – concerns with low- or no-calorie sweeteners like stevia

48:03 – whether we should be concerned about the lack of nutrients in table sugar, honey, and maple syrup 

54:55 – stevia as a potential endocrine disruptor that may have negative effects on the thyroid, liver, and kidneys 

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-110-the-true-cause-of-insulin-resistance-and-diabetes-from-the-bioenergetic-view/

Timestamps:

0:00 – intro

1:14 – metabolic flexibility, earning your carbs, the carb-insulin model of obesity, and dispelling other common insulin resistance myths

7:48 – low-carb, keto, and carnivore diets may improve symptoms but are not the solution for insulin resistance

13:13 – what the mainstream views of insulin resistance gets wrong when it comes to what causes insulin resistance

15:50 – why you might not want to use a continuous glucose monitor and the unnecessary fear of blood glucose spikes

17:48 – whether insulin is harmful and whether we want to keep insulin levels as low as possible

22:15 – whether we can restore optimal insulin sensitivity without low-carb diets 

25:16 –the bioenergetic view of insulin resistance 

27:12 – insulin resistance as an adaptive evolutionary process that is crucial for survival

31:22 – the difference between physiological and pathological insulin resistance

34:40 – how inhibited glucose oxidation causes insulin resistance

40:46 – how fatty acid oxidation causes increased production of ROS, slows cellular respiration, and blocks glucose oxidation (The Randle Cycle)

51:06 – the harms of ROS production from fatty acid oxidation and other forms of stress

53:04 – insulin resistance as an energy deficient state

54:19 – insulin resistance is not an insulin signaling problem, it’s an energy production problem 

58:30 – the role of stress hormones (like cortisol) in insulin resistance 

1:02:09 – how insulin and carbohydrates decrease stress 

1:05:59 – how to fix insulin resistance and restore insulin sensitivity by fixing our capacity to produce energy  

1:10:38 – specific diet, movement, and supplementation recommendations for insulin resistance and diabetes 

1:17:55 – why you don’t need to tailor your carb intake to your carb tolerance   

Sign up for the Free Energy Balance Food Guide: https://jayfeldmanwellness.com/guide 

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-109-chris-palmers-brain-energy-type-1-diabetes-and-low-fat-diets-for-weight-loss-qa

Timestamps:

0:00 – intro

1:19 – our take on Chris Palmer's “Brain Energy” theory of mental health disorders

5:04 – challenging the misconception of a separation between the brain and body

8:03 – why low-carb, ketogenic, and carnivore diets can produce temporary mental health benefits

10:36 – how impaired energy production underlies poor brain health and how to fix it without using low-carb diets

14:05 – how fat burning can temporarily relieve symptoms of poor glucose utilization (with a major cost)

18:29 – why fatty acid oxidation is our default metabolic state under stress and underlies all chronic disease

22:20 – whether ketogenic diets promote metabolic flexibility

24:53 – poor glucose metabolism as a driver of Alzheimer’s disease and other mental health conditions

28:13 – the adaptive benefit of burning fat during stress

31:31 – blood sugar management for Type 1 Diabetes and whether a low-carb diet is optimal

38:13 – whether lowering fat intake is necessary for burning and losing fat

42:09 – whether improving metabolic function alone is enough to reduce stored fat and when a decrease in dietary fat intake may be necessary

47:32 – the difference between subcutaneous fat and visceral fat and their potential implications

50:34 – how to fix our hunger signals to prevent excessive eating

54:33 – weighing the costs of extreme diets and the need for more innovative thinking around health

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-108-herman-pontzers-burn-ted-naimans-pe-diet-and-increasing-calorie-intake-to-raise-metabolism-qa/

Timestamps:

1:25 – Herman Pontzer’s Constrained Model of Energy Expenditure and the adverse effects of energy deficits

7:13 – problems with the additive model of energy expenditure and the physiological cost of excess exercise

10:40 – environmental factors that we can change to increase metabolism

16:42 – the unexpected costs of using excessive exercise to lose weight

19:16 – weight gain as an adaptive response to an energy deficit

22:46 – when eating too much can be a problem and how to identify your ideal calorie intake

32:18 – Ted Naiman’s protein to energy ratio diet and optimal protein intake

41:13 – the problems with using protein as an energy source

46:45 – how to increase caloric intake to raise metabolism and reverse hypothyroidism

50:47 – how to track your symptoms and progress to better guide your nutrient goals

56:55 – the best foods for increasing calorie intake and what to do if you have a low appetite

1:00:30 – the essential role of both macro and micronutrient density in promoting mitochondrial health

1:04:00 – why sugar cravings are not the same as sugar addiction

1:06:46 – easy ways to incorporate more macro and micro nutrient dense foods into your diet

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-107-omega-3s-decrease-lifespan-and-increase-disease

Timestamps:

0:00 – intro

1:30 – studies showing that omega-3 consumption decreases lifespan and increases disease processes in animals

13:55 – studies on animals showing the harmful effects of omega-3 consumption during pregnancy on offspring

17:37 – studies showing that omega-3 consumption contributes to disease processes, increases inflammation, causes oxidative stress, increases endotoxin, and interferes with mitochondrial respiration

29:23 – whether we should be concerned about saturated fats increasing endotoxin absorption

30:33 – how omega-3 consumption leaves us more susceptible to damage when we’re under stress

33:52 – whether we should be consuming fatty fish

37:00 – the lack of benefit of omega-3 consumption in native populations consuming large amounts of fatty fish and seafood

46:14 – low incidence of cardiovascular disease in native populations consuming very little omega-3s

1:05:18 – concluding thoughts on whether we should consume omega-3s based on the data on omega-3s in RBCs and phospholipids and mortality

Check out the Energy Balance Mini-Course here: https://www.jayfeldmanwellness.com/energy/

Check out the Energy Balance Food guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: https:/jayfeldmanwellness.com/ep-106-omega-3s-increase-inflammation-and-oxidative-stress/

Timestamps:

0:00 – intro

1:26 – a summary of the harmful effects of omega-3 consumption in humans

9:14 – omega-3 consumption amplifies the damage from stress (including fasting)

17:08 – vitamin E does not protect against lipid peroxidation from fish oil consumption

20:06 – studies showing that increased omega-3 consumption (including fish oil and cod liver oil) in humans and other animals increases lipid peroxidation, even in triglyceride form

31:45 - how omega-3s triggers hormesis, and why this doesn’t make omega-3s beneficial

39:50 – the context of the omega-3 research and its application

42:57 – studies showing that omega-3 supplementation doesn’t improve chronic health conditions or reduce mortality in humans

Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

Click here to check out the show notes: 

https://jayfeldmanwellness.com/ep-105-challenging-the-idea-that-increased-omega-3-consumption-lowers-mortality/

Timestamps:

0:00 – intro

1:35 – why we’re discussing omega-3s and lifespan

8:10 – the studies showing an association between omega-3 content in phospholipid and reduced mortality

16:48 – conflict of interest as a confounding variable in these studies

18:12 – healthy user bias as a confounding variable in these studies

20:46 – omega-6 consumption as a confounding variable in these studies

29:04 – problems with using RBC phospholipids and serum fatty acids as markers of fatty acid composition of the diet

30:35 – a low omega-6 diet will increase omega-3 content in the RBC phospholipids and serum fatty acids

36:35 – the effect of heritability on RBC phospholipid and serum fatty acid composition

43:58 – the effect of oxidative stress on RBC phospholipid and serum fatty acid composition

52:57 – why it’s important to consider interventional studies and other research to determine whether we should increase omega-3 consumption to reduce mortality

55:30 – research looking at the relationship between composition of phospholipids and lifespan across species

1:07:33 – research looking at the relationship between composition of phospholipids and lifespan within species

1:23:30 – increased consumption of omega-3s increases omega-3 content in phospholipids and therefore the peroxidizability index

1:28:53 – looking at the Masai diet: low omega-6 intake increases omega-3 content in RBC fatty acids

Check out the Energy Balance Solution program here: https://www.jayfeldmanwellness.com/solution/

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Click here to check out the show notes: 

https://jayfeldmanwellness.com/ep-104-how-western-culture-keeps-us-distracted-and-fighting-amongst-ourselves/

Timestamps:

1:14 – individualism and competition vs. collaboration and communitarianism

25:45 – randomness, subjectivism, moral relativism, and the resulting nihilism

31:20 – the consequences of the idea that humans are selfish, destructive, and useless other than what we can produce

41:39 – how potentially beneficial advancements become co-opted to maintain the current power structure

48:04 – how western culture degrades esteem and prevents self-actualization

49:43 – the many aspects of modern technology and entertainment that distract us from what’s important

55:26 – how drugs and alcohol can also function as numbing agents

1:03:42 – how worthy causes become co-opted to prevent legitimate progress

1:13:18 – contrasting with cultures that are family-oriented and less distracted by technology

1:16:10 – the effects of culture in science, health, and everyday life   

Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/

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Click here to check out the show notes: 

https://jayfeldmanwellness.com/ep-103-how-western-culture-keeps-us-poor-and-destroys-our-family-community-and-relationships/

Timestamps:

1:34 – how western culture degrades safety and security through financial means

7:33 – how lower wages with higher costs reduces safety and forces people to prioritize work over quality of life

15:14 – we currently work more with less leisure time than ever before, with worse outcomes

20:24 – the cost of consumer culture and marketing as an engine that drives consumerism

30:53 – the cost of convenience culture: freedom, privacy, morals, ethics, and health

36:14 – the problems with profit-driven motives and the collusion between government and corporations

45:36 – how western society has become fragile and unstable

51:13 – how western culture degrades relationships and feelings of love and belonging

52:41 – continued how western culture degrades relationships and feelings of love and belonging

53:27 – divide and conquer tactics within western culture and encouraging the “us vs. them” mentality   

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-102-how-western-culture-mainstream-medicine-keep-us-sick/

Timestamps:

0:00 – why we’re discussing culture and our concerns with the culture in the US and the relationship between culture and health  

6:05 – frames through which we can view culture and the importance of Maslow’s hierarchy of needs

13:00 – how western culture degrades health: diet culture and the food industry

27:43 – how western culture degrades health: excess work, time indoors, and sedentarism 

34:30 – how easily we can become numb to the effects of our culture or environment 

38:07 – the broken modern medical system and the problems with the allopathic, symptom management model 

48:21 – problems with the alternative health sphere  

Download the Free Energy Balance Food Guide here: https://www.jayfeldmanwellness.com/guide/

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-101-building-a-bioenergetic-diet-optimal-carb-fat-and-protein-sources/

Timestamps:

0:00 – intro 

1:34 - bioenergetic food guide 

2:59 - bioenergetic fat sources 

6:20 - bioenergetic protein sources 

15:01 - the importance of collagen/gelatin 

18:51 - bioenergetic carbohydrate sources 

31:25 – foods and additives to avoid 

34:15 – experimentation and context as primary components of the bioenergetic view 

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-100-building-a-bioenergetic-diet-macros-calories-and-meal-timing/

Timestamps:

0:00 – intro 

1:21 – context for these dietary guidelines and the importance of the “why” 

7:58 – guidelines for optimal protein intake from the bioenergetic view 

14:46 – guidelines for optimal fat intake from the bioenergetic view 

29:27 – guidelines for optimal carb intake from the bioenergetic view  

31:32 – how to find your starting calorie intake 

35:29 – guidelines for optimal carb intake from the bioenergetic view (continued) 

42:00 – using taste, cravings, hunger, and experimentation to adjust these guidelines 

45:35 – guidelines for optimal meal and snack timing and composition from the bioenergetic view 

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-99-medications-supplements-for-hypothyroidism-and-the-problems-with-t4-medications-hypothyroidism-part-5/

Timestamps:

0:00 – intro 

1:24 – vitamin and mineral supplementation for thyroid function 

5:22 – the context for using thyroid hormone supplementation 

7:16 – the problems with using T4-only medications (like Synthroid and levothyroxine) for hypothyroidism 

13:58 – evidence that T4 monotherapy is less effective than T3/T4 combination therapy 

21:48 – how to use T3, T4, and/or desiccated thyroid (NDT) for hypothyroidism 

37:15 – whether thyroid hormones should be taken away from food due to absorption concerns 

41:49 – how much is 1 grain of desiccated thyroid? 

42:29 – whether thyroid hormone supplements are pharmaceuticals, food, or something in between 

44:30 – whether we should be concerned about thyroid hormone supplementation suppressing endogenous thyroid hormone production 

46:50 – thyroid hormone supplements in context 

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-98-how-to-optimize-your-diet-lifestyle-for-hypothyroidism-hypothyroidism-part-4

Timestamps:

0:00 – intro 

1:06 – how to address and reverse hypothyroidism

2:36 – the importance of carbs, calories, and fat for improving thyroid function

16:24 – the importance of eating consistently (and not fasting) for thyroid function

18:00 – saturated fats vs. PUFA and micronutrients for thyroid function

19:45 – basic bioenergetic diet recommendations for hypothyroidism

22:14 – anti-thyroid foods (goitrogens) to avoid

23:08 – other diet considerations when transitioning to a bioenergetic approach

25:56 – low iron in women and excess iron from carnivore or keto diets

27:47 – cruciferous vegetables and thyroid health

28:43 – how to properly address nutrient deficiencies for thyroid health

35:06 – whether stressors like exercise, cold thermogenesis, caloric restriction, and fasting are supportive of thyroid health

47:54 – optimizing sleep for thyroid function

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-97-how-to-properly-test-for-thyroid-function-hypothyroidism-part-3

Timestamps:

0:00 – intro 

1:17 – what causes Hashimoto’s hypothyroidism and autoimmunity in general

13:30 – how to interpret thyroid blood tests (TSH, T3, T4, rT3) 

31:34 – what reverse T3 means on a blood test and how to interpret rT3 values

34:44 – looking at all thyroid markers together to determine thyroid status 

37:05 – the anti-thyroid effects of reverse T3

40:38 – cholesterol levels as a marker of thyroid status, and the problems with cholesterol levels that are too high or too low

52:34 – the relationship between cholesterol, heart disease, and thyroid status

56:04 – other blood markers that can be indicative of thyroid status (SHBG, ferritin)

57:02 – how we can use symptoms like metabolic rate, body temperature, and pulse rate to determine thyroid status  

1:12:14 – other symptoms that can be used as indicators of thyroid status (low energy, fatigue, low immune function, dry or cracking skin, hair loss brittle nails, slow motility, weight gain, low mood)

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-96-avoid-low-carb-diets-fasting-and-caloric-restriction-if-you-have-hypothyroidism-hypothyroidism-part-2/

Timestamps:

0:00 – intro 

1:28 – the factors that affect thyroid hormone production, conversion, transport, and uptake

3:45 – the impact of stress on thyroid hormone production and conversion 

5:02 – how the stress hormones and inflammatory cytokines affect thyroid hormone production and conversion

16:44 – thyroid hormones increase sensitivity to stress hormones 

21:44 – elevated free fatty acids, especially PUFA, inhibit thyroid hormone binding

23:26 – how a lack of energy prevents the cells from taking up thyroid hormone

30:00 – how oxidative stress affects thyroid hormone production and the effects of TSH on oxidative stress

38:25 – how a low-carb diet affects thyroid hormone production and conversion, causing a hypothyroid state; high-carb diets vs. low-carb diets for thyroid health

47:46 – insulin resistance is associated with reduced thyroid hormone conversion, but this doesn’t mean you should avoid carbohydrates  

51:39 – how caloric restriction affects thyroid status

55:04 – the effects of fasting on thyroid status

56:42 – T3 has positive feedback on its own production and what this means for thyroid hormone replacement

1:00:01 – the effects of PUFA and endotoxin on thyroid hormone activity

1:04:30 – the effects of micronutrients, specifically iron, vitamin A, selenium, and iodine, on thyroid hormone production, conversion, and activity

1:16:30 – increased thyroid activity increases macronutrient and micronutrient needs, but also improves micronutrient retention in the long-term

1:19:15 – the effects of environmental toxins (pesticides, industrial chemicals, heavy metals, etc.) on thyroid hormone production, conversion, and activity

1:25:20 – the effect of sleep on thyroid hormone production and conversion 

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-95-hypothyroidism-in-context-thyroid-hormone-basics-hypothyroidism-part-1/ 

Timestamps:

0:00 – intro 

1:19 – an introduction to hypothyroidism and common symptoms of hypothyroidism

9:02 – the broader biological context of hypothyroidism and hypothyroidism as a low metabolic state 

12:45 – why hypothyroidism is not the root cause

16:23 – the basics of the different thyroid hormones and their regulation

19:54 – the hypothalamic-pituitary-thyroid axis and the nuances within the negative feedback loops

24:45 – the basics of thyroid hormone production

29:37 – the basics of thyroid hormone conversion

35:17 – the larger context of thyroid hormone production and conversion

38:58 – the basics of thyroid hormone transport  

41:44 – the basics of thyroid hormone uptake

46:23 – the nutrients involved in thyroid hormone production and conversion

50:26 – the cellular effects of T3 (metabolic stimulation, uncoupling, autophagy, mitochondrial biogenesis, steroidogenesis from cholesterol)

57:29 – the effects of T3 on gut health, immune function, and aging

1:03:08 – whether low thyroid activity is beneficial for longevity and aging and when a high TSH may be a good sign

1:08:41 – the relationship between vitamin A and thyroid hormones 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-94-how-stress-crashes-your-metabolism-why-hormesis-is-not-the-answer-stress-mitochondria-part-2/

Timestamps:

0:00 – intro 

2:59 – the details of how mitochondrial respiration can become disrupted, especially from glucocorticoids

6:05 – the short-term effects of catecholamines

8:34 – why uncoupling is harmful in certain contexts and how PUFA cause constant, low-level uncoupling

14:40 – the protective effects of uncoupling as a part of the stress response

20:08 – the role of cytokines (TNF-alpha, IL-1, IL-6, heat-shock proteins, NF-kB, HIF) in the stress response

37:33 – the effect of acute stress on energy production in mitochondria

45:18– the effect of chronic stress on energy production in mitochondria

48:15 – how stress drives degeneration and the evidence for increased activity of hormetic pathways (including effects like mitochondrial biogenesis and autophagy) in degenerative states

1:05:24 – the relationship between mental health, mood, and metabolic function

1:10:21 – how adaptations to stress get passed on through mitochondrial DNA

1:18:32 – how to best improve mitochondrial function and our health

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-93-how-cortisol-affects-your-mitochondria-acute-vs-chronic-stress-stress-mitochondria-part-1-ep-93/ 

Timestamps:

3:00 – an introduction to the paper: mitochondria as key components of the stress response   

4:03 – Hans Selye’s general adaptation syndrome and the process of stress in relation to energy balance  

23:30 – the 3 main effects of the stress hormones in the acute stress response and the cost to this response 

31:48 – long-term glucocorticoid exposure causes insulin resistance and the protective effects of high blood sugar in certain contexts 

34:04 – how long-term stress causes degeneration 

34:55 – functions of the mitochondria 

38:54 – mitochondria upregulate energy production in response to stress 

41:06 – the short-term vs. long-term effects of the glucocorticoids (cortisol)

44:03 – how stress causes hormetic adaptations and how the hormetic pathways cause degeneration over time

50:30 – how mitochondria respond to excess stress and how this relates to fat gain

59:04 – how chronic stress and exposure to cortisol causes impaired energy production, degeneration, immunosuppression & autoimmunity, mineral imbalance, swelling, allergies & hypersensitivity, and cancer metabolism

Ray Peat's Website: http://raypeat.com/

Ray Peat Interviews, Articles, Related Websites, and Other Resources: https://www.selftestable.com/ray-peat-stuff/sites

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-91-cod-liver-oil-dangers-the-croissant-diet-and-insulin-resistant-fat-cells-q-a/ 

Timestamps:

2:54 – what we think about cod liver oil as a vitamin A source  

9:50 – why someone may benefit from cod liver oil, and why it likely isn’t a result of the retinol  

10:56 – the immunosuppressive effects of omega-3s 

14:25 – the major problems with omega-3s, including cod liver oil specifically 

25:33 – clarifying our thoughts on the Croissant Diet 

28:26 – burning saturated fat versus burning PUFA and whether PUFA create more ROS than saturated fats  

31:41 – what we think of the idea that consuming saturated fats will allow for fat loss by causing insulin resistance in the adipocytes (fat cells)  

42:50 – why increasing fat burning doesn’t inherently lead to increased fat loss 

47:11 – whether increasing satiety is the key to fat loss 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-90-eating-5000-calories-per-day-fish-oil-water-weight-vs-body-fat-paleo-ketogenic-diet-q-a/ 

Timestamps:

2:44 – why fish oil shows anti-inflammatory and cholesterol-lowering effects, and why this doesn’t mean they’re beneficial 

11:25 – eating carrots with a meal versus away from a meal 

17:27 – our thoughts on the benefits from a paleo-ketogenic diet 

28:45 – which coral calcium supplement we recommend 

32:33 – dental issues from sugar consumption 

39:45 – what we think of orange juice with added calcium 

41:36 – how to determine whether weight gain is due to water weight or body fat  

51:57 – our experiences eating 5,000-6,000 calories per day 

1:03:23 – whether it’s helpful to use calorie calculators and context to consider when it comes to calorie calculators 

1:11:20 – how our current diets vary in contrast to when we were eating 5,000-6,000 calories per day

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Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-89-the-anti-inflammatory-effects-of-fruit-juice-and-the-hormonal-effects-of-pufa-vs-sfa/ 

Timestamps:

4:10 – the effects of different dietary fat compositions on phospholipid and neutral lipid compositions in the testicles  

18:31 – the effects of different dietary fat composition on oxidative damage and antioxidant status in the testicles

29:44 – the effects of different dietary fat composition on hormone production and metabolism in the testicles 

38:26 – introducing the next study discussing the effects of orange juice on a high-fat, high-carbohydrate meal in terms of inflammation and endotoxin  

44:14 – the effects of orange juice on blood glucose and insulin sensitivity 

47:55 – the effects of orange juice on ROS production, TLR2 and TLR4 expression, and plasma endotoxin 

51:35 – factors that could account for the benefits of orange juice 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-88-whether-soy-is-estrogenic-and-causes-infertility/ 

Timestamps:

3:06 – overview of the study we’ll be discussing 

5:57 – compounds in soy have potentially estrogenic thymic, immune, and hormonal effects 

10:20 – compounds in soy oppose testosterone and reduce its production 

13:33 – whether animal research translates to humans 

16:40 – BPA has anti-fertility effects in males that are parallel to supplemental estrogen 

27:39 – corn oil causes weight gain despite the same number of calories consumed

32:11 – the reproductive effects of soy, BPA, and estradiol 

44:50 – the amount of soy required to cause these reproductive effects 

Check out the Energy Balance Solution group coaching program: https://jayfeldmanwellness.com/solution

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-87-robb-wolf-on-ray-peat-and-the-bioenergetic-view-energy-obesity-evolution-and-paul-saladino/ 

Timestamps:

4:22 – how low-carb diets increase stress hormones and increase susceptibility to stress

22:32 – why being overweight or obese is not a sign of excess energy

34:20 – whether the bioenergetic view ignores evolutionary biology

49:30 – what we think of Paul Saladino’s interpretation of the “Ray Peat Diet”

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-86-robb-wolf-on-ray-peat-and-the-bioenergetic-view-stress-blood-sugar/ 

Timestamps:

4:30 – why we wanted to discuss Robb Wolf’s perspective of the bioenergetic view

8:25 – Robb’s main points against the bioenergetic view

9:52 – whether fat-burning and being keto-adapted is stressful and how blood sugar is regulated in these states

31:29 – the problems with elevated levels of glucagon, which occurs when someone is on a low-carb diet

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-85-fructose-and-uric-acid-are-david-perlmutter-and-rick-johnson-wrong-part-2/ 

Timestamps:

3:42 – whether our lack of uricase is reason for us not to consume fructose

33:23 – whether we should be avoiding fructose-containing foods like fruit due to their potential to increase uric acid production

46:25 – the role of endotoxin and gut health in uric acid production and gout

53:12 – ideal fructose sources and how to adjust fructose intake if someone is dealing with insulin resistance, non-alcoholic fatty liver disease, or gout

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-84-fructose-and-uric-acid-are-david-perlmutter-and-rick-johnson-wrong-part-1/ 

Timestamps:

3:56 – why we’re discussing fructose and uric acid

8:38 – the general argument that fructose consumption drives uric acid production and that this is responsible for disease and degeneration

14:48 – our general counterargument that fructose consumption does not drive disease and degeneration via uric acid production

18:41 – whether fructose depletes ATP in the liver 

30:03 – fructose is extremely protective and generally increases ATP availability in the liver 

36:27 – how fructose can increase uric acid via ATP depletion

38:51 – why fructose doesn’t cause ATP depletion and uric acid production unless it’s given in extreme, non-physiologically relevant contexts

1:04:50 – whether uric acid is the driver of metabolic syndrome and many degenerative conditions by driving oxidative stress 

1:15:46 – why xanthine oxidase is a major confounding variable to consider when evaluating whether uric acid production is harmful

1:27:02 – whether the activation of AMP deaminase is a reason not to consume fructose

1:27:55 – average fructose intakes are far below the amounts that are typically used in research

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-83-how-nutrient-partitioning-affects-eating-behavior-and-fat-loss/ 

Timestamps:

2:48 – overview of the study we’ll be discussing

6:21 – why excess energy and overeating don’t cause fat gain

13:59 – the flow of energy through our metabolic systems determines health

18:25 – insulin resistance is an adaptive process that allows for nutrient partitioning

22:31 – insulin resistance occurs in stress states, such as caloric restriction, fasting, and low-carb diets, to divert fuel to the most essential tissues 

29:24 – hunger and appetite are determined by the amount of energy available, not number of calories taken in

47:46 – physical inactivity results in the same harmful metabolic effects as starvation and excess exercise

56:31 – hyperpalatable sugar- and fat-containing foods do not cause obesity

1:00:26 – other factors that affect nutrient partitioning

1:09:46 – considerations to keep in mind when reading and evaluating research

1:13:35 – why an energetic deficit is not required for fat loss

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://www.jayfeldmanwellness.com/ep-82-maximizing-fitness-and-athletic-performance-from-the-bioenergetic-view-fitness-vs-health-part-3/ 

Timestamps:

2:44 – why exercise and physical fitness are generally beneficial as long as they’re kept in balance  

14:43 – the limits to our metabolic capacity and how this relates to exercise

29:47 – nutritional strategies to mitigate the harmful stress effects from high levels of exercise while maximizing performance

39:32 – addressing sleep and stress to mitigate the harmful stress effects from high levels of exercise while maximizing performance

45:18 – supplements to mitigate the harmful stress effects from high levels of exercise while maximizing performance

1:06:46 – concluding thoughts related to maximizing fitness and athletic performance from the bioenergetic view 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-81-whether-intense-exercise-and-endurance-training-should-be-avoided-fitness-vs-health-part-2/ 

Timestamps:

2:55 – the benefits of movement and exercise 

6:41 – whether intense exercise involving lactate production and heavy breathing/breathlessness is harmful 

10:13 – whether endurance training involving fat oxidation is harmful 

18:31 – drawing a line between fitness and health 

25:06 – how to determine how much exercise is right for you

38:23 – whether intense exercise and being highly active is always more harmful than helpful

43:33 – why “eat less and exercise more” doesn’t work and ignores major aspects of our physiology 

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-80-how-much-exercise-is-too-much-from-the-bioenergetic-view-fitness-vs-health-part-1/ 

Timestamps:

2:37 – framing the question of where health and fitness meet from the bioenergetic view

13:12 – how excess exercise can cause degeneration and contribute to various health conditions  

21:03 – what level of exercise is harmful for cardiovascular health 

29:55 – how the expensive tissue hypothesis applies to exercise 

45:14 – how excess exercise can steal energy from other areas of our physiology, and how this affects the calorie equation 

1:08:23 - can moderate-intensity endurance training for 25 minutes 3 days per week be too much?

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-79-hyperthyroidism-collagen-alternatives-and-forcing-mitochondrial-respiration-q-a/ 

Timestamps:

2:39 – is it beneficial to “force” increased mitochondrial respiration and the oxidation of glucose

15:09 – alternatives to collagen or gelatin protein powder 

19:19 – which food additives are worth avoiding 

58:53 – whether hyperthyroidism is something we should be concerned about

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-78-why-maximizing-energy-production-and-minimizing-stress-is-optimal-for-health-hormesis-part-4/ 

Timestamps:

3:22 – the difference between producing ROS in a high energy state compared to a low energy state  

9:38 – how ATP protects against oxidative stress

21:55 – how CO2 protects against oxidative stress

26:31 – how tighter mitochondrial coupling is better for inducing uncoupling

27:48 – the broader context of why we want to adapt to a high-energy, low-stress state 

33:28 – how exercise can be beneficial despite the stress it causes, rather than because of it

47:06 – how low-carb/ketogenic diets can be beneficial despite the stress they cause, rather than because of it

57:40 – what to expect when moving away from a hormetic approach 

1:02:16 – how the fact that we can’t avoid stress fits into the bioenergetic, anti-hormetic view 

1:03:39 – what anti-hormesis looks like in a practical sense

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-77-why-you-dont-want-to-force-autophagy-mitochondrial-biogenesis-uncoupling-hormesis-part-3/ 

Timestamps:

3:27 – why reductions in adaptive responses in degenerative states and the benefits of “hormetic” interventions does not lend support to hormesis

13:49 – why improving tolerance to stress is not inherently beneficial and the cost of stress across generations

28:58 – how the fact that stress is cumulative throws a wrench in the idea of hormesis  

37:05 –the difference between producing ROS in a high energy state versus a low energy state

49:16 – the low energy, high ROS state is a feature of degenerative conditions

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-76-why-caloric-restriction-is-not-responsible-for-lifespan-extension-hormesis-part-2/ 

Timestamps:

3:36 – the physiology of hormesis and the general support for hormesis

12:54 – outlining the problems with hormesis

18:51 – how differences between organisms confound the caloric restriction research 

37:34 – the problem with using proxy markers to evaluate health effects and the importance of context

48:20 – how differences between organisms confound the caloric restriction research (cont.)

51:58 – how hydration status and macronutrient ratios confound the caloric restriction research

55:57 – how the myopic hormetic view leads to the ignorance of many confounding variables

1:02:00 – how the restriction of particular amino acids, ad libitum feeding, and a refined diet confound the caloric restriction research

1:11:58 – how PUFA confounds the caloric restriction research

1:30:09  – how endotoxin and gut health confound the caloric restriction research

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-75-hormesis-as-an-anti-scientific-defense-for-industrial-pollution-and-chemical-exposure-hormesis-part-1/ 

Timestamps:

3:36 – an introduction to hormesis as a means to reverse aging and reverse chronic health conditions 

6:45 – what is hormesis

12:34 – the suspicious history of hormesis  

16:20 – the definitional problems with hormesis

34:51 – how hormesis is influencing dangerous public health policies

47:35 – the difference between stressor effects and specific effects, creating a distinction between stress and adaptation, and the problems with the terms “eustress” and “distress”

Sign up for the Free Energy Balance Mini-Course here: https://jayfeldmanwellness.com/energy

Click here to check out the show notes: https://jayfeldmanwellness.com/ep-74-refuting-nutrition-with-judys-thoughts-on-the-ray-peat-diet-part-2/ 

Timestamps:

3:03 – why low-carb diets drive physiological stress and carbohydrates oppose stress

21:51 – why carbohydrates are essential and why our endocrine systems are so tightly tuned to carbohydrate intake

29:19 – do most people have hypothyroidism?

44:38 – is hypothyroidism ever the root problem?

53:28 – how carnivore diets can cause hypothyroidism

1:01:36 – whether taking exogenous steroid hormones (like pregnenolone or progesterone) will increase cortisol

1:12:19 – should we focus on gut health over thyroid health?

1:23:31 – why are people really moving from carnivore to a “Ray Peat Diet?”